Adenotonsillar Hypertrophy and Epstein‐Barr Virus in Pediatric Organ Transplant Recipients

Shapiro, Nina L.; Strocker, Ali M.

doi:10.1097/00005537-200106000-00013

Cited by 26 publications

(42 citation statements)

References 20 publications

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“…The early symptoms can be non-specific, such as fever, malaise, and weight loss [16,48,58]. In children with primary EBV infection, infectious mononucleosis is the most-common presentation [16], often occurring in the early post-transplant weeks [59,60]. A histological diagnosis is required to differentiate infectious mononucleosis from a more-severe hyperplastic or neoplastic process [12].…”

Section: Clinical Featuresmentioning

confidence: 99%

The post-transplant lymphoproliferative disorder?a literature review

Shroff

Rees

2004

Pediatric Nephrology

145

118

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The Epstein-Barr virus (EBV)-induced post-transplant lymphoproliferative disorder (PTLD) affects 1%-10% of all paediatric renal transplant recipients. This is a heterogeneous group of conditions characterised by EBV-driven proliferation of B-lymphocytes in the face of impaired T-cell immune surveillance. The risk factors predisposing to PTLD are becoming better understood, but its pathogenesis and myriad of clinical and histological features remain poorly defined. While new treatment modalities are being tried with variable success, regular EBV surveillance and carefully monitored reduction of immunosuppression remain the mainstay of treatment. In this review, we have presented the current knowledge of this increasingly common complication in renal transplant recipients.

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Section: Clinical Featuresmentioning

confidence: 99%

The post-transplant lymphoproliferative disorder?a literature review

Shroff

Rees

2004

Pediatric Nephrology

145

118

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“…Another important disease that can occur after organ transplantation is posttransplant lymphoproliferative disorder (PTLD). Especially after renal transplantation, the incidence is reported to be 1.2-10% and mortality may be 10% despite treatment (15,17). Hyperplasia of the nasopharyngeal lymphoid tissue may be a PTLD precursor as in our case (15).…”

Section: Discussionmentioning

confidence: 60%

“…Especially after renal transplantation, the incidence is reported to be 1.2-10% and mortality may be 10% despite treatment (15,17). Hyperplasia of the nasopharyngeal lymphoid tissue may be a PTLD precursor as in our case (15). However, the growth of all lymphoid tissues located in Waldeyer's ring could be seen (17).…”

Section: Discussionmentioning

confidence: 61%

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The Importance and Place of Adenotonsillectomy in Syndromic Children

Aydın

Babakurban

2016

Turk Arch Otorhinolaryngol

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Objective: Upper airway obstruction and sleeping disorders are important issues in syndromic children, including mouth, lower-upper jaw, or all facial abnormalities. Tonsillectomy and/or adenoidectomy is required because of systemic problems and upper airway obstruction that increase the existing systemic problems, except those anomalies. However, tonsillectomy and/or adenoidectomy are mostly avoided because of the tendency to cause both intubation/ perioperative systemic problems and respiratory complications in the postoperative period and in delays in the oral intake. However, these surgeries are sometimes required. In this context, we present our experience related with performing tonsillectomy and/or adenoidectomy in syndromic children admitted to our hospital. Methods:We retrospectively examined the data on tonsillectomy and/or adenoidectomy performed in syndromic patients in our clinic between 2001 and 2011. Results:We did not observe any postoperative complications in adenoidectomy and/or tonsillectomy performed by the same surgeon in 14 syndromic cases. Conclusion:It should be noted that respiratory problems may arise from many different anatomical regions in syndromic patients. Therefore, surgery should be performed taking into consideration all of these factors in these patients. These patients must be hospitalized in the postoperative period. Keywords

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“…Adenotonsillar tissue from tonsillectomies performed on transplant recipients at our institution has shown EBV-related hyperplasia in up to 80% of cases [12,13]. Prior cross-sectional analysis of transplant recipients at Mattel-UCLA Children's Hospital has identified EBV seronegativity at the time of transplant as a risk factor for adenotonsillar enlargement [14,15]. One objective of this study was to develop a tool to identify adenotonsillar enlargement and therefore PTLD at an earlier stage.…”

Section: Discussionmentioning

confidence: 99%