Adherent-invasive Escherichia coli LF82 aggravated intestinal inflammation in colitis mice by affecting the gut microbiota and Th17/Treg cell differentiation balance

Sha, Sumei; Hong, Zhang; Gao, Huijun; Shi, Haitao; Quan, Xiaojing; Chen, Fenrong; Li, Meng; Xu, Bin; Liu, Xin

doi:10.1007/s00203-023-03570-4

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Effects Of Gut Microbiota and Their Metabolites On Postopera...1

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“…CD4 knockout alleviates the damage to gut motility caused by abdominal surgery in mice [ 77 ]. In a study, Escherichia coli affect the differentiation of Th17 and Treg cells to destroy the balance of Th17/Treg cells, then induce intestinal inflammation, and damage gut motility [ 78 ]. Amphiregulin derived fromTh17 cell promotes intestinal fibrosis by activating mTOR and MEK in intestinal myofibroblasts,which may lead to POI [ 79 ].…”

Section: Effects Of Gut Microbiota and Their Metabolites On Postopera...mentioning

confidence: 99%

Effect of the gut microbiota and their metabolites on postoperative intestinal motility and its underlying mechanisms

et al. 2023

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Gut microbiota is closely related to human health and disease because, together with their metabolites, gut microbiota maintain normal intestinal peristalsis. The use of antibiotics or opioid anesthetics, or both, during surgical procedures can lead to dysbiosis and affect intestinal motility; however, the underlying mechanisms are not fully known. This review aims to discuss the effect of gut microbiota and their metabolites on postoperative intestinal motility, focusing on regulating the enteric nervous system, 5-hydroxytryptamine neurotransmitter, and aryl hydrocarbon receptor.

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Section: Effects Of Gut Microbiota and Their Metabolites On Postopera...mentioning

confidence: 99%