The Answer to Why Some Are Obese but Healthy?!

Dv, Muralidhara

doi:10.17756/jocd.2018-016

Cited by 1 publication

(2 citation statements)

References 68 publications

(91 reference statements)

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“…Therefore, decreased fat mass and TNF-α level, suppression of the Nuclear Factor-kappaB (NF-kB) signaling pathway, and reduced insulin resistance induced by exercise can be the possible causes of the effect of exercise on the adiponectin level in obese girls [12,16,24,27,28]. In addition, adiponectin inhibits the infiltration of mono- cytes/macrophages into adipose tissue and converts them into foam cells in the vascular wall and thereby, reduces the PAI-1 level and inhibition of fibrinolysis [7,29].…”

Section: Resultsmentioning

confidence: 99%

“…Hypoadiponectinemia is an independent risk factor for metabolic syndrome in obese children and adolescents [6]. Adiponectin, mainly secreted by adipocytes, has anti-nociceptive, anti-inflammatory, anti-atherogenic, and anti-apoptotic characteristics [7]. Serum adiponectin levels are inversely correlated with the presence and severity of metabolic and neurological disorders as well as cardiovascular diseases [8].…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Regular Aerobic Exercise on the Serum levels of Plasminogen Activator Inhibitor-1 and Adiponectin in Obese Girls

Habibian

Mousavi

2019

J. Qazvin Univ. Med. Sci.

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Background The modulation of the adipokine levels can be important for the long-term prevention of systemic inflammation related to obesity in children. Objective The current study aimed to investigate the effects of regular aerobic exercise on the serum levels of plasminogen activator inhibitor-1(PAI-1) and Adiponectin in obese girls. Methods This quasi-experimental study conducted in 2014, 14 obese girls in Galikesh city, Iran who were selected by using purposive and convenience sampling techniques and randomly divided into two groups of control and exercise. Aerobic exercise consisted of exercise movements at 50-70% of maximum heart rate performed at 3 sessions per week for 8 weeks. Fasting blood samples were collected before and 48 hours after the last session of intervention. The PAI-1 and Adiponectin levels were measured by ELISA method. Data were analyzed by independent t-test and one-way analysis of covariance (ANCOVA). The significance level was set at P<0.05. Findings After 8 weeks of regular aerobic exercise, serum PAI-1 level and body weight significantly decreased in obese girls, whereas the serum adiponectin level was significantly increased (P<0.01). Conclusion findings suggest that regular aerobic exercise can modulate the adipokine levels in cardiovascular and inflammatory diseases by increasing the adiponectin level and downregulating the PAI-1 level and hence improve the health of obese girls.

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