Adipokine profile in patients with anorexia nervosa

Abstract

Introduction: Anorexia nervosa (AN) is an eating disorder characterised with extremely low weight. Adipokines are adipose tissuederived substances that show a wide spectrum of biological activities. We aimed to assess selected adipokine levels in women with AN before and after nutritional intervention. We also sought to examine whether BMI is the only confounding factor influencing adipokine assessment in AN. Material and methods: Sixty-five women participated in the study: 20 individuals with AN before any treatment, 18 AN patients after nutritional intervention lasting for at least six months, and 27 women as controls. In all participants blood collection and anthropometric measurements were performed. ELISA was used for evaluation of leptin receptor, adiponectin and its isoforms, and resistin. Leptin was assessed with RIA, and visfatin was measured with EIA assay. Results: Leptin and free leptin index (FLI) were lowest in treatment-naïve AN women. HMW-adiponectin and visfatin were enhanced in AN. Other adipokine levels showed no significant differences. When two subsets of anorexia nervosa were compared, only leptin, leptin receptor, and FLI were markedly different. When data were adjusted to BMI, leptin and FLI remained significantly different in the pre-treated AN subgroup when compared with the control group. Conclusions: Our results suggest that leptin is the most important adipokine in AN. It is also important that in our AN population leptin and FLI are the only factors that are influenced not only by the fat content. (Endokrynol Pol 2017; 68 (4): 422-429)

Time course of adiponectin and its relationship to psychological aspects in patients with anorexia nervosa during inpatient treatment

“…However, there was no decrease of adiponectin dependent on increasing BMI in LSS patients as would have been predicted by this model. This finding is in line with a recent study that reported no difference in adiponectin levels between treatment naïve AN patients (mean BMI 15.6 ± 1.1 kg/m 2 ) and a group of re-fed AN patients [ 28 ]. A possible explanation may be given by the fact that the increase in BMI was considerably lower in LSS patients compared to HSS patients.…”

Anti-Inflammatory and Pro-Inflammatory Adipokine Profiles in Children on Vegetarian and Omnivorous Diets

“…The dysregulation of adipokine synthesis can alter homeostasis and lead to pathological conditions [ 8 ]. The majority of research has focused on obesity and its impact on the adipokine profile, although a few papers consider the adipokine pattern in an undernutrition state, such as anorexia nervosa [ 42 , 43 ]. Analyzing adipokine status, Mantovani et al [ 44 ] suggested that leptin, resistin, or adiponectin might be early markers of changing from lean to obesity, even before the occurrence of metabolic alterations.…”

Endokrynne implikacje otyłości i zabiegów bariatrycznych

“…Recent evidence has demonstrated that there are over 50 different adipokines secreted from adipose tissue [48][49][50][51]. The main processes regulated by adipokines may be divided into three groups: 1. lipids and glucose metabolism; 2. inflammatory processes; and 3. blood pressure and haemostasis.…”