Adherence to antidepressant therapy and mortality rates in ischaemic heart disease: cohort study

Abstract

Adherence to antidepressant pharmacotherapy is associated with reduced all-cause mortality in a population-based large sample cohort of patients with IHD. Physicians and health policy decision-makers should step up their efforts to sustain and enhance these patients' adherence to their antidepressant regimen.

Adherence to antidepressant medications is associated with reduced premature mortality in patients with cancer: A nationwide cohort study

“…Similarly to our previous reports on mortality in other AD‐using populations (Krivoy et al, ; Krivoy et al, ; Krivoy et al, ; Shoval et al, ), our unadjusted analyses in the present study showed an increased rate of death in the higher adherence levels. As previously discussed broadly in these publications, we attribute this finding mainly to a more drug adherent behavior in the older and highly comorbid patients, therefore such findings demonstrate the importance of having the capability to adjust for important confounders.…”

“…This relationship is systematically repeated in all subtypes of cancer we studied, except for melanoma. Similarly to our previous studies in the general population and in certain other major physical disorders (Krivoy et al, ; Krivoy et al, ; Krivoy et al, ; Shoval et al, ), the beneficial effect of adherence to AD may be at least equally important in the high‐risk population of patients with cancer. Psychiatrists, Oncologists, and primary‐care physicians should step up their efforts to sustain and enhance their patients' adherence to AD, as it may be associated with increased life expectancy.…”

“…Adherence is reported as a percentage score for each patient. Similarly to previous literature (Krivoy et al, ; Krivoy et al, ; Krivoy et al, ; Shoval et al, ), patients with adherence below 20% were considered nonadherent, those with 20–50% adherence were considered poorly adherent, those with 50–80% were considered to have a moderate adherence and patients with adherence above 80% were considered to have good adherence. In accordance with previous research, we did not model adherence as a continuous variable, since our previous study demonstrated no superiority when considering adherence as a continuous versus the categorical variables described here (Krivoy et al, ).…”

The impact of age and gender on adherence to antidepressants: a 4-year population-based cohort study

“…Our measure of adherence was shown to be reliable (Krivoy et al 2015;Singer et al 2012). The large sample size (N =310,994) encompassed a nationwide sample of all patients who used AD along 4 years in the CHS database without an age limitation.…”

Management of Depression After Myocardial Infarction

“…Some evidence suggests increased medical risk: antidepressants combined with phenothiazines increase risk of sudden cardiac death shortly after myocardial infarction more than phenothiazines alone [67], and a long-term, non-randomized observational study found increased mortality over up to 42 months follow-up for patients taking serotonin reuptake inhibitors after myocardial infarction [68]. However, improved adherence (i.e., more exposure) to antidepressants was associated with reduced mortality in a 4-year follow-up study in ischemic heart disease patients with depression [69]. A 2011 metaanalysis [70] concluded that SSRIs improve depression but do not have a significant effect on readmission for CHD or all-cause mortality, although point-estimates of effect were in the direction of benefit.…”