Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology

Ishii, Makoto; Iadecola, Costantino

doi:10.1016/j.bbadis.2015.10.029

Cited by 47 publications

(45 citation statements)

References 124 publications

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“…In a recently published review, Ishii and Iadecola (2016) speculate that the association of increased plasma adiponectin levels with dementia found in some studies, may be surprising for the first moment, since low adiponectin levels are often associated with obesity-associated disorders and adiponectin is generally considered to have protective properties. However, these studies were conducted predominately in patients with AD, where weight loss is characteristic feature.…”

Section: Discussionmentioning

confidence: 99%

Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia

et al. 2017

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The aim of the study was to determine the role of adiponectin, leptin and resistin in various types of dementia and to investigate their association with inflammatory markers, insulin resistance and abdominal obesity. In 205 patients with dementia [89 with Alzheimer’s disease (AD), 47 with vascular dementia (VaD), 69 with mixed dementia (MD)], 113 persons with mild cognitive impairment and in 107 controls serum adiponectin, leptin and resistin levels, pro-inflammatory [interleukin-6 (IL-6), C-reactive protein (hsCRP) and chitotriosidase] and anti-inflammatory (25-OH vitamin D, HDL-cholesterol and paraoxonase 1) markers, as well as glucose metabolism parameters (glucose, insulin and HOMA-IR) were determined. In all-cause dementia adiponectin and resistin levels were significantly higher as compared to the controls; leptin levels did not show differences. Higher adiponectin levels concerned AD and MD, whereas higher resistin-VaD and MD. After stratification by abdominal obesity the differences in adiponectin levels remained significant in subjects without obesity. In all-cause dementia negative correlation of adiponectin with obesity, glucose metabolism parameters, IL-6 and hsCRP and positive correlation with HDL-cholesterol were found. Positive correlation of resistin with age, IL-6, hsCRP and chitotriosidase and negative correlation with HDL-cholesterol and paraoxonase 1 were stated. We conclude that dementia of neurodegenerative origin is characterized by elevated adiponectin levels, whereas dementia with vascular changes by increase of resistin. Association with inflammatory indicators may suggest the pro-inflammatory role of resistin in the development of dementia, especially in dementia of vascular mechanism. Identification of this novel biomarker may be important in preventing dementia.

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Section: Discussionmentioning

confidence: 99%

Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia

et al. 2017

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“…Of particular interest, both peripheral insulin resistance (the central pathophysiologic feature of type 2 diabetes) and “brain insulin resistance” (a much-discussed but poorly characterized entity) have been suggested to play important roles in neurocognitive dysfunction and dementia. Insulin resistance and the associated metabolic dysregulation can be driven by high-fat (“Western”) diet, physical inactivity, and obesity, and have deleterious effects on neurocognition ( Ishii & Iadecola, 2015a ).…”

Section: Introductionmentioning

confidence: 99%

Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction

et al. 2016

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Scientific evidence has established several links between metabolic and neurocognitive dysfunction, and epidemiologic evidence has revealed an increased risk of Alzheimer’s disease and vascular dementia in patients with diabetes. In July 2015, the National Institute of Diabetes, Digestive, and Kidney Diseases gathered experts from multiple clinical and scientific disciplines, in a workshop entitled “The Intersection of Metabolic and Neurocognitive Dysfunction”, to clarify the state-of-the-science on the mechanisms linking metabolic dysfunction, and insulin resistance and diabetes in particular, to neurocognitive impairment and dementia. This perspective is intended to serve as a summary of the opinions expressed at this meeting, which focused on identifying gaps and opportunities to advance research in this emerging area with important public health relevance.

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“…Despite the fact that adiponectin has protective effects for diabetes and atherosclerosis and anti-inflammatory properties, some authors suggest that patients with AD lose weight that may ultimately lead to lower leptin, higher adiponectin levels, and adiponectin resistance (9-11). Though adiponectin has receptors in neurological tissue and a role in insulin signaling, the relation among adiponectin and dementia is nevertheless in dispute (8,11). In three cross-sectional studies, authors failed to show significant differences regarding adiponectin levels between patients with AD and controls (9,12,13).…”

Section: Discussionmentioning

confidence: 99%

Determination of adiponectin, tumor necrosis factor-alpha, and adhesion molecules in Azheimer’s disease

Savaş¹

2019

Erciyes Med J

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Objective: Though the data regarding the mechanisms behind neurodegeneration in addition to amyloid plaques and neurofibrillary tangles are not clear, there are emerging data for inflammation and microvascular changes to have contribution to the pathology of Alzheimer's disease (AD). The relationships between numerous biomarkers also need to be investigated. This study aimed to assess inflammatory marker tumor necrosis factor-alpha (TNF-α), adiponectin (a modulator of anti-inflammation), and potential microvascular markers for AD including both intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in Turkish patients with AD and healthy elderly subjects, and the relationships among the variables in patients with AD. Materials and Methods: In this study, 46 patients with AD and 30 cognitively healthy controls over 60 years of age from the outpatient clinics of Ege University were included. Adiponectin, ICAM-1, VCAM-1, and TNF-α were evaluated by enzyme-linked immunosorbent assays. Results: The median adiponectin level in the AD group was higher than in the controls (p=0.002). Median VCAM-1, ICAM-1, and TNF-α values for patients with AD and the controls were similar. There were positive correlations between VCAM-1 and both TNF-α and adiponectin in the patients with AD (r=0.540, p<0.001, and r=0.301, p=0.044, respectively). Conclusion: Though a dramatic rise of adiponectin, and associations of VCAM-1 and both TNF-α and adiponectin in subjects with AD were shown, the clinical significances of these peripheral measurements need to be further investigated.

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Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology

Cited by 47 publications

References 124 publications

Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia

Association of adiponectin, leptin and resistin with inflammatory markers and obesity in dementia

Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction

Determination of adiponectin, tumor necrosis factor-alpha, and adhesion molecules in Azheimer’s disease

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