Adherence to oral bisphosphonates: 30 more minutes in dosing instructions matter

Vytrisalova, Magda; Touskova, Tereza; Ládová, Kateřina; Fuksa, Leos; Palička, Vladimír; Matoulková, Petra; Horák, Pavel; Stepan, Jan J.

doi:10.3109/13697137.2014.995164

Cited by 18 publications

(23 citation statements)

References 29 publications

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“…Previous research evaluating the translated versions of the BMQ had demonstrated similar values for internal consistency, with the Portuguese version and the Sinhalese version having a Cronbach’s alpha coefficient of 0.66 and 0.65, respectively [ 30 , 31 ]. Although the Cronbach’s alpha value for the Czech translation in our analysis was somewhat lower than in the other Czech study (0.85 for Necessity and 0.82 for Concerns), the high values indicate that both versions are suitable for measurement [ 17 ]. In the Polish version the alpha coefficient for Necessity was between 0.79 and 0.82, while for Concerns it was between 0.65 and 0.70, depending on the group participating in the study [ 20 ].…”

Section: Discussionmentioning

confidence: 89%

“…It is worth noting that validated translations already exist for the BMQ-Specific in both the Czech and Polish languages. The Czech version tested general drug use of patients with either diabetes, hypertension or rheumatic disease [ 16 ], and was later used to study the adherence to oral bisphosphonates [ 17 ]. In the Czech validation study, principal component analysis was performed to explore the structure of factors, and reliability was also investigated by Cronbach’s alpha [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…The Czech version tested general drug use of patients with either diabetes, hypertension or rheumatic disease [ 16 ], and was later used to study the adherence to oral bisphosphonates [ 17 ]. In the Czech validation study, principal component analysis was performed to explore the structure of factors, and reliability was also investigated by Cronbach’s alpha [ 17 ]. The Polish version was first used in an international research study to better understand the adherence to psychotropic medications during pregnancy [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Cross-Cultural Adaptation and Lingual Validation of the Beliefs about Medicines Questionnaire (BMQ)-Specific for Cholesterol Lowering Drugs in the Visegrad Countries

Boruzs

Dombrádi

Sándor

et al. 2020

IJERPH

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The goal of this study was to translate the Beliefs about Medicines Questionnaire – Specific (BMQ-Specific) for cholesterol-lowering drugs, into the Hungarian, Slovak, Czech and Polish languages and test their reliability with statistical methods. For this purpose, Cronbach’s alpha, confirmatory and exploratory factor analyses were conducted. The analyses included 235 Czech, 205 Hungarian, 200 Polish, and 200 Slovak respondents, all of whom were taking cholesterol-lowering drugs. The translations from English into the target languages were always done by two independent translators. As part of the validation process these translations were pilot tested and after the necessary alterations, they were translated back into English by a third translator. After the approval by the creator of the questionnaire, nationwide surveys were conducted in all four countries. The results of the confirmatory factor analysis were exceptionally good for the Czech and Slovak translations, while the Polish and Hungarian translations marginally crossed the predetermined thresholds. With the exception of a single Polish question, the results of the exploratory factor analysis were deemed acceptable. The translated versions of BMQ-Specific are reliable and valid tools to assess patients’ beliefs about medication, especially medication adherence among patients taking cholesterol-lowering medication. A comparison between the four countries with this questionnaire is now possible.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cross-Cultural Adaptation and Lingual Validation of the Beliefs about Medicines Questionnaire (BMQ)-Specific for Cholesterol Lowering Drugs in the Visegrad Countries

Boruzs

Dombrádi

Sándor

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…With specific reference to osteoporosis, simplification of dosing regimens of bisphosphonates (once-a-week and once-a-month) was found to have only a mild impact on medication adherence, whereas monitoring/supervision showed no impact on medication persistence [10]. However, the methods with a higher probability to improve adherence seem to be those which involve the patients in a higher understanding of risk [12,16,17].…”

Section: Introductionmentioning

confidence: 99%

How the knowledge of fracture risk might influence adherence to oral therapy of osteoporosis in Italy: the ADEOST study

et al. 2016

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“…Previous study in patients with HIV found that medication regimens with more complex administration instructions were associated with higher rates of non‐adherence . As shown in patients with osteoporosis, poor adherence to dosing instructions for bisphosphonates is common despite good compliance to the treatment . Non‐adherence to medication administration instructions can affect treatment outcomes and increase risks of drug‐related adverse effects.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic burden in interstitial lung disease: Lessons to learn

2019

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Background and objective Patients with interstitial lung disease (ILD) are often prescribed disease‐targeted and symptomatic therapies, both of which can cause significant treatment burden due to polypharmacy and drug–disease interactions. This study aimed to evaluate medication regimen complexity before and after introduction of ILD‐specific therapies. Potential drug–disease interactions were evaluated for patients who were prescribed prednisolone. Methods In this study, 214 patients with ILD were assessed for demographic information, co‐morbidities and medication use. Medication lists were reviewed prior to and after the introduction of ILD‐specific therapies. Complexity of treatment regimen was examined using the validated Medication Regimen Complexity Index (MRCI). Results Of the 214 patients, 75 had idiopathic pulmonary fibrosis (IPF) while the rest had inflammatory ILD (chronic hypersensitivity pneumonitis: 45; connective tissue disease‐related ILD: 41). Polypharmacy was common at baseline (IPF: 51%, inflammatory ILD: 63%). Following introduction of ILD‐specific therapies, median total MRCI scores significantly increased from 8 (interquartile range (IQR) = 8–15) to 22.5 (17.5–27.5) and 14.5 (8.5–21) to 21.5 (16–30) for IPF and inflammatory ILD groups, respectively (P < 0.0001 for both). Complex dosing instructions contributed the most to total MRCI scores for ILD‐specific therapies. Among patients receiving prednisolone (n = 113), 88% had ≥1 co‐morbidity which may be impacted. Common co‐morbidities included gastrointestinal diseases (56%), obesity (37%), osteoporosis (24%) and diabetes mellitus (18%). Conclusion Polypharmacy and complex medication regimen are common in patients with ILD of different aetiologies. There is a high frequency of potential drug–disease interactions among patients who are prescribed systemic corticosteroids. These findings highlight the need for careful evaluation of the impact of therapeutic complexity and burden in patients with ILD.

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Adherence to oral bisphosphonates: 30 more minutes in dosing instructions matter

Cited by 18 publications

References 29 publications

Cross-Cultural Adaptation and Lingual Validation of the Beliefs about Medicines Questionnaire (BMQ)-Specific for Cholesterol Lowering Drugs in the Visegrad Countries

Cross-Cultural Adaptation and Lingual Validation of the Beliefs about Medicines Questionnaire (BMQ)-Specific for Cholesterol Lowering Drugs in the Visegrad Countries

How the knowledge of fracture risk might influence adherence to oral therapy of osteoporosis in Italy: the ADEOST study

Therapeutic burden in interstitial lung disease: Lessons to learn

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