Adhesion ofLactobacilliand their anti-infectivity potential

Abstract

The probiotic potential of lactic acid bacteria primarily point toward colonizing ability of Lactobacilli as the most important attribute for endowing all the known beneficial effects in a host. Lactobacillus species exert health-promoting function in the gastrointestinal tract through various mechanisms such as pathogen exclusion, maintenance of microbial balance, immunomodulation, and other crucial functions. It has been seen that many surface layer proteins are involved in host adhesion, and play significant role in the modification of some signaling pathways within the host cells. Interaction between different bacterial cell surface proteins and host receptor has been imperative for a better understanding of the mechanism through which Lactobacilli exert their health-promoting functions.

Probiotics alter the immune response of gingival epithelial cells challenged by Porphyromonas gingivalis

“…Alternatively, probiotics could have induced a stressful environment by producing acids, bacteriocins or oxidative compounds, altering the transcription profile of the pathogen. This hypothesis is supported by data showing that the transcription of genes involved in biofilm formation, survival, and virulence of P. gingivalis is regulated by environmental changes …”

“…The decreased adhesion/invasion of P. gingivalis to GECs co‐infected with probiotics may indicate competition for the same receptor on the epithelial cell surface and/or decreased fitness of the pathogen. Adhesins of lactobacilli and bifidobacteria may compete with pathogens for receptors on the gut . Alternatively, probiotics could have induced a stressful environment by producing acids, bacteriocins or oxidative compounds, altering the transcription profile of the pathogen.…”

“…This suggests that P. gingivalis could induce changes that favor the adhesion of the probiotic strains to epithelial cells. These aspects are relevant, since the adhesive properties of probiotics may contribute to their beneficial effects . Adhesion of probiotics to host cells is mediated by extracellular polysaccharides and surface layer proteins .…”

“…These aspects are relevant, since the adhesive properties of probiotics may contribute to their beneficial effects . Adhesion of probiotics to host cells is mediated by extracellular polysaccharides and surface layer proteins . The expression of these surface components is regulated by environmental conditions, thus affecting their hydrophobic properties and adhesion efficiency .…”

Effect of intestinal flora on the formation of endometritis of sow

“…Therefore, these bene cial bacteria may involve in regulating bacteria balance, inhibiting conditional pathogens, and preventing colonization of pathogenic microorganisms. For instance, Lactobacillus are generally studied as probiotic agents, which affect pathogenicity of opportunistic pathogens and host immune regulation [10]. L. sakei releases spherical membrane vesicles (MVs) through its cell wall components by activating host TLR2 signals, thereby enhancing the production of IgA, and then preventing the incursion of pathogenic microorganisms and regulating the composition of intestines microbiota [11].…”