Adenosine stimulates respiration in man.

In this pilot study some cardiac effects of exogenous adenosine on the denervated heart were studied in a patient with transplanted heart since 3 years. He was instrumented with catheters into the left coronary artery, the coronary sinus and the right ventricle. Adenosine was given in increasing doses intracoronarily, into the aorta at the diaphragmal level and into a peripheral vein.When given into the aorta pain was provoked dose-dependently and not different from a reference group. When given intracoronarily no pain was provoked except at the highest dose when a slight discomfort of the chest was provoked. After intravenous injection no pain was provoked in the chest or in adjacent structures.Coronary sinus flow increased dose-dependently and not different from the reference group. No increased heart rate response occurred after intravenous or intracoronary injections. Extensive degrees of sinus and AV nodal blockade occurred.In conclusion, the results are in keeping with a role for adenosine as a messenger between myocardial ischaemia and angina pectoris and cardiac sympathetic pressure response. The importance of innervation for proper sinus and AV nodal function was also illustrated. 137

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“…The patient experienced respiratory stimulation at dl dosages also in accordance with previous findings (1,12).…”

Section: Provocation Of Dainsupporting

confidence: 78%

Effects of Exogenous Adenosine in a Patient with Transplanted Heart. Evidence for Adenosine as a Messenger in Angina Pectoris

Lagerqvist

Sylvén

Helmius

et al. 1990

Upsala Journal of Medical Sciences

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“…Transient retrosternal chest pain was experienced by nine of the 10 patients, as previously described (Watt & Routledge, 1985;Sylven et al, 1986). This angina-like pain was shown in the present study to be associated with an increase in coronary flow.…”

Section: Discussionsupporting

confidence: 60%

Adenosine causes transient dilatation of coronary arteries in man.

Watt

Penny

Singh

et al. 1987

Brit J Clinical Pharma

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We investigated the effects of i.v. adenosine on coronary blood flow in 10 normal subjects undergoing investigation for chest pain. Coronary flow transiently doubled after > 3.5 mg adenosine without increase in perfusion pressure, systolic load or inotropic state at a constant, paced heart rate. The data provide direct evidence that adenosine dilates coronary arteries in man. The transience of the effect suggests a possible role for adenosine in repeated estimations of coronary flow reserve.

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“…In this group FEV1, PEFR and FVC (best of three readings; mean ± s.d.) demonstrated as a transient effect following intravenous boluses of adenosine (Watt & Routledge, 1985), and shows that respiratory stimulation is sustained during infusion of the nucleoside. Similar findings have recently been reported in abstract form by Biaggioni et al (1986).…”

Section: Resultsmentioning

confidence: 95%

“…Recently, dose depen-cant metabolism of adenosine would therefore dent stimulation of respiration in man in associa-be expected during the observed 15-20 s interval tion with biphasic heart rate changes produced between injection of adenosine and the onset of by intravenous boluses of adenosine has been respiratory stimulation. It is therefore unclear described (Watt & Routledge, 1985. whether the effects on respiration observed were Adenosine is rapidly metabolised, either by re-due to adenosine itself or a metabolite.…”

Section: Introductionmentioning

confidence: 99%

Intravenous infusion of adenosine but not inosine stimulates respiration in man.

Reid

Watt

Routledge

et al. 1987

Brit J Clinical Pharma

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1 The effects on respiration of intravenous infusions of the endogenous nucleoside adenosine and its deaminated metabolite, inosine, administered in random order, singleblind, were compared in six healthy volunteers.2 The infusion rate of each nucleoside was initially 3.1 mg min-' and was increased stepwise every 2 min, as tolerated, up to a possible maximum of 23.4 mg ml-'. The maximum dose rates received by all subjects were 8.5 mg min' for adenosine and 16.8 mg min-for inosine.3 Adenosine infusion at rates of 6.1 mg min-' and above caused a significant increase in minute ventilation, principally due to an increase in tidal volume, with an associated significant fall in end-tidal Pco2. Mean inspiratory flow rate increased and expiratory duration decreased during adenosine infusion, but there was no change in inspiratory duration. 4 Adenosine infusion also caused a significant increase in heart rate and a slight, but significant increase in systolic blood pressure.5 Infusion of inosine at dose rates up to 16.8 mg min-' produced no pharmacological effects. 6 This study shows that adenosine by infusion produces sustained respiratory stimulation in man and demonstrates that it does not depend on prior conversion of adenosine to inosine or related metabolites and that it is not secondary to systemic hypotension.

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Adenosine stimulates respiration in man.

Abstract: Respiratory effects produced by a series of intravenous boluses of adenosine were studied in nine healthy human subjects. Adenosine produced a significant dose-related increase in respiration, mostly due to increased depth of respiration. Possible mechanisms of this effect are discussed.

Cited by 94 publications

References 20 publications

Effects of Exogenous Adenosine in a Patient with Transplanted Heart. Evidence for Adenosine as a Messenger in Angina Pectoris

Effects of Exogenous Adenosine in a Patient with Transplanted Heart. Evidence for Adenosine as a Messenger in Angina Pectoris

Adenosine causes transient dilatation of coronary arteries in man.

Intravenous infusion of adenosine but not inosine stimulates respiration in man.

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