Adhesion of Tissue-Engineered Cartilage to Native Cartilage

Silverman, Ronald P.; Bonasser, Lawrence; Passaretti, David; Randolph, Mark A.; Yaremchuk, Michael J.

doi:10.1097/00006534-200004000-00019

Cited by 34 publications

(53 citation statements)

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“…135 However, when chondrocytes suspended in fibrin hydrogel were injected into the pores of the hydrogels, neocartilage tissue formed in the pores and integrated firmly with the cartilage discs. 135,245 Other studies in which the encapsulation of cells significantly enhanced integration between hydrogels and surrounding cartilage confirm that tissue engineering approaches can be useful mechanisms of integration. 48,80,103,210 Adhesion strength was also shown to increase when the surrounding tissue was treated with enzymes to remove glycosaminoglycans, which stimulated chondrocytes to proliferate.…”

Section: Integration With Surrounding Tissuementioning

confidence: 84%

Hydrogels for the Repair of Articular Cartilage Defects

Spiller

Maher

Lowman

2011

Tissue Engineering Part B: Reviews

404

312

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Section: Integration With Surrounding Tissuementioning

confidence: 84%

Hydrogels for the Repair of Articular Cartilage Defects

Spiller

Maher

Lowman

2011

Tissue Engineering Part B: Reviews

404

312

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“…5,6 In vitro and in vivo studies have shown that the addition of cell-free scaffolds functionalized with growth factors (GFs) may help induce chondrogenesis of endogenous progenitor cells, neotissue production by these cells, and subsequent integration of neotissue with host tissue (Fig. 1A).…”

Section: Introductionmentioning

confidence: 99%

Growth Factor-Mediated Migration of Bone Marrow Progenitor Cells for Accelerated Scaffold Recruitment

Liebesny

Byun

Hung

et al. 2016

Tissue Engineering Part A

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Tissue engineering approaches using growth factor-functionalized acellular scaffolds to support and guide repair driven by endogenous cells are thought to require a careful balance between cell recruitment and growth factor release kinetics. The objective of this study was to identify a growth factor combination that accelerates progenitor cell migration into self-assembling peptide hydrogels in the context of cartilage defect repair. A novel 3D gel-to-gel migration assay enabled quantification of the chemotactic impact of platelet-derived growth factor-BB (PDGF-BB), heparin-binding insulin-like growth factor-1 (HB-IGF-1), and transforming growth factorb1 (TGF-b1) on progenitor cells derived from subchondral bovine trabecular bone (bone-marrow progenitor cells, BM-PCs) encapsulated in the peptide hydrogel [KLDL] 3 . Only the combination of PDGF-BB and TGF-b1 stimulated significant migration of BM-PCs over a 4-day period, measured by confocal microscopy. Both PDGF-BB and TGF-b1 were slowly released from the gel, as measured using their 125

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“…Approaches to improve cell density at wound edges include use of cells in the interface region, enzymatic treatment, and use of immature constructs. Silverman et al 114 studied the adhesion between native cartilage discs, using fibrin glue polymer alone or mixed with fresh articular chondrocytes. Their results demonstrated that adhesion of cartilage-to-cartilage can be improved by an increased amount of chondrocytes in the interface region.…”

Section: Integrative Cartilage Repairmentioning

confidence: 99%

Articular cartilage repair and the evolving role of regenerative medicine

Bos¹

2010

OAS

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Among the growing applications of regenerative medicine, clinical articular cartilage repair has now been used for 2 decades and forms a successful example of translational medicine. Cartilage is characterized by a limited intrinsic repair capacity following injury. Articular cartilage defects cause symptoms, are not spontaneously repaired, and are generally believed to result in early osteoarthritis. Marrow stimulation techniques, osteochondral transplantation, and cell-based therapies, such as autologous chondrocyte implantation (ACI) and use of mesenchymal stem cells (MSCs), are used for tissue regeneration, symptom relief, and prevention of further joint degeneration. The exact incidence of cartilage defects and the natural outcome of joints with these lesions are unclear. Currently available cartilage repair techniques are designed for defect treatment in otherwise healthy joints and limbs, mostly in young adults. The natural history studies presented in this review estimated that the prevalence of cartilage lesions in this patient group ranges from 5% to 11%. The background and results from currently available randomized clinical trials of the three mostly used cartilage repair techniques are outlined in this review. Osteochondral transplantation, marrow stimulation, and ACI show improvement of symptoms with an advantage for cell-based techniques, but only a suggestion that risk for joint degeneration can be reduced. MSCs, characterized by their good proliferative capacity and the potential to differentiate into different mesenchymal lineages, form an attractive alternative cell source for cartilage regeneration. Moreover, MSCs provide a regenerative microenvironment by the secretion of bioactive factors. This trophic activity is believed to limit damage and stimulate intrinsic regenerative responses. Finally, important clinical issues are discussed, including techniques to study the role of implanted cells in tissue regeneration using cell labeling and cell tracking, the improvement of cartilage integration, the use of delayed gadolinium-enhanced magnetic resonance imaging of cartilage for early judgment of joint degeneration/regeneration, and the influence of regulatory rules for therapeutic application development.

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Adhesion of Tissue-Engineered Cartilage to Native Cartilage

Cited by 34 publications

References 0 publications

Hydrogels for the Repair of Articular Cartilage Defects

Hydrogels for the Repair of Articular Cartilage Defects

Growth Factor-Mediated Migration of Bone Marrow Progenitor Cells for Accelerated Scaffold Recruitment

Articular cartilage repair and the evolving role of regenerative medicine

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