Adherence to Sleep Apnea Therapy and Use of Lipid-Lowering Drugs

Platt, Alec B.; Kuna, Samuel T.; Field, Samuel; Chen, Zhen; Gupta, Rajesh Kumar; Roche, Dominic; Christie, Jason D.; Asch, David A.

doi:10.1378/chest.09-0842

Cited by 82 publications

(50 citation statements)

References 46 publications

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“…30,31 Furthermore, adherence with pharmacological therapies does not consistently correlate with adherence with medical Author Manuscript devices such as CPAP. 21,32 In our study, the adherence to antihypertensive and lipidlowering medications was similar among patients who adhered to CPAP therapy and those who did not. In addition, health-related behavior such as alcohol consumption and smoking were similar among patients with OSA who were not treated with CPAP therapy because of ineligibility and among those who declined treatment.…”

mentioning

confidence: 49%

Association Between Treated and Untreated Obstructive Sleep Apnea and Risk of Hypertension

Marı́n¹,

Agustí²,

Villar³

et al. 2013

Survey of Anesthesiology

162

178

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Context-Systemic hypertension is prevalent among patients with obstructive sleep apnea (OSA). Short-term studies indicate that continuous positive airway pressure (CPAP) therapy reduces blood pressure in patients with hypertension and OSA.Objective-To determine whether CPAP therapy is associated with a lower risk of incident hypertension.Design, Setting, and Participants-A prospective cohort study of 1889 participants without hypertension who were referred to a sleep center in Zaragoza, Spain, for nocturnal polysomnography between January 1, 1994, and December 31, 2000. Incident hypertension was documented at annual follow-up visits up to January 1, 2011. Multivariable models adjusted for Corresponding Author: José M. Marin, MD, Respiratory Department, Hospital Universitario Miguel Servet, Avda Isabel la Católica, 1-3, 50006 Zaragoza, Spain (jmmarint@unizar.es).. Author Contribution: Dr Marin had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Conclusion-Compared with participants without OSA, the presence of OSA was associated with increased adjusted risk of incident hypertension; however, treatment with CPAP therapy was associated with a lower risk of hypertension. HHS Public AccessOBSTRUCTIVE SLEEP APNEA (OSA), a prevalent condition that is estimated to affect 17% of US adults, is associated with an increased risk for cardiovascular diseases and overall mortality. [1][2][3][4][5] Although treatment of OSA with continuous positive airway pressure (CPAP) therapy is associated with decreased overall cardiovascular risk, its efficacy in preventing new-onset hypertension is unknown. 2Several cross-sectional studies link OSA to arterial hypertension, a major risk factor for fatal and nonfatal cardiovascular events. [6][7][8][9][10] However, the association between OSA and increased rate of incident hypertension has not been observed consistently in prospective studies. 11,12 A relatively short follow-up period (<5 years) and a limited inclusion of patients with severe OSA hinder conclusions regarding the association of OSA with incident hypertension. 11,12 Further more, the contribution of change in body weight over time, a well-established risk factor for both hypertension and OSA, to the development of newonset hyper-tension has not been investigated in patients with OSA. 13 Treatment of OSA eliminates repetitive episodes of hypoxia associated with transient cessation of breathing and stabilizes cardiovascular function. 14 Short-term studies indicate that CPAP use is associated with a reduction in blood pressure in patients with hypertension and OSA. 15 Whether long-term CPAP therapy prevents or reduces the rate of new-onset hypertension in patients with OSA has not been investigated. We hypothesized that OSA is an independent risk factor for the development of new-onset hypertension and that longterm CPAP therapy reduces this risk regardless of change in body weight over time. Clinical DataDemographic, anthropomet...

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mentioning

confidence: 49%

Association Between Treated and Untreated Obstructive Sleep Apnea and Risk of Hypertension

Marı́n¹,

Agustí²,

Villar³

et al. 2013

Survey of Anesthesiology

162

178

View full text Add to dashboard Cite

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“…Even though the patients in the two OSA categories were similar in regard to the measured characteristics, several unmeasured characteristics may confound or moderate the results. For example, research suggests that patients who are adherent to their prescription medications are also more adherent to PAP therapy for OSA, 19 and thus may have better control on their comorbidities. We were also unable to account for the severity of OSA in patients who carried the diagnosis, nor were we able to quantify the adherence to the use of postoperative PAP therapy in either patient category.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Untreated Obstructive Sleep Apnea on Cardiopulmonary Complications in General and Vascular Surgery: A Cohort Study

Abdelsattar

Hendren

Wong

et al. 2014

Journal of the American College of Surgeons

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“…oxidative stress in patients with obstructive sleep apnea hypopnea syndrome using Chinese herbal medicines (16,17). In addition, surgery has been associated with potential complications, such as profuse bleeding, cardiopathy and hypertension, and uncertainty regarding its long-term therapeutic effect (18,19).…”

Section: Treatment and Prevention Of Inflammatory Responses Andmentioning

confidence: 99%

Treatment and prevention of inflammatory responses and oxidative stress in patients with obstructive sleep apnea hypopnea syndrome using Chinese herbal medicines

Chen

Lin

Hong

et al. 2016

Experimental and Therapeutic Medicine

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Adherence to Sleep Apnea Therapy and Use of Lipid-Lowering Drugs

Cited by 82 publications

References 46 publications

Association Between Treated and Untreated Obstructive Sleep Apnea and Risk of Hypertension

Association Between Treated and Untreated Obstructive Sleep Apnea and Risk of Hypertension

The Impact of Untreated Obstructive Sleep Apnea on Cardiopulmonary Complications in General and Vascular Surgery: A Cohort Study

Treatment and prevention of inflammatory responses and oxidative stress in patients with obstructive sleep apnea hypopnea syndrome using Chinese herbal medicines

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