Adipocyte related peptides — galanin and resistin in endometrioid type endometrium cancer

Avcıoğlu, Sümeyra Nergiz; Yüksel, Hasan

doi:10.5603/gp.a2021.0229

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…Based on these results, we could hypothesize that the decreased resistin level in BBD may be a biochemical marker of metabolic alterations related to the development of BC and other neoplasms such as epithelial ovarian cancer, endometrial cancer, and esophageal squamous cell carcinoma [29][30][31].…”

Section: Discussionmentioning

confidence: 94%

Adipocytokines and Insulin Resistance: Their Role as Benign Breast Disease and Breast Cancer Risk Factors in a High-Prevalence Overweight-Obesity Group of Women over 40 Years Old

Sat-Muñoz

Martínez-Herrera

Quiroga-Morales

et al. 2022

IJERPH

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Insulin levels, adipocytokines, and inflammatory mediators trigger benign breast disease (BBD) and breast cancer (BC). The relationship between serum adipocytokines levels, overweight-obesity, metabolic disturbs, and BC is unclear. Methods: To analyze the serum levels of the adipocytokines, insulin, and the HOMA IR in women without breast disease, with BBD or BC, and the role of these as risk factors for benign breast disease or breast cancer. Results: Adipsin values > 0.91 and visfatin levels > 1.18 ng/mL represent a risk factor to develop BBD in NBD lean women (OR = 18; and OR = 12). Data in overweight-obese women groups confirm the observation due to insulin levels > 2.6 mU/mL and HOMA IR > 0.78, with OR = 60.2 and 18, respectively; adipsin OR = 26.4, visfatin OR = 12. Breast cancer risk showed a similar behavior: Adipsin risk, adjusted by insulin and visfatin OR = 56 or HOMA IR and visfatin OR = 22.7. Conclusion: Adipose tissue is crucial for premalignant and malignant tissue transformation in women with overweight-obesity. The adipocyte–breast epithelium interaction could trigger a malignant transformation in a continuum, starting with BBD as premalignant disease, especially in overweight-obese women.

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Section: Discussionmentioning

confidence: 94%

Adipocytokines and Insulin Resistance: Their Role as Benign Breast Disease and Breast Cancer Risk Factors in a High-Prevalence Overweight-Obesity Group of Women over 40 Years Old

Sat-Muñoz

Martínez-Herrera

Quiroga-Morales

et al. 2022

IJERPH

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“…The latest available studies show that elevated resistin levels correlate with endometrial cancer stimulation, development and invasion, which is associated with advanced cancer stage and a worse prognosis for the patient [ 41 , 173 , 178 , 187 , 188 ]. Nergiz Avcıoğlu et al [ 189 ] reported that resistin levels >0.27 ng/mL increased the risk of endometrial cancer by as much as 5.6 times. The pathomechanism of endometrial cancer development is associated with the activation of multiple signaling pathways, mainly the MAP kinase pathway, resulting in increased synthesis of P-selectin and fractalkine in endothelial cells [ 41 , 187 , 190 ].…”

Section: Resistinmentioning

confidence: 99%

The Role of Selected Adipocytokines in Ovarian Cancer and Endometrial Cancer

Stępień

Olczyk

Gola

et al. 2023

Cells

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Due to their multidirectional influence, adipocytokines are currently the subject of numerous intensive studies. Significant impact applies to many processes, both physiological and pathological. Moreover, the role of adipocytokines in carcinogenesis seems particularly interesting and not fully understood. For this reason, ongoing research focuses on the role of these compounds in the network of interactions in the tumor microenvironment. Particular attention should be drawn to cancers that remain challenging for modern gynecological oncology—ovarian and endometrial cancer. This paper presents the role of selected adipocytokines, including leptin, adiponectin, visfatin, resistin, apelin, chemerin, omentin and vaspin in cancer, with a particular focus on ovarian and endometrial cancer, and their potential clinical relevance.

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Adipocyte related peptides — galanin and resistin in endometrioid type endometrium cancer

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited. Articles in "Ginekologia Polska" are listed in PubMed.

Cited by 2 publications

References 30 publications

Adipocytokines and Insulin Resistance: Their Role as Benign Breast Disease and Breast Cancer Risk Factors in a High-Prevalence Overweight-Obesity Group of Women over 40 Years Old

Adipocytokines and Insulin Resistance: Their Role as Benign Breast Disease and Breast Cancer Risk Factors in a High-Prevalence Overweight-Obesity Group of Women over 40 Years Old

The Role of Selected Adipocytokines in Ovarian Cancer and Endometrial Cancer

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