Adequate lymphadenectomy for colorectal cancer: a comparative analysis between open and laparoscopic surgery

Batista, Vilson Leite; Iglesias, Antonio; Madureira, Fernando Athayde Veloso; Bergmann, Anke; Duarte, Rachel Perez; Fonseca, Bárbara Ferreira Saraiva da

doi:10.1590/s0102-67202015000200005

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…Adequate lymphadenectomy in colorectal cancer is essential to define the stage as well to plan the adjuvant therapy, especially for cases at stage III [8] . Furthermore, several studies have demonstrated that adequate lymph node retrieval might be associated with a reduced risk of death and an improved survival rate [3,9] . The results of our study show that in more than half of the patients (57.5%), the number of the evaluated lymph nodes was below the current standard number of 12, with a mean and median of 10.7 (± 5.6) and 10 in the examined lymph nodes, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Medication Related Osteonecrosis of the Jaw (MRONJ). Review and recent advances

Galiti

Karayianni

Tsiklakis

et al. 2022

Forum of Clinical Oncology

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Background The presence of lymph node metastasis is one of the most important prognostic factors for long-term survival of patients with colorectal cancer. Therefore, thorough pathologic examination of at least 12 lymph nodes is essential for accurate staging of this disease, as well as for choosing the best adjuvant treatment. The aim of this study is to assess the adequacy of lymph node harvest in patients with colorectal cancer. Methods This observational, cross-sectional study was performed on 584 patients with colorectal adenocarcinoma who had undergone surgery from 2012 to 2017. Thereafter, the relevant demographic, pathological, and surgical data were extracted from the patients' medical records; and a relationship between the number of evaluated lymph nodes and other variables was also assessed. Results Among 584 studies cases in this study, 336 (57.5%) subjects had fewer than 12 evaluated lymph nodes. Mean and median number of the evaluated lymph nodes were calculated as 10.7 (±5.6) and 10, respectively. The patients aged 60 years old and older and the cases with tumors located in descending colon and rectum were observed to have a higher likelihood of inadequate lymph node retrieval. After an average follow-up of a 60-month period, 63% of the patients were alive. For the patients in whom fewer than 12 lymph nodes had been assessed, the median survival was estimated to be 48 months. For the patients in whom the number of evaluated lymph nodes was ≥12, median survival was calculated to be 54 months. Conclusion The number of lymph nodes evaluated in our study was less than the standard number in more than half of the patients. Among various other factors, older age and tumor location in descending colon and rectum are found to be associated with suboptimal assessment of lymph nodes. The number of lymph nodes dissected is also associated with survival.

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Section: Discussionmentioning

confidence: 99%

“…Currently, adequate lymphadenectomy is defined as the presence of at least 12 lymph nodes in the surgical specimen. In this regard, previous studies have shown that a higher number of harvested lymph nodes is associated with increased survival rate [3] .…”

mentioning

confidence: 95%

Medication Related Osteonecrosis of the Jaw (MRONJ). Review and recent advances

Galiti

Karayianni

Tsiklakis

et al. 2022

Forum of Clinical Oncology

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show abstract

“…Adequate lymphadenectomy in colorectal cancer is essential to de ne the stage as well as planning the adjuvant therapy, especially for cases at stage III (8). Furthermore, several studies have demonstrated that adequate lymph node retrieval might be associated with the reduced risk of death and the improved survival rate (3,9).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Lymph Nodes Adequacy in Patients with Colorectal Cancer: Results from a Referral Center in Iran

Yahyazadeh

Mafi

Beheshti

et al. 2021

Preprint

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Background the presence of lymph node metastases is one of the most important prognostic factors for long-term survival of patients with colorectal cancer. So, thorough pathologic examination of at least 12 lymph nodes is essential for accurate staging this disease, as well as choosing the best adjuvant treatment. The aim of this study is to assess the adequacy of lymph node harvest in patients with colorectal cancer. Methods This observational cross-sectional study was performed on 584 patients with colorectal adenocarcinoma who had undergone surgery from 2012 to 2017. Thereafter, the relevant demographic, pathological, and surgical data were extracted from the patients’ medical records and a relationship between the number of evaluated lymph nodes and other variables was also assessed. Results Among 584 studies cases in this study, 336 (57.5%) subjects had less than 12 evaluated lymph nodes. Mean and median number of the evaluated lymph nodes were calculated as 10.7 (± 5.6) and 10, respectively. The patients aged 60 years old and older and the cases with tumors located in descending colon and rectum were observed to have higher chances of inadequate lymph node retrieval. After an average follow-up for a 60-month period, 63% of the patients were alive. In the patients for whom less than 12 lymph nodes had been assessed, the median survival was estimated as 48 months. As well, in the patients for whom the number of the evaluated lymph nodes was ≥ 12, median survival was calculated as 54 months. Conclusion The number of the evaluated lymph nodes in our study was less than the standard number in more than half of the patients. Among various factors, older age, and tumor location in descending colon and rectum are found to be associated with sub-optimal assessment of lymph nodes. The number of lymph nodes dissected is also associated with survival.

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“…A total of 16,660 new cases of colon and rectum cancer in men and 17,620 in women are estimated for 2016 in Brazil 2 . In locally advanced rectum cancer, survival after R0 resection is very good, and exenteration should be offered to patients with advanced primary or recurrent tumor, where resection is necessary in addition to total excision of the conventional mesorectum 6 .…”

Section: Introductionmentioning

confidence: 99%