Adipocytokines and Insulin Levels in Young Obese Subjects at Risk for Type II Diabetes – The STYrian Juvenile OBesity Study (STYJOBS)

Weihrauch, Gisela; Mangge, Harald; Pilz, Stephan; Almer, Gunter; Horejsi, Renate; Möller, W; Scharnagel, H; Stojaković, Tatjana; Dimitrova, R; Stroedter, L.; Borkenstein, Martin; März, Winfried

doi:10.1055/s-2005-871188

Cited by 1 publication

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“…observed in obese and nonobese children and adolescents that serum adiponectin was the strongest covariate to carotid IMT [18]. All the other published studies, mostly Japanese, show divergent results [19–23, 34, 35].…”

Section: Discussionmentioning

confidence: 99%

Are serum adiponectin concentrations in a population sample of 64‐year‐old Caucasian women with varying glucose tolerance associated with ultrasound‐assessed atherosclerosis?

Behre

Brohall

Hulthe

et al. 2006

Journal of Internal Medicine

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Abstract. Behre CJ, Brohall G, Hulthe J, Wikstrand J, Fagerberg B (Sahlgrenska University Hospital and Göteborg University, Göteborg; and AstraZeneca, Mölndal, Sweden). Are serum adiponectin concentrations in a population sample of 64-yearold Caucasian women with varying glucose tolerance associated with ultrasound-assessed atherosclerosis? J Intern Med 2006; 260: 238-244.Objective. To examine whether serum adiponectin concentrations were associated with subclinical atherosclerosis assessed as intima media thickness (IMT) in the carotid arteries in Caucasian women with varying degrees of glucose tolerance. Research design and methods. From a populationbased cohort of 64-year-old Swedish women, 533 subjects with type 2 diabetes (DM2, n ¼ 177), impaired glucose tolerance (IGT; n ¼ 178) or normal glucose tolerance (NGT, n ¼ 178) were recruited. Anthropometrics, usual cardiovascular risk factors were examined and ultrasound examination of the carotid arteries was performed. Results. Women with low adiponectin concentrations were characterized by thick IMT, higher prevalence of DM2, history of previous myocardial infarction, angina pectoris, antihypertensive treatment and high body mass index (BMI), waist circumference, plasma insulin, serum triglycerides, fasting glucose, HbA1c, and low serum HDL cholesterol levels. Carotid IMT correlated with HbA1c (r ¼ 0.24, P < 0.001), waist circumference (r ¼ 0.22, P < 0.001), plasma insulin (r ¼ 0.19, P < 0.001), BMI (r ¼ 0.18, P < 0.001), DM2 (r ¼ 0.16, P < 0.001), systolic blood pressure (r ¼ 0.16, P < 0.001), blood glucose (r ¼ 0.16, P < 0.001), triglycerides (r ¼ 0.15, P < 0.001), and reversely to adiponectin (r ¼ )0.11, P ¼ 0.01), HDL cholesterol (r ¼ )0.13, P ¼ 0.004), and alcohol intake (r ¼ )0.087, P < 0.05). A more detailed analysis of underlying associations was difficult due to a high co-linearity between these variable. Conclusions. Low serum adiponectin concentrations were associated with increased carotid artery IMT, and several risk factors for cardiovascular diseases, mainly those constituting the metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%