Time course of adiponectin and its relationship to psychological aspects in patients with anorexia nervosa during inpatient treatment

Buckert, Magdalena; Stroe-Kunold, Esther; Friederich, Hans‐Christoph; Wesche, Daniela; Walter, Christiane; Kopf, Stefan; Simon, Joe J.; Herzog, Wolfgang; Wild, Beate

doi:10.1371/journal.pone.0189500

Cited by 9 publications

(5 citation statements)

References 48 publications

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“…In other words, ABA mice have relatively low levels of blood adiponectin, which diminishes the appetite-enhancing effects of adiponectin despite being hungry. In support of our speculation, Buckert et al [58] investigated temporal changes of the plasma adiponectin levels of AN patients with and without severe symptoms in a clinical intervention study, only observing hyperadiponectinemia in subjects with mild to moderate severity (BMI 16 or over) at the beginning. However, the plasma adiponectin level of severe AN patients (BMI under 16) increased in increments of BMI up to 16 during the treatment phase, then decreased with further weight gain.…”

Section: Plos Onesupporting

confidence: 64%

Modified activity-based anorexia paradigm dampens chronic food restriction-induced hyperadiponectinemia in adolescent female mice

Kuriyama,

Murata,

Ohtani

et al. 2023

PLoS ONE

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Anorexia nervosa (AN) is a chronic, life-threatening disease with mental and physical components that include excessive weight loss, persistent food restriction, and altered body image. It is sometimes accompanied by hyperactivity, day-night reversal, and amenorrhea. No medications have been approved specific to the treatment of AN, partially due to its unclear etiopathogenesis. Because adiponectin is an appetite-regulating cytokine released by adipose tissue, we hypothesized that it could be useful as a specific biomarker that reflects the disease state of AN, so we developed a modified AN mouse model to test this hypothesis. Twenty-eight 3-week-old female C57BL/6J mice were randomly assigned to the following groups: 1) no intervention; 2) running wheel access; 3) food restriction (FR); and 4) activity-based anorexia (ABA) that included running wheel access plus FR. After a 10-day cage adaptation period, the mice of the FR and ABA groups were given 40% of their baseline food intake until 30% weight reduction (acute FR), then the body weight was maintained for 2.5 weeks (chronic FR). Running wheel activity and the incidence of the estrous cycle were assessed. Spontaneous food restriction and the plasma adiponectin level were evaluated at the end of the acute and chronic FR phases. An increase in running wheel activity was found in the light phase, and amenorrhea was found solely in the ABA group, which indicates that this is a good model of AN. This group showed a slight decrease in spontaneous food intake accompanied with an attenuated level of normally induced plasma adiponectin at the end of the chronic FR phase. These results indicate that the plasma adiponectin level may be a useful candidate biomarker for the status or stage of AN.

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Section: Plos Onesupporting

confidence: 64%

Modified activity-based anorexia paradigm dampens chronic food restriction-induced hyperadiponectinemia in adolescent female mice

Kuriyama,

Murata,

Ohtani

et al. 2023

PLoS ONE

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“…Low levels of adiponectin were found in several psychiatric conditions, including severe depression (Carvalho et al 2014;Diniz et al 2012) and anxiety disorders (Unsal et al 2012). In addition, higher levels of adiponectin were significantly related to lower self-ratings of depression and anxiety but stress in patients with anorexia nervosa during inpatient treatment (Buckert et al 2017). In this cross-sectional study in a young Nigerian population, we did not see any significant association between ADIPOQ rs1501299 and psychological factors.…”

Section: Discussioncontrasting

confidence: 51%

ADIPOQ gene is linked to emotional eating behaviour in young Nigerian adults independent of psychological traits

