Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

Maury, Eléonore; Brichard, Sonia

doi:10.1016/j.mce.2009.07.031

Cited by 891 publications

(711 citation statements)

References 228 publications

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“…Some adipokines such as leptin or resistin are produced in excess in obesity (98) , while others, such as adiponectin and ghrelin are reduced. This imbalance promotes pro-inflammatory responses and leads to inflammation (99)(100)(101) . A link between these adipokines was found in paediatric (102) and adult populations, with a stronger relationship observed in female, rather than male, individuals (41,103) .…”

Section: Possible Linksmentioning

confidence: 99%

Association between obesity and asthma – epidemiology, pathophysiology and clinical profile

2016

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Obesity is a risk factor for asthma, and obese asthmatics have lower disease control and increased symptom severity. Several putative links have been proposed, including genetics, mechanical restriction of the chest and the intake of corticosteroids. The most consistent evidence, however, comes from studies of cytokines produced by the adipose tissue called adipokines. Adipokine imbalance is associated with both proinflammatory status and asthma. Although reverse causation has been proposed, it is now acknowledged that obesity precedes asthma symptoms. Nevertheless, prenatal origins of both conditions complicate the search for causality. There is a confirmed role of neuro-immune cross-talk mediating obesityinduced asthma, with leptin playing a key role in these processes. Obesity-induced asthma is now considered a distinct asthma phenotype. In fact, it is one of the most important determinants of asthma phenotypes. Two main subphenotypes have been distinguished. The first phenotype, which affects adult women, is characterised by later onset and is more likely to be non-atopic. The childhood obesity-induced asthma phenotype is characterised by primary and predominantly atopic asthma. In obesity-induced asthma, the immune responses are shifted towards T helper (Th) 1 polarisation rather than the typical atopic Th2 immunological profile. Moreover, obese asthmatics might respond differently to environmental triggers. The high cost of treatment of obesity-related asthma, and the burden it causes for the patients and their families call for urgent intervention. Phenotype-specific approaches seem to be crucial for the success of prevention and treatment.

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Section: Possible Linksmentioning

confidence: 99%

Association between obesity and asthma – epidemiology, pathophysiology and clinical profile

2016

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“…It has been suggested that free fatty acids (FFAs) are the major link between obesity and insulin resistance [2]. An overload of FFAs leads to the activation of inflammatory pathways related to the induction of insulin resistance [3]. Recently, Boden et al [4] reported that FFAs activate the proinflammatory nuclear factor-κB (NF-κB) pathway in the rat liver and proposed an …”

Section: Introductionmentioning

confidence: 99%

Involvement of visfatin in palmitate-induced upregulation of inflammatory cytokines in hepatocytes

Choi

et al. 2011

Metabolism

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“…TNF-α in obese individual is produced by M1 macrophage from the stromal vascular fraction of adipose tissue [37,47,48]. TNF is high in obesity and has a role in the pathogenesis of IR [49] and metabolic syndrome [50].…”

Section: Tumor-necrosis Factor (Tnf)mentioning

confidence: 99%

“…It regulates insulin signaling and lipid metabolism in peripheral tissues along with its inflammation and host defense role [51]. Obesity, glucose intolerance and insulin resistance is positively correlated with increased IL-6 and can predict the development of T2DM, metabolic syndrome, and cardiovascular disease [47]. Weight loss reduces blood levels of IL-6 and also its expression by adipose tissue.…”

Section: Interleukin-6 (Il-6)mentioning

confidence: 99%

The Answer to Why Some Are Obese but Healthy?!

Dv¹

2018

J Obes Chronic Dis

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Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

Cited by 891 publications

References 228 publications

Association between obesity and asthma – epidemiology, pathophysiology and clinical profile

Association between obesity and asthma – epidemiology, pathophysiology and clinical profile

Involvement of visfatin in palmitate-induced upregulation of inflammatory cytokines in hepatocytes

The Answer to Why Some Are Obese but Healthy?!

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