Adenosine Deaminase in the Diagnosis of Tuberculous Pleural Effusions

Bañales, José L.; Pineda, Pedro; FitzGerald, J. Mark; Rubio, Herrera; Selman, Moisés; Salazar-Lezama, Miguel Ángel

doi:10.1378/chest.99.2.355

Cited by 110 publications

(31 citation statements)

References 15 publications

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“…The ADA activity lags in disorders of cell mediated immunity as in AIDS. ADA measurements form a part of tools to diagnose tuberculosis in tubercular pleural, pericardial and peritoneal effusions and a sensitivity and specificity rates of 95-97% and 85-90%, respectively have been reported in literature [10][11][12][13][14]. In our study we have deduced a sensitivity and specificity of 92.85% and 96%…”

Section: Observations and Resultssupporting

confidence: 61%

A Prospective Study to comparatively assess the role of adenosine deaminase levels in contents of cold and pyogenic abscesses

Rampal¹,

Prajapati²,

Sharma³

2016

IJIMS

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Section: Observations and Resultssupporting

confidence: 61%

A Prospective Study to comparatively assess the role of adenosine deaminase levels in contents of cold and pyogenic abscesses

Rampal¹,

Prajapati²,

Sharma³

2016

IJIMS

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“…Total ADA was determined by the Blake-Berman method [9], which had the same diagnostic properties as the Giusti-Galanti method in a meta-analysis of 2,251 cases [10]. ADA 1 , one of the two isoenzymes that account for the pleural activity of ADA, was determined by the Carilaos-Gakis method.…”

Section: Methodsmentioning

confidence: 99%

Diagnostic value of adenosine deaminase in nontuberculous lymphocytic pleural effusions

Castro¹,

Nuevo²,

Pérez-Rodríguez³

et al. 2003

Eur Respir J

128

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Adenosine deaminase (ADA) can aid in the diagnosis of tuberculous pleural effusions, but false-positive findings from lymphocytic effusions have been reported. The purpose of this study is to assess the ADA levels in nontuberculous lymphocytic pleural effusions (lymphocyte count w50%) of different aetiologies.Altogether, 410 nontuberculous lymphocytic pleural fluid samples were consecutively selected. These included malignant effusions (n=221), idiopathic effusions (n=76), parapneumonic effusions (n=35), postcoronary artery bypass graft surgery effusions (n=6), miscellaneous exudative effusions (n=21) and transudative effusions (n=51).The ADA level reached the diagnostic cut-off for tuberculosis (40 U?L -1 ) in seven of the 410 cases (1.71%). The negative predictive value of ADA for the diagnosis of pleural tuberculosis was 99% (403 of 407 cases) in the group of lymphocytic pleural effusions. In five of these seven patients ADA 1 and ADA 2 were measured, and in all these cases (100%) ADA 1 /ADA p correctly classified these lymphocytic effusions as nontuberculous (ratio v0.42).This prospective study provides additional evidence that adenosine deaminase levels in nontuberculous lymphocytic pleural effusions seldom exceed the cut-off set for tuberculous effusions. The pleural fluid adenosine deaminase levels were significantly higher in different types of exudative effusions than in transudates. An adenosine deaminase level v40 IU?L -1 virtually excluded a diagnosis of tuberculosis in lymphocytic pleural effusions. Adenosine deaminase 1 /adenosine deaminase p correctly classified all nontuberculous lymphocytic pleural effusions with high adenosine deaminase levels. Eur Respir J 2003; 21: 220-224.

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“…In recent years, clinical interest in ADA has been focused on the enzyme assay in pleural fluids (22)(23)(24)(25)(26)(27)(28)(29)39). Piras et al (30), were the first to suggest that the measm'ement of ADA activity in pleural fluids could be useful in the assessment of tuberculous patients who are presented with pleural effusions where a significant increase in enzyme activity occurs.…”

Section: Introductionmentioning

confidence: 99%

Adenosine deaminase activity in serum and pleural effusions of tuberculous and non‐tuberculous patients

Al-Shammary

1997

IUBMB Life

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SUMMARYIn a retrospective study Adenosine deaminase (ADA), was assayed in 86 serum samples and 12 pleural fluid samples of patients with pulmonary tuberculosis. Serum and pleural fluid ADA levels were also examined in a group of 38 non-tuberculous patients with pleural effusion. Highly significant increases in both serum and pleural fluid ADA levels were noted in tuberculous patients when compared to both control enzyme cut-off values and non-tuberculous p]eural effusion patients. Negative Ziehl-Nielsen staining for acid fast bacilli and Purified Protein Derivative skin test results were obtained in 32.3% and 11.1% of the examined patients respectively. All these patients showed significantly elevated serum or pleural fluid ADA levels. It is hereby suggested that serum and pleural fluid ADA levels can in conjanction with other tests, serve as a marker in patients of pulmonary tuberculosis.

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Adenosine Deaminase in the Diagnosis of Tuberculous Pleural Effusions

Cited by 110 publications

References 15 publications

A Prospective Study to comparatively assess the role of adenosine deaminase levels in contents of cold and pyogenic abscesses

A Prospective Study to comparatively assess the role of adenosine deaminase levels in contents of cold and pyogenic abscesses

Diagnostic value of adenosine deaminase in nontuberculous lymphocytic pleural effusions

Adenosine deaminase activity in serum and pleural effusions of tuberculous and non‐tuberculous patients

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