Adipocytokines in relation to cardiovascular disease

Voorde, Johan Van de; Pauwels, Bart; Boydens, Charlotte; Decaluwé, Kelly

doi:10.1016/j.metabol.2013.06.004

Cited by 192 publications

(143 citation statements)

References 104 publications

Supporting

Mentioning

135

Contrasting

Unclassified

Order By: Relevance

“…2). Adipose tissue produces both pro-inflammatory and anti-inflammatory adipokines 31) ; adiponectin and omentin-1 showed anti-inflammatory effects both in vitro and in vivo 32) . However, little is known about the clinical significance of adiponectin on the stability of coronary plaques in vivo.…”

Section: Discussionmentioning

confidence: 99%

Impact of Remnant Lipoprotein on Coronary Plaque Components

Matsuo

Matsuoka

Onishi

et al. 2015

JAT

View full text Add to dashboard Cite

Aim: Intravascular ultrasound (IVUS) is a useful modality for visualizing atherosclerotic lesions in coronary arteries, not only for the degree of arterial luminal stenosis but also for the plaque composition within the vessel walls. We aimed to determine the relationship between the clinical parameters and coronary plaque characteristics evaluated by IVUS in patients with stable angina under medical treatment. Methods: Plaque measurements within the coronary arteries were collected by coronary angiography and iMAP-IVUS in 40 men with stable angina. The serum remnant-like cholesterol (RemL-C) was measured using homogeneous assays and serum adiponectin and omentin-1 levels were measured by enzyme-linked immunosorbent assays.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of Remnant Lipoprotein on Coronary Plaque Components

Matsuo

Matsuoka

Onishi

et al. 2015

JAT

View full text Add to dashboard Cite

show abstract

“…A negative correlation has been identified between the concentration of omentin and the thickness of the intima-media complex in carotid arteries, their stiffness, BMI, waist circumference, systolic arterial pressure, fasting blood glucose level and the insulin resistance index HOMA-IR (homeostasis model assessment of insulin resistance). Consequently, omentin is closely linked to the metabolic syndrome and its deficiency plays a significant role in the development of atheromatosis in these patients [33][34][35]. Zhong et al have demonstrated lower plasma levels of omentin in patients with acute coronary syndrome (ACS) or stable angina pectoris than in the control group.…”

Section: Omentynamentioning

confidence: 99%

“…Stwierdzono negatywną korelację stężenia omentyny z grubością kompleksu intima-media tętnic szyjnych, ich sztywnością, BMI, obwodem talii, skurczowym ciśnieniem tętniczym, stężeniem glukozy na czczo oraz wskaź-nikiem insulinooporności HOMA-IR (homeostasis model assessment of insulin resistance). Dlatego też omentyna jest ściśle związana z ZM, a jej niedobór odgrywa znaczącą rolę w rozwoju miażdżycy u tych pacjentów [33][34][35]. Zhong i wsp.…”

Section: Omentynaunclassified

Role of omentin and vaspin in metabolic diseases in association with psoriasis

Kiluk¹,

Baran²,

Flisiak³

2017

View full text Add to dashboard Cite

Psoriasis is a chronic skin disease characterized by systemic inflammation associated with an increased risk of metabolic and cardiovascular complications. A special role in maintaining systemic inflammation is attributed to obesity. Adipose tissue is an active endocrine organ which, through adipokine secretion, is involved in the regulation of many systemic metabolic pathways. Obesity increases the risk of developing type 2 diabetes mellitus, atherosclerosis, cardiovascular diseases and hypertension. The paper presents the characteristics of two relatively recently discovered and little known adipokines: omentin and vaspin. They are considered to have beneficial effects preventing the development of metabolic disorders associated with obesity. In addition, attention was given to their possible involvement in the pathogenesis of psoriasis and potential use as markers of disease severity and the risk of developing metabolic complications. stReszczenIe Łuszczyca jest przewlekłą chorobą skóry, w której ogólnoustrojowy stan zapalny wiąże się ze zwiększonym ryzykiem rozwoju powikłań metabolicznych i sercowo-naczyniowych. Szczególne znaczenie w podtrzymaniu stanu zapalnego w organizmie ma otyłość. Tkanka tłuszczo-wa jest aktywnym organem endokrynnym, który poprzez wydzielane adipokiny bierze udział w regulacji licznych szlaków metabolicznych ustroju. Otyłość zwiększa ryzyko rozwoju cukrzycy typu 2, miażdżycy, chorób sercowo-naczyniowych oraz nadciśnienia. W pracy przedstawiono charakterystykę stosunkowo nowo odkrytych i mało poznanych adipokin: omentyny i waspiny, którym przypisuje się korzystne działanie, chroniące przed rozwojem zaburzeń metabolicznych towarzyszących otyłości. Ponadto zwrócono uwagę na ich potencjalny udział w patogenezie łuszczycy oraz możliwość wykorzystania jako markerów nasilenia choroby oraz ryzyka rozwoju powikłań metabolicznych.

show abstract

“…8 Leptin and adiponectin generally elicit opposing pro-inflammatory and anti-inflammatory effects. 9 It has been reported that adiponectin exerts vascular-protective effects by improving endothelial function and having antiinflammatory potency in the vascular wall. It was shown that adiponectin stimulates the production of NO in endothelial cells and improves NO bioavailability and endothelial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure

2016

View full text Add to dashboard Cite

Background: Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in patients with chronic kidney disease (CKD) including kidney transplant recipients (KTR). Secondary lipid metabolism disorders, endothelial dysfunction, and inflammation enhance the risk of CVD development in these patients. The aim of the present study was to investigate the lipid profile, adiponectin, leptin, nitric oxide (NO), and high sensitivity C-reactive protein (hs-CRP) levels in KTR and to compare these parameters with those of the patients with chronic renal failure (CRF), hemodialysis (HD) patients, and healthy controls. Methods: Serum adiponectin and leptin levels were measured by radioimmunoassay; hs-CRP was determined immunoturbidimetrically. Determination of NO was based on the Griess reaction. Results: Compared with the control group, serum NO and adiponectin levels were significantly higher in the KTR, CRF, and HD groups; hs-CRP levels were significantly higher in the KTR and HD groups; leptin levels were significantly higher in the KTR. In addition, serum NO level was significantly higher in the KTR compared to CRF cases. Adiponectin correlated positively with high density lipoprotein-cholesterol in the control and patient groups. A positive correlation was observed between hs-CRP and NO in the KTR and the patients with CRF. Serum adiponectin levels were inversely correlated with hs-CRP and leptin in the HD group. Conclusion: KTR suffer from inflammation and accompanying changes in levels of adipocytokines and NO which contribute to the increased risk of CVD in these patients.

show abstract

Adipocytokines in relation to cardiovascular disease

Cited by 192 publications

References 104 publications

Impact of Remnant Lipoprotein on Coronary Plaque Components

Impact of Remnant Lipoprotein on Coronary Plaque Components

Role of omentin and vaspin in metabolic diseases in association with psoriasis

Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure

Contact Info

Product

Resources

About