Adherence with Drug Therapy in Pregnancy

Matsui, Doreen

doi:10.1155/2012/796590

Cited by 100 publications

(83 citation statements)

References 45 publications

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“…Second, it is unknown to which degree patients were adherent to the prescribed medication; a challenge that not least could be of relevance during pregnancy 26, 27, 28. In particular, for the drugs with low number of observations in our study, the results could be vulnerable to variations caused by variable adherence in single subjects.…”

Section: Discussionmentioning

confidence: 89%

Treatment With Antipsychotics in Pregnancy: Changes in Drug Disposition

Westin

Brekke

Molden

et al. 2017

Clin Pharma and Therapeutics

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Although pregnancy is known to cause changes in drug pharmacokinetics, little is known about its impact on serum levels of antipsychotics. In this study we retrospectively assessed 201 routine serum antipsychotic therapeutic drug monitoring concentration measurements obtained from a total of 110 pregnancies in 103 women, and 512 measurements from the same women before and after pregnancy. Serum concentrations in the third trimester were significantly lower than baseline for quetiapine (−76%; confidence interval (CI), −83%, −66%; P < 0.001) and aripiprazole (−52%; CI, −62%, −39%; P < 0.001), but not for olanzapine (−9%; CI, −28%, +14%; P = 0.40). For the remaining antipsychotics (perphenazine, haloperidol, ziprasidone, risperidone, and clozapine), our dataset was limited, but it indicates that concentrations may decline at least for perphenazine and possibly also for haloperidol. Even though the clinical consequence of the serum concentrations decline remains to be elucidated, our results warrant close clinical monitoring throughout pregnancy, preferentially supported by therapeutic drug monitoring.

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Section: Discussionmentioning

confidence: 89%

Treatment With Antipsychotics in Pregnancy: Changes in Drug Disposition

Westin

Brekke

Molden

et al. 2017

Clin Pharma and Therapeutics

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“…If women are using alternative treatments for anxiety that are either not effective or not as effective as conventional treatment, they could face these serious maternal and child health issues. Meanwhile, it is well acknowledged that reduced adherence to medication during pregnancy is common (Matsui, 2012), and the decision to take medication during pregnancy may be particularly complex in the case of psychotropic drugs owing to social pressure (Stepanuk, Fisher, Wittmann-Price, Posmontier, & Bhattacharya, 2013). Research suggests that pregnant women are concerned about the effects of medication on their unborn baby (Stepanuk et al, 2013) and may choose to try an alternative that they consider to be safer (Holst et al, 2009b).…”

Section: Prevalence Predictors and Characteristics Of Herbal Medicimentioning

confidence: 99%

Women's Use and Self-Prescription of Herbal Medicine during Pregnancy: An Examination of 1,835 Pregnant Women

Frawley

Adams

Steel

et al. 2015

Women's Health Issues

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“…Noncompliance to medications and treatment plans is not uncommon among pregnant women which might be gauged by concerns related to fetus health 11 . However, herbal or complementary medicine tends to be more accepted as they are perceived to be a safer option although they might be not 12 .…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Ginger for Pregnancy-Induced Nausea and Vomiting: A Systematic Review

AlHajri

AlFalasi

Abdelrahim

et al. 2017

Journal of Natural Remedies

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The development of Nausea and Vomiting in Pregnancy (NVP) is rife, affecting approximately 80% of pregnant females, where only 1% of these might progress to develop a severe form of NVP known as hyperemesis gravidarum [1][2][3] . NVP is commonly seen between the 5 th and the 18 th weeks of gestation, and affect the overall well-being of patients 4 . Importantly, the severity of the NVP varies among pregnants, and consequently, the management will vary as well. Although there are plenty of etiologies and pathophysiological theories underpinning NVP, it is still considered to be an area of controversy 5. The importance of addressing NVP lies behind the possibility of developing dehydration, affecting the pregnancy, affecting the quality of life, productivity, and might lead to depression 6 . Treatment modalities incorporate identifying trigger factors and avoiding them, utilizing pharmacological and complementary agents and supportive therapy 7-9 .Ginger (Zingiber officinale), which is a common ingredient in Asian meals, started gaining momentum as a treatment modality for NVP 10 . Noncompliance to medications and treatment plans is not uncommon among pregnant women which might be gauged by concerns related to fetus health 11 . However, herbal or complementary medicine tends to be more accepted as they are perceived to be a safer option although they might be not 12 . Hence, this systematic review aims at investigating the efficacy of ginger in relieving NVP. Although investigating the safety of this ingredient is imperative, the majority of studies included in this systematic review were conducted for a very short period (e.g. four days), and used different doses and dosage forms, therefore rendered this objective unachievable. AbstractNausea and Vomiting (N/V) are unpalatable manifestations seen commonly during pregnancy, which impinge upon the overall well-being, the productivity and might result in hospitalization. There is growing evidence concerning the efficacy of ginger in alleviating Nausea and Vomiting in Pregnancy (NVP). Therefore, we sought to conduct a systematic review to explore the effectiveness of ginger for NVP. A comprehensive search was conducted in Google Scholar, PubMed, and Science Direct which resulted in identifying five studies. These studies showed that ginger can improve NVP in a statistically significant manner (P< 0.05). Assessing the safety profile of this agent was difficult due to the short duration of intervention, and inconsistency in the dose and dosage form of ginger used. This study helped to glean evidence about the efficacy of ginger in NVP. It also emphasized the need for conducting more studies with a better quality and that are using standardized dose and dosage forms to be able to conduct a meta-analysis.

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Adherence with Drug Therapy in Pregnancy

Cited by 100 publications

References 45 publications

Treatment With Antipsychotics in Pregnancy: Changes in Drug Disposition

Treatment With Antipsychotics in Pregnancy: Changes in Drug Disposition

Women's Use and Self-Prescription of Herbal Medicine during Pregnancy: An Examination of 1,835 Pregnant Women

The Efficacy of Ginger for Pregnancy-Induced Nausea and Vomiting: A Systematic Review

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