Adhesive coatings based on melanin-like nanoparticles for surgical membranes

Scognamiglio, Francesca; Travan, Andrea; Turco, Gianluca; Borgogna, Massimiliano; Marsich, Eleonora; Pasqua, Mattia; Paoletti, Sergio; Donati, Ivan

doi:10.1016/j.colsurfb.2017.04.057

Cited by 25 publications

(22 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These suggest that a low glucose diet (e.g., ketogenic) for cancer therapies based on nanoparticles could be beneficial. Our results are in broad agreement with other reports on a variety of cancer cells [ 47 , 48 , 49 , 50 ].…”

Section: Resultssupporting

confidence: 94%

Light- and Melanin Nanoparticle-Induced Cytotoxicity in Metastatic Cancer Cells

et al. 2021

View full text Add to dashboard Cite

Melanin nanoparticles are known to be biologically benign to human cells for a wide range of concentrations in a high glucose culture nutrition. Here, we show cytotoxic behavior at high nanoparticle and low glucose concentrations, as well as at low nanoparticle concentration under exposure to (nonionizing) visible radiation. To study these effects in detail, we developed highly monodispersed melanin nanoparticles (both uncoated and glucose-coated). In order to study the effect of significant cellular uptake of these nanoparticles, we employed three cancer cell lines: VM-M3, A375 (derived from melanoma), and HeLa, all known to exhibit strong macrophagic character, i.e., strong nanoparticle uptake through phagocytic ingestion. Our main observations are: (i) metastatic VM-M3 cancer cells massively ingest melanin nanoparticles (mNPs); (ii) the observed ingestion is enhanced by coating mNPs with glucose; (iii) after a certain level of mNP ingestion, the metastatic cancer cells studied here are observed to die—glucose coating appears to slow that process; (iv) cells that accumulate mNPs are much more susceptible to killing by laser illumination than cells that do not accumulate mNPs; and (v) non-metastatic VM-NM1 cancer cells also studied in this work do not ingest the mNPs, and remain unaffected after receiving identical optical energy levels and doses. Results of this study could lead to the development of a therapy for control of metastatic stages of cancer.

show abstract

Section: Resultssupporting

confidence: 94%

Light- and Melanin Nanoparticle-Induced Cytotoxicity in Metastatic Cancer Cells

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In addition, MLNPs were incorporated into polysaccharide basedmembranes and their adhesion was studied in the external part of porcine intestine, a very moisty part of the lumen, in a Hank's Balanced Salt Solution (HBSS). The detachment of the membranes was evaluated, being observable that non-functionalized MLNPs membranes detached after 90 min, contrary to the MLNPs-incorporated ones, which were able to stay in place up to 24 h. The production of this kind of biomaterial is very important for the new generation of green nanosystems, with marked improved effects regarding biocompability and biosafety [61] .…”

Section: Bioengineering and Bioelectronicsmentioning

confidence: 99%

Melanin nanoparticles as a promising tool for biomedical applications – a review

et al. 2020

View full text Add to dashboard Cite

Melanin is a biopolymer of easy and cheap availability that can be found among the living organisms and excels for its biocompatibility and biodegradability properties, along with scavenging abilities, metal chelation and electronic conductance. This biomaterial can act as a nanocarrier or agent itself to be used in diverse biomedical applications, such as imaging, controlled drug release, bioengineering and bioelectronics, antioxidant applications and theranostics. In this review, the melanin source and structure, its physicochemical properties, melanin-like polymers as well as the differences among those will be elucidated. The focus will be the discussion of the current approaches that apply melanin nanoparticles (MNPs) and melanin-like nanoparticles (MLNPs) in the biomedical field, to which promising capabilities have been attributed, regarding optoelectronic, photoconductivity and photoacoustic. The use of these nanoparticles, in the last 10 years, in topics as drug delivery or theranostics will be detailed and the major achievements will be discussed. Overall, we anticipate that melanin can drive us toward a new paradigm in medical diagnostics and treatments, since applying melanin features possibly its use as a theranostics nanocarrier agent, not only for diagnostics, but also for photothermal therapy and controlled drug release through chemotherapy. Statement of significance We present here a timely and opportune review article focusing the significant potential of melanin nanoparticles in biomedical applications, which will be discussed thoroughly. This biomaterial presents multiple capabilities that may be taken into consideration towards cancer theranostics, expecting a high future impact in the nanosized-platforms design and performance.

show abstract

“…In this study, alginate/hyaluronan membrane was created via molding method 145 and coated by dopamine. 146 Han's research team fabricated tissue adhesive nanosheet using PDA. Catechol groups were oxidized and embedded within the sheets which contain free catechol functional groups, and acrylamide was allowed to interact with the sheets via free radical polymerization.…”

Section: Micro/nano Brous Lms Sheets and Patchesmentioning

confidence: 99%