The impact of age and gender on adherence to antidepressants: a 4-year population-based cohort study

Krivoy, Amir; Balicer, Ran D.; Feldman, Becca; Hoshen, Moshe; Zalsman, Gil; Weizman, Abraham; Shoval, Gal

doi:10.1007/s00213-015-3988-9

Cited by 40 publications

(30 citation statements)

References 27 publications

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“…Previous research has established positive relationships with age and female sex with increased adherence to prescription medications. With the rural group of participants being significantly older and having a larger proportion of females than suburban and urban participants, one would assume that the rural group would have increased adherence rates . This is, however, counterbalanced by the fact the rural participants reported lower income levels and an increased distance to the nearest pharmacy, which are associated with lower levels of medication adherence.…”

Section: Discussionmentioning

confidence: 99%

Evaluating Factors Impacting Medication Adherence Among Rural, Urban, and Suburban Populations

Arbuckle

Tomaszewski

Aronson

et al. 2018

The Journal of Rural Health

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Disclosures: Donald Morisky receives a royalty for use of the copyrighted and trademarked MMAS-8. Funding: Jon Schommer received The PetersInstitute in Pharmacy Practice Innovation, Endowed Chair Award, which was used to fund this project. Findings: Overall adherence rates did not differ significantly between rural and urban adults with average adherence based on MMAS-8 scores of 5.58 and 5.64, respectively (P = .253). Age, income, education, male sex, and white race/ethnicity were associated with higher adherence rates. While the overall adherence rates between urban and rural adults were not significantly different, the factors that influenced adherence varied between age-specific population density groupings. Conclusion:These analyses suggest that there is no significant difference in adherence between rural and urban populations; however, the factors contributing to medication adherence may vary based on age and population density. Future adherence intervention methods should be designed with consideration for these individualized factors.Key words access to care, health care access, medication adherence, medication use, pharmacy.Medication nonadherence is considered one of the greatest modifiable health risks to exist in the United States. Nearly half of all Americans who are prescribed a prescription medication are nonadherent to it. 1 The presence of nonadherence to prescription medications causes poor health-related outcomes. Nonadherence has been shown to increase the likelihood of disease progression, lead to higher utilization of health care services, increase the cost of care, and cause higher mortality rates. 2-9The cause of nonadherence is complex and there are many factors that have been linked to increasing rates of nonadherence. These include factors related to the cost of the medications, socioeconomic status, and convenience. [10][11][12][13][14][15] With increasing rates of poverty

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Section: Discussionmentioning

confidence: 99%

Evaluating Factors Impacting Medication Adherence Among Rural, Urban, and Suburban Populations

Arbuckle

Tomaszewski

Aronson

et al. 2018

The Journal of Rural Health

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“…Despite some difficulty in identification of such a set of factors, age is definitely a variable to be taken into account (Krueger et al, 2015;Krivoy et al, 2015). Additionally, it seems that factors which impact patient behaviour can vary depending on the age of an individual, although little research has been devoted to this issue (Barclay et al, 2007).…”

Section: Methodsmentioning

confidence: 99%

Factors Impacting On Patient Compliance with Medical Advice: Empirical Study

Krot

Sousa²

2017

Engineering Management in Production and Services

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The purpose of this paper to identify factors which have a bearing on compliance with medical advice in various age groups. The survey was conducted, using the CAWI method, on a representative sample of 1000 respondents who declared having used healthcare services in the previous six months. Control of competences is one of the strongest factors which is common for the oldest and youngest groups. Interestingly, trust in the integrity and honesty of doctors is significant for the youngest patients, i.e., the higher is the level of trust, the lower is the tendency to non-comply. Another type of trust is related to the benevolence of doctors and is significant to patients of the middle age group. Satisfaction is a significant predictor in the two oldest groups of patients. High levels of satisfaction seem to deter people from non-adherence to recommended treatment regimens. The results of the present study provide knowledge about the nature and diversity of factors behind patient compliance in various age groups.

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“…In this regard, it appears important to assess whether discontinuation to antidepressants can affect suicide risk. Further, it is crucial to explore suicide risk patterns according to the use of antidepressants in different genders and age groups, since important differences in antidepressant utilization have been observed in women compared to men, as well in older age groups compared to younger age groups …”

Section: Introductionmentioning

confidence: 99%

“…Further, it is crucial to explore suicide risk patterns according to the use of antidepressants in different genders and age groups, since important differences in antidepressant utilization have been observed in women compared to men, as well in older age groups compared to younger age groups. 9,12,[25][26][27] The aim of the present case-control study was to assess whether discontinuation to antidepressants is associated with an increased risk of suicide, according to different genders and age groups.…”

Section: Introductionmentioning

confidence: 99%

Discontinuation of antidepressants in suicides findings from the Friuli Venezia Giulia Region, Italy, 2005‐2014

Castelpietra

Bortolussi

Gobbato³

et al. 2018

Basic Clin Pharma Tox

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Although continued use of antidepressants (AD) has been found to be associated with a lower risk of suicide, AD discontinuation is reported repeatedly. The aim of this case‐control study, thus, was to assess whether discontinuation to AD was associated with an increased risk of suicide, according to different genders and age groups. The Social and Health Information System of Friuli Venezia Giulia Region, Italy, was used to collect data on suicides, diagnoses and AD use from 2005 to 2014. We selected, as cases, all suicides that had at least one prescription of AD in the 730 days before death (N = 876), and we matched with regard to age and sex each case with five controls from the general population. Conditional logistic regression analyses were used to assess the association between suicide and modifications of AD treatment. We found that 70% of suicides and controls from the general population discontinued AD in the 2 years before the index date. In two‐thirds of them, discontinuations were two or more. Discontinuation of AD, however, did not represent a significant risk factor for suicide. More appropriate care of depression, particularly by primary care physicians who widely prescribe AD, should be fostered in order to prevent suicide. However, more research is needed to assess to which extent AD discontinuation can affect suicidal risk.

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The impact of age and gender on adherence to antidepressants: a 4-year population-based cohort study

Cited by 40 publications

References 27 publications

Evaluating Factors Impacting Medication Adherence Among Rural, Urban, and Suburban Populations

Evaluating Factors Impacting Medication Adherence Among Rural, Urban, and Suburban Populations

Factors Impacting On Patient Compliance with Medical Advice: Empirical Study

Discontinuation of antidepressants in suicides findings from the Friuli Venezia Giulia Region, Italy, 2005‐2014

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