Adherence and proliferation of keratinocytes cultured with <i><scp>C</scp>andida albicans</i>

Ran, Yuping; Yamazaki, Masashi; Tsuboi, Ryoji; Ogawa, Hideoki

doi:10.1111/1346-8138.12497

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Immunity To Fungal Infections Of the Skin1

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2017

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“…At least one fungal defense against these peptides is the observation that secreted aspartic proteases (SAPS) released by Candida can cleave and inactivate LL-37 (130). Candida albicans binds keratinocytes (HaCaT cell line) at least in part through interaction between Gpm1(a fungal Factor H/FHL1-binding protein) and host vitronectin, and binding is associated with induction of proinflammatory cytokine production (131, 132). However, while keratinocytes express PRRs, in vivo evidence of their significance remains to be reported.…”

Section: Immunity To Fungal Infections Of the Skinmentioning

confidence: 99%

Immunity to Commensal Fungi: Detente and Disease

Wheeler

Limon

Underhill

2017

Annu. Rev. Pathol. Mech. Dis.

103

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Fungi are ubiquitous in our environment, and a healthy immune system is essential to maintain adequate protection from fungal infections. When this protection breaks down, superficial and invasive fungal infections cause diseases that range from irritating to life-threatening. Millions of people worldwide develop invasive infections during their lives, and mortality for these infections often exceeds 50%. Nevertheless, we are normally colonized with many of the same disease-causing fungi (e.g., on the skin or in the gut). Recent research is dramatically expanding our understanding of the mechanisms by which our immune systems interact with these organisms in health and disease. In this review, we discuss what is currently known about where and how the immune system interacts with common fungi.

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Section: Immunity To Fungal Infections Of the Skinmentioning

confidence: 99%