Adhesion of fibronectin, vitronectin, laminin, and collagen type IV to intraocular lens materials in pseudophakic human autopsy eyes

Linnola, Reijo J.; Werner, Liliana; Pandey, Suresh K; Escobar-Gómez, Marcela; Znoiko, Sergey L.; Apple, David J.

doi:10.1016/s0886-3350(00)00748-3

Cited by 174 publications

(126 citation statements)

References 36 publications

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“…There is preliminary evidence that the Alcon AcrySof  IOL biomaterial provides such enhanced adhesion, or 'bioadhesion'. 90,91 This will require further study. (3) Barrier effect of the IOL optic: The IOL optic barrier effect plays an important role as a second line of defense against PCO, especially in cases where retained cortex and cells remain following ECCE ('no space, no cells').…”

Section: Three Iol-related Factors To Reduce Pcomentioning

confidence: 99%

Post cataract-intraocular lens (IOL) surgery opacification

Trivedi

Werner

Apple

et al. 2002

Eye

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Intraocular lens (IOL) implantation has no doubt been one of the most satisfying advances of medicine. Millions of individuals with visual disability or frank blindness from cataracts had and continue to have benefit from this procedure. It has been reported by ophthalmologists that the modern cataract-intraocular lens (IOL) surgery is safe and complication-free most of the time. This makes the watchword for any cataract surgeon to be 'implantation,' 'implantation,' 'implantation.' In the mid1980s, as IOLs were evolving rapidly, the watchword of the implant surgeon was 'fixation,' 'fixation,' 'fixation.' Most techniques, lenses and surgical adjuncts now allow us to achieve the basic requirement for successful IOL implantation, namely longterm stable IOL fixation in the capsular bag.However despite this advancement some items 'slipped through cracks.' In this article, we would like to alert the reader to a new watchword, namely 'opacification,' 'opacification,' 'opacification.' Here we will be talking about the good, the bad, and the ugly. Examples of the 'good' include the recent successes now being achieved in reducing the incidence of posterior capsule opacification. Examples of the 'bad' include various proliferations of anterior capsule cells, problems caused by silicone oil adherence to IOLs and problems with piggyback IOLs. The 'ugly' include the sometimes striking and often visually disabling opacifications occurring on and within IOL optics, both on some modern foldable IOLs as well as a poly(methyl methacrylate) (PMMA) optic degradation occurring with some models a decade or more after implantation.

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Section: Three Iol-related Factors To Reduce Pcomentioning

confidence: 99%

Post cataract-intraocular lens (IOL) surgery opacification

Trivedi

Werner

Apple

et al. 2002

Eye

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“…Literature reports suggest that this material is associated with a lower degree of PCO formation. 29,30 A few authors 31 found that in patients older than 60 years the rate of PCO formation was significantly lower in patients with DM and with an acrylic PC IOL than in patients without DM with a silicone foldable PC IOL. In contrast, within groups A and B, in eyes with partial anterior capsule overlap on the IOL optic there was a higher level of development of PCO, with a significant difference when compared with eyes with total anterior capsule overlap on the IOL optic.…”

Section: Discussionmentioning

confidence: 99%

A prospective evaluation of posterior capsule opacification in eyes with diabetes mellitus: a case–control study

Praveen

Vasavada

Shah

et al. 2014

Eye

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Aim To compare the development of posterior capsule opacification (PCO) between eyes with and without diabetes mellitus after single-piece hydrophobic acrylic intraocular lens implantation 4 years postoperatively. Methods In this prospective, observational case-control study carried out at Iladevi Cataract and IOL Research Centre, Ahmedabad, India, 75 consecutive eyes with diabetes mellitus (cases) were compared with 75 age-matched eyes with age-related cataract (controls). A detailed, preoperative and posterior segment evaluation was carried out in eyes with diabetes mellitus to detect the presence or absence of diabetic retinopathy (DR). The Mann-Whitney U-test was applied to compare the differences in the development of PCO between the two groups. Results There was no difference in median PCO between cases and controls at 1 month (2.0 vs 1.50, Po0.068), but cases had a higher median PCO at 12 months (2.95 vs 1.30, Po0.001). At 4 years, there was no significant difference in median PCO between cases and controls (3.75 vs 2.25, P ¼ 0.273). The duration of diabetes increased the incidence of PCO at 4 years (P ¼ 0.02). Severity of DR had no influence on the progress of PCO at 4 years (P ¼ 0.69). Conclusion Diabetes mellitus did not increase the incidence of PCO at 4 years. The duration of diabetes increased the risk of PCO. The severity of retinopathy did not influence the development of PCO.

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“…For instance, it has been reported that the optic material of the AcrySof IOL tends to readily absorb intensely adhesive proteins, including fibronectin and vitronectin, which may lead to a strong adhesion of the optic to the lens capsule, and to subsequent prevention of PCO. [27][28][29][30] Surface whitening, which is known to often occur around the AcrySof optic, 31 is supposed to consist of these proteins or water. On the other hand, the optic surface of the Sensar IOL seems to be smoother than that of the AcrySof IOL, because the Sensar IOL is made using cryo lathe cut and tumble polish methods, whereas the AcrySof IOL is made using cast moulding method.…”

Section: Discussionmentioning

confidence: 99%

Comparison of posterior capsule opacification between fellow eyes with two types of acrylic intraocular lens

Hayashi

Yoshida

Hayashi

2006

Eye

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Purpose To compare the degree of posterior capsule opacification (PCO) and visual function between fellow eyes that received two different types of hydrophobic acrylic intraocular lenses (IOLs). Methods Forty-five patients underwent bilateral phacoemulsification and implantation of an Alcon AcrySof IOL (MA60AC) in one eye and an AMO Sensar IOL (AR40e) in the fellow eye. The PCO density value was measured using the Scheimpflug videophotography system at 1, 6, 12, and 24 months after surgery. The incidence of eyes that required a neodymium:YAG (Nd:YAG) laser capsulotomy, visual acuity, and contrast sensitivity with and without a glare source were also examined. Results The mean PCO value did not show a significant increase in either the AcrySof MA60AC or Sensar AR40e IOL groups, and was similar between the two groups throughout the 24-month follow-up period. The incidence of Nd:YAG laser capsulotomy was also the same between the groups. No significant difference was found in mean visual acuity between the two IOL groups during the follow-up, and there was no significant difference in photopic or mesopic contrast visual acuity with and without a glare source at 1 and 24 months after surgery. Conclusion The degree of PCO in eyes with an AcrySof IOL are almost the same as that in eyes with a Sensar IOL, with the results that visual acuity and contrast sensitivity with and without glare are similar.

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Adhesion of fibronectin, vitronectin, laminin, and collagen type IV to intraocular lens materials in pseudophakic human autopsy eyes

Cited by 174 publications

References 36 publications

Post cataract-intraocular lens (IOL) surgery opacification

Post cataract-intraocular lens (IOL) surgery opacification

A prospective evaluation of posterior capsule opacification in eyes with diabetes mellitus: a case–control study

Comparison of posterior capsule opacification between fellow eyes with two types of acrylic intraocular lens

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