Adequacy of a hospital-wide standard dose of 7mg/kg bodyweight gentamicin sufficient to achieve an adequate prophylactic maximum serum concentration (Cmax) in burn patients undergoing surgical burn wound treatment

Pharmacokinetics and Pharmacodynamics of Antimicrobial Agents in Burn Patients

“…Patient with severe burn injury often have an increased Vd and higher than expected doses may needed to achieve the goal peak, Usually, these agents are dosed in a weight-based fashion, using ideal body weight. Recent studies have shown that weight-based dosing of gentamicin and tobramycin, dosed at 7 mg/kg actual body weight and 10 mg/kg actual body weight respectively, can achieve peak concentrations greater than 20 mcg/mL [18,19].…”