The Effects of Regular Aerobic Exercise on the Serum levels of Plasminogen Activator Inhibitor-1 and Adiponectin in Obese Girls

Abstract

Background The modulation of the adipokine levels can be important for the long-term prevention of systemic inflammation related to obesity in children. Objective The current study aimed to investigate the effects of regular aerobic exercise on the serum levels of plasminogen activator inhibitor-1(PAI-1) and Adiponectin in obese girls. Methods This quasi-experimental study conducted in 2014, 14 obese girls in Galikesh city, Iran who were selected by using purposive and convenience sampling techniques and randomly divided into two groups of control and exercise. Aerobic exercise consisted of exercise movements at 50-70% of maximum heart rate performed at 3 sessions per week for 8 weeks. Fasting blood samples were collected before and 48 hours after the last session of intervention. The PAI-1 and Adiponectin levels were measured by ELISA method. Data were analyzed by independent t-test and one-way analysis of covariance (ANCOVA). The significance level was set at P<0.05. Findings After 8 weeks of regular aerobic exercise, serum PAI-1 level and body weight significantly decreased in obese girls, whereas the serum adiponectin level was significantly increased (P<0.01). Conclusion findings suggest that regular aerobic exercise can modulate the adipokine levels in cardiovascular and inflammatory diseases by increasing the adiponectin level and downregulating the PAI-1 level and hence improve the health of obese girls.

Weighted Vest Intervention during Whole-Body Circuit Training Improves Plasma Resistin, Cardiovascular Disease Risk Factors, and Cardiorespiratory Fitness in Normal-Weight Obese Women

“…In this study, the plasma resistin concentration was significantly decreased in both the WVCT and BWCT groups. In previous studies, plasma resistin concentration decreased mainly though aerobic and combined training [38,39] Aerobic exercise training by women in their 20s using a treadmill at 70 to 80 % HRmax, for eight weeks four times a week, was found to cause plasma resistin concentration to decrease [40]. Similarly, plasma resistin concentration was found to significantly decrease in a study of overweight adolescents undergoing aerobic training using a treadmill, rowing machine, and cycle ergometer at an intensity of 60 to 85% VO2max 3 times a week for eight weeks [41].…”