Adipokine actions on cartilage homeostasis

Dozio, Elena; Corsi, Massimiliano M.; Ruscica, Massimiliano; Passafaro, Luca; Steffani, Liliana; Banfi, Giuseppe; Magni, Paolo

doi:10.1016/b978-0-12-387042-1.00004-6

Cited by 15 publications

(13 citation statements)

References 69 publications

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“…Adipokines exert their actions in a wide variety of pathophysiological processes, including the complex mechanisms that regulate skeleton biology, both at bone and cartilage level [27]. In this study, neither leptin nor adiponectin influenced BMD, in contrast to previous studies that showed controversial effects of both adipokines on BMD, directly or indirectly, possibly via the production of proinflammatory cytokines in association with fat accumulation [2,4,5,13,25,28,29].…”

Section: Discussioncontrasting

confidence: 75%

“…In addition, there are several studies of visfatin in intertissular joint communication, denoting a local inflammatory effect of this particular adipokine in osteoarthritis, rheumatoid arthritis and/or other rheumatic diseases [27,34]. Visfatin might represent a model to study bone metabolism, even though the relationship between adipocytes and bone mass is a controversial issue at present [1-6, 24, 25, 28, 29, 31, 32].…”

Section: Discussionmentioning

confidence: 99%

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Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia

et al. 2015

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Bone mass acquisition may be compromised in survivors of childhood acute lymphocytic leukemia due to various factors, including adiposity. Fat accumulation can affect bone through the direct effect of adipokines or indirectly through the state of chronic inflammation. The aim of this study was to evaluate the effect of body composition and adipokines on bone mass in survivors of acute lymphocytic leukemia. This was a cross-sectional study of 56 survivors aged between 15 and 24 years, 44.6 % of whom received cranial radiotherapy (18-24 Gy), assessed according to body fat, lean mass, and bone mineral density (dual energy X-ray absorptiometry), computed tomography scan-derived abdominal adipose tissue, and adipokines by a multiple regression analysis. Both lumbar spine L-L (trabecular bone) and total body (cortical bone) bone mineral density were positively correlated with visfatin (p < 0.050). Lean mass index was positively correlated, while waist-to-height ratio was negatively correlated with cortical bone (p < 0.010). Low bone mineral density for chronological age was detected in 5.4 % of patients in total body, and 8.9 % at the lumbar spine. In survivors of acute lymphocytic leukemia, visfatin may play an important role in the complex relationship between body composition and bone. At present, visfatin may represent a model for further study of bone metabolism, and could possibly explain the unknown mechanisms linking bone metabolism and cancer.

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Section: Discussioncontrasting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia

et al. 2015

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“…Adipokines have a direct and important role on bone and cartilage metabolism [38], [39]. The co-dependence of bone and energy metabolism has never been studied in professional athletes.…”

Section: Discussionmentioning

confidence: 99%

Bone and Energy Metabolism Parameters in Professional Cyclists during the Giro d’Italia 3-Weeks Stage Race

et al. 2012

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Cycling is a not weight-bearing activity and is known to induce bone resorption. Stage races are really strenuous endurance performances affecting the energy homeostasis. The recently highlighted link, in the co-regulation of bone and energy metabolism, demonstrates a central role for the equilibrium between carboxylated and undercarboxylated forms of osteocalcin. Aim of this study was to understand the acute physiological responses to a cycling stage race in terms of bone turnover and energy metabolism and the possible co-regulative mechanisms underlying their relationship. We studied nine professional cyclists engaged in 2011 Giro d’Italia stage race. Pre-analytical and analytical phases tightly followed academic and anti-doping authority’s recommendations. Bone and energy metabolism markers (bone alkaline phosphatase, tartrate-resistant acid phosphatase 5b, total and undercarboxylated osteocalcin, leptin and adiponectin) and related hormones (cortisol and testosterone) were measured, by Sandwich Enzyme Immunoassays, at days -1 (pre-race), 12 and 22 during the race. The power output and the energy expenditure (mean and accumulated) were derived and correlated with the biochemical indexes. During the race, bone metabolism showed that an unbalance in behalf of resorption, which is enhanced, occurred along with a relative increase in the concentration of the undercarboxylated form of osteocalcin that was indirectly related to the enhanced energy expenditure, through adipokines modifications, with leptin decrease (high energy consumption) and adiponectin increase (optimization of energy expenditure). The exertion due to heavy effort induced a decrease of cortisol, while testosterone levels resulted unchanged. In conclusion, during a 3-weeks stage race, bone metabolism is pushed towards resorption. A possible relationship between the bone and the energy metabolisms is suggested by the relative correlations among absolute and relative concentrations trends of undercarboxylated OC, adipokines concentrations, BMI, fat mass (%), power output and the derived energy expenditure.

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“…Adipose tissue protects against injuries (15), and serves as a structural template for various organs. In the retro-orbital region, for example, the orbital structures, with adjacent supporting tissues, are embedded within such adipose tissue (16). All joints feature regions where adipose tissue projects into the bursal cavities as fatty pads; these pads are particularly evident in the shoulder, knee, and hip joints.…”

Section: Discussionmentioning

confidence: 99%

Determining residual adipose tissue characteristics with MRI in patients with various subtypes of lipodystrophy

Altay

Seçil²,

Demir³

et al. 2017

Diagn Interv Radiol

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Adipokine actions on cartilage homeostasis

Cited by 15 publications

References 69 publications

Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia

Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia

Bone and Energy Metabolism Parameters in Professional Cyclists during the Giro d’Italia 3-Weeks Stage Race

Determining residual adipose tissue characteristics with MRI in patients with various subtypes of lipodystrophy

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