Adenovirus infection: beware of plasma procalcitonin levels in children

Laveglia, Vanessa; Gorina, Núria; Cassanello, Pia

doi:10.1136/archdischild-2017-314307

Cited by 7 publications

(6 citation statements)

References 3 publications

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“…Unlike other documented respiratory viral infections had low WBC and CRP levels, human adenovirus infection typically results in high WBC and CRP levels [ 21 , 22 ], and the WBC and CRP levels had been compared between species B, C, and E in earlier studies [ 23 – 25 ]. In addition, the PCT value associated with changes in children with respiratory HAdV infection was observed in another study [ 26 ]. However, the associations between the WBC, CRP, and PCT values and adenovirus types have not been well understood; the differences in the WBC, CRP, and PCT levels to the various types and disease severity of respiratory HAdV infections have also not been fully explored.…”

Section: Discussionmentioning

confidence: 86%

Molecular Epidemiology and Clinical Features Analysis of Respiratory Adenovirus Infections Reveals Correlations between Genotype, Inflammatory Biomarkers, and Disease Severity

Dai

Huang

et al. 2020

BioMed Research International

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Background. Human adenoviruses (HAdVs) are commonly causing respiratory disease. We molecularly genotyped HAdV circulating in Chinese hospitalized children with respiratory infections and summarized the clinical profiles and common inflammatory biomarkers, so as to better determine their associations with disease severity. Method. Children with respiratory single HAdV infection cases that occurred from December 2017 to March 2019 were enrolled for a cross-sectional study. Clinical/laboratory features based on the genotypes of respiratory HAdV infection were reviewed for comparative analysis. Results. A total of 84 patients were enrolled, and HAdV types were identified from 82 patients. Species B (HAdV-7, 44%; HAdV-3, 43%, and HAdV-14, 5%) was the most common, followed by C (HAdV-2, 4% and HAdV-1, 1%) and E (HAdV-4, 1%). Severe HAdV infection and HAdV-7 infection groups were associated with significantly longer duration of fever and hospitalized days, higher morbidity of tachypnea/dyspnea, more pleural effusion, more respiratory rales, more frequently required mechanical ventilation, and significantly higher fatality rate. The elevated procalcitonin (PCT) and C-reactive protein (CRP) levels were significantly associated with severe HAdV infection. Conclusions. HAdV-7 and HAdV-3 were the most common types among children with respiratory adenovirus infection; vaccines against these two genotypes are in urgent need. PCT and CRP are significantly associated with the severity of HAdV infection.

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Section: Discussionmentioning

confidence: 86%

Molecular Epidemiology and Clinical Features Analysis of Respiratory Adenovirus Infections Reveals Correlations between Genotype, Inflammatory Biomarkers, and Disease Severity

Dai

Huang

et al. 2020

BioMed Research International

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“…The cut-off value of serum PCT used to rule out invasive bacterial infections in infants aged 7-91 days admitted for fever in a previous study is 0.3 ng/mL [ 5 ]. For adenovirus infections, the levels of serum PCT level range from 0.04-5.67 ng/mL (median 1.14 ng/mL) [ 7 ]. The level of serum PCT that distinguishes between invasive bacterial infections and adenovirus infections is vague; however, in our patient, PCT was markedly elevated; therefore, an invasive bacterial infection was more probable than adenovirus gastroenteritis or a urinary tract infection.…”

Section: Discussionmentioning

confidence: 99%

A Case of Late-Onset Group B Streptococcus Serotype Ⅰb Meningitis With Absence of Pleocytosis at the Initial Cerebrospinal Fluid Analysis

Chida¹,

Morıchı²,

Watanabe³

et al. 2022

Cureus

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Bacterial meningitis in infants is a life-threatening illness that survives significant neurological sequelae that remain in survivors. The current diagnostic gold standard for meningitis is bacterial isolation from culture or molecular diagnostics in the cerebrospinal fluid. The decision for antibiotics therapy before bacterial detection is made on microscopic and biochemical findings in the cerebrospinal fluid, however, some patient shows no microscopic finding and pleocytosis at the initial cerebrospinal fluid analysis. Herein, we report a case of late-onset group B Streptococcus serotype Ib meningitis that could be introduced with timelier antibiotic therapy even in the absence of pleocytosis without the detection of bacteria on smear at the initial CSF analysis.

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“…Por otro lado, en el estudio desarrollado por Kunze en 2016, el 42% de la población de estudio presentó niveles de PCT superiores a 0,5 ng/mL con una media de 0.75 ng/mL 5 . Laveglia et al 8 , reportaron un 70% de la población con niveles de PCT superiores a 0,5 ng/mL con una media de 1,14 ng/mL, valores que concuerdan con los resultados de este estudio donde la media de PCT fue 0,65±0,8 ng/mL.…”

Section: Discussionunclassified

Interpretación de biomarcadores en pacientes pediátricos con infección por Adenovirus

Huertas¹,

Noboa²

2020

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Objetivo: Evaluar el uso de los biomarcadores proteína C reactiva (PCR) y procalcitonina (PCT) para la valoración de severidad clínica en pacientes pediátricos diagnosticados con infección por adenovirus. Método: Se estudiaron 100 pacientes mayores de 28 días y menores a 15 años con diagnóstico confirmado de infección por adenovirus, en el Hospital Vozandes Quito, Hospital Metropolitano y Hospital de los Valles en el periodo enero 2010 a mayo 2019, se recolectó información demográfica y clínica de forma retrospectiva. las características clínicas y biomarcadores se compararon de acuerdo a la severidad de la patología respiratoria presentada, cuya clasificación por requerimientos terapéuticos la definió como leve, moderada y grave. Resultados: El 89% de los pacientes presentó severidad clínica leve, el 11% moderada y ninguno fue clasificado como severa. El 35% de los pacientes presentaron coinfección con al menos un virus adicional, estos presentaron severidad clínica moderada en el 63,3%. Los valores promedio de PCR fueron 61,3 ± 54,06 mg/L y PCT 0,65 ± 0,8ng/mL. Entre los pacientes con severidad clínica leve y moderada vemos que PCR y PCT fueron superiores en pacientes con severidad clínica leve 66,07±55,09 mg/L vs 22,71±19,60 mg/L, p=0,003 y 0,70±0,83 ng/mL vs 0,23±0,26 ng/mL, p=0.005 respectivamente. Al momento de predecir la severidad clínica de los pacientes pediátricos diagnosticados con adenovirus el área bajo la curva encontrada en estos dos parámetros fue 0,241 y 0,224 para PCT y PCR respectivamente, con valores de sensibilidad y especificidad bajo el 50%. Conclusión: Los biomarcadores PCT y PCR presentan limitada utilidad al momento de predecir la severidad clínica de los pacientes pediátricos diagnosticados con infección por adenovirus.

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Adenovirus infection: beware of plasma procalcitonin levels in children

Cited by 7 publications

References 3 publications

Molecular Epidemiology and Clinical Features Analysis of Respiratory Adenovirus Infections Reveals Correlations between Genotype, Inflammatory Biomarkers, and Disease Severity

Molecular Epidemiology and Clinical Features Analysis of Respiratory Adenovirus Infections Reveals Correlations between Genotype, Inflammatory Biomarkers, and Disease Severity

A Case of Late-Onset Group B Streptococcus Serotype Ⅰb Meningitis With Absence of Pleocytosis at the Initial Cerebrospinal Fluid Analysis

Interpretación de biomarcadores en pacientes pediátricos con infección por Adenovirus

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