ObjectiveThe aim of the present study was to analyse gender differences in
self-reported non-adherence (NA) to prescribed medication in the Swedish
general population. We aimed to study unintentional and intentional NA as
well as the reasons given for NA.MethodsA questionnaire was mailed to a cross-sectional, random, national sample of
people aged 18-84 years in Sweden (n=7985). The response rate was 61.1%
(n=4875). The questionnaire covered use of prescription drugs, NA behaviour
and reasons for NA.ResultsUse of prescription drugs was reported by 59.5% (n=2802) of the participants,
and 66.4% (n=1860) of these participants did not adhere to the prescribed
regimen. No overall gender differences in reporting NA were found. However,
when analysing the various types of NA behaviour and the reasons for NA,
different gender patterns emerged. Men were more likely to report forgetting
[OR=0.77 (95%CI 0.65:0.92)], changing the dosage [OR=0.64 (95%CI 0.52:0.79)]
and that they had recovered [14.3%, (OR=0.71 (95%CI 0.56:0.90)] as a reason.
In contrast, more women than men reported filling the prescription but not
taking the drug [OR=1.25 (95%CI 1.02:1.54)] and reported the development of
adverse drug reactions (ADRs) [OR=1.89 (95%CI 1.37:2.59)] as a reason more
commonly. The gender differences remained, in most cases, after controlling
for confounders such as age, socioeconomic factors, medical problems and
attitudes toward drugs.ConclusionsWomen and men have different patterns of NA behaviour and different reasons
for NA. Therefore, if adherence is to be improved, a wide knowledge of all
the reasons for NA is required, along with an understanding of the impact of
gender on the outcomes.