Adhesion of White Blood Cells to Guinea-Worm Larvae

Reddy, C. R. R. M.; Parvathi, G.; Sivaramappa, M.

doi:10.4269/ajtmh.1969.18.379

Cited by 14 publications

(2 citation statements)

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“…This nematode, 468 Bissonnette, Beaudet endemic to South-east Asia, is not associated with systemic manifestations like the guinea-worm, which may induce arthritis. 5 The second factor which could explain the patient's articular manifestations is the fact that she is a carrier of the histocompatibility antigen HLA B27 and therefore is susceptible to a so-called reactive form of arthritis.10-12 In fact her oligoarticular inflammatory arthritis of the lower limbs and subsequent plantar fasciitis are suggestive of this. However, synovial infiltration with eosinophils has not been reported in B27-related arthropathy.…”

Section: Discussionmentioning

confidence: 99%

Reactive arthritis with eosinophilic synovial infiltration.

Bissonnette¹,

Beaudet²

1983

Annals of the Rheumatic Diseases

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SUMMARY A 17-year-old Cambodian-born female was recently evaluated for subacute seronegative arthritis involving both ankles and the right midfoot. Suboptimal response to a nonsteroidal anti-inflammatory drug prompted open synovial biopsy, which showed intensive eosinophilic infiltration of the synovial structures. Slight peripheral eosinophilia had been found before her admission to hospital, and Ankylostoma duodenale was isolated. Antiparasitic treatment offered little more relief. She was also found out to be a carrier of the histocompatibility antigen HLA B27, and it may be that despite unusual histological findings she had a B27-related reactive type of arthropathy. The relation to the parasitic infestation remains speculative.

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Section: Discussionmentioning

confidence: 99%

Reactive arthritis with eosinophilic synovial infiltration.

Bissonnette¹,

Beaudet²

1983

Annals of the Rheumatic Diseases

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“…Probably alkaloids acts as immunosuppressive and antinociceptive signal molecules [22]. White blood cells have been found to adhere to the Dracunculus cuticle especially in lesions of long duration [23]. Dracunculus usually elicits an antibody response, while, at the same time depressing IFN-γ production [24].…”

Section: N Pathogenicity and Host-pathogen Interactionmentioning

confidence: 99%

The current state of knowledge on dracunculiasis: a narrative review of a rare neglected disease

2023

Infez Med

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Dracunculiasis (Guinea Worm Disease) is a chronic disease that is primarily found in the arid and poor areas of our planet where water supply systems consist of open wells. This parasitic disease is transmitted to humans not only through the consumption of water contaminated with crustaceans harbouring larvae of Dracunculus medinensis, but also through the ingestion of paratenic (frogs) or transport hosts (fish). The natural progression of the disease is caused by adult worms invading connective tissues, leading to blistering and ulceration of the extremities, approximately one year after infection. In 1986, the Guinea Worm Eradication Program (GWEP) was launched and since then, the incidence of the disease has been reduced by over 99%. Indeed, the most recent global report from 2022 shows only 13 cases of human dracunculiasis worldwide, the lowest annual incidence ever reported. The new found knowledge of potential animal reservoirs and the recent discovery of possible edible paratenic hosts could pose challenges to the future eradication of this debilitating disease. Therefore, attempts to eradicate this parasitosis should not be postponed. Intensive research is needed in this neglected area of medicine, now that the goal is within reach.

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