2020

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Background A disturbance in eating behaviour (EB) is the hallmark of patients with eating disorders, and depicts a complex interaction of environmental, psychological and biological factors. In the present study, we propose a model of association of genetic susceptibility—represented by adiponectin (ADIPOQ) gene—with eating behavioural and psychological traits. Results Evaluation of the distribution of a polymorphism of the ADIPOQ (rs1501299 G > T) with respect to three EB factors involving cognitive restraint, uncontrolled eating and emotional eating revealed that T-allele in rs1501299 was associated with a decreased susceptibility to emotional EB in codominant (e.g., GG vs. TT) (beta-coefficient [β] = 2.39, 95% Confidence interval [CI] = − 4.02, − 0.76; p value [p] = 0.02), recessive (GG + GT vs. TT) (β = − 2.77, 95% CI = − 3.65, − 0.69; p = 0.005) and additive (GG = 0, GT = 1, TT = 2) (β = − 1.02, 95% CI = − 1.80, − 0.24; p = 0.01) models of inheritance. The presence of the T-allele was not significantly associated with psychological factors involving depression, anxiety and stress. Finally, none of the psychological traits significantly predicted any of the EB factors after controlling for age, body weight and gender. Conclusions Our data suggest that genetic variant in ADIPOQ locus may influence human emotional eating behaviour.

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“…gain in AN are a few, and the results are conflicting (Bosy-Westphal et al, 2005;Buckert et al, 2017;Modan-Moses et al, 2007). We need additional studies that explore the effects of re-feeding on adiponectin levels and other systems, such as bone and glucose metabolism and pro-inflammatory systems in AN.…”

Section: Discussionmentioning

confidence: 99%

“…Monitoring the changes in adiponectin levels during weight gain in patients with AN could provide valuable information to understand the underpinning biological mechanisms. Yet, the studies monitoring the changes in adiponectin levels before and after re‐feeding and weight gain in AN are a few, and the results are conflicting (Bosy‐Westphal et al, 2005; Buckert et al, 2017; Modan‐Moses et al, 2007). We need additional studies that explore the effects of re‐feeding on adiponectin levels and other systems, such as bone and glucose metabolism and pro‐inflammatory systems in AN.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin in anorexia nervosa and its modifiers: A meta‐regression study

Tural

Iosifescu

2022

Intl J Eating Disorders

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Objective: Adiponectin, which is secreted from adipose tissue, is a protein hormone.Although a large body of studies have found that circulating adiponectin levels increase in anorexia nervosa (AN) and caloric restriction, the effect of subtypes of AN and modifiers of adiponectin in AN are not yet known.Methods: A systematic search of electronic databases was performed using the search terms "adiponectin," "anorexia nervosa," and "eating disorder" up to January 2021. All studies published in peer-reviewed journals, which included cases and control groups, were selected. The main outcome was the pooled standardized mean difference (SMD) in adiponectin levels between cases and controls, using the random-effects model. Modifiers of SMD were tested via meta-regression. Heterogeneity and publication bias were evaluated.Results: Thirty-four studies met all eligibility criteria. The total sample of AN participants (Hedges' g = .765, p < .0001), and specifically the binge-eating/purging (Hedges' g = 1.211, p < .00001) and restrictive subtypes (Hedges' g = .913, p < .00001) of AN have increased adiponectin plasma levels compared with healthy controls. Meta-regression determined that insulin, IGF-1, BMI, triglyceride, resistin, glucose, IL-6 levels are significant modifiers of adiponectin levels.Discussion: Compared with controls, adiponectin levels are higher in AN overall, and specifically in the binge-eating/purging and the restrictive AN subtypes. Many of metabolic parameters of glucose metabolism and pro-inflammatory molecules modify the relationship between AN and adiponectin levels. Adipose tissue is important to maintain metabolic stability.Public Significance: Anorexia nervosa is a psychiatric disorder associated with a severe decrease in body weight and multiple metabolic abnormalities, including an increase in the hormone adiponectin. In this paper, we used meta-analysis, a powerful statistical method, to aggregate data from 34 rigorously selected research reports. This enabled us to understand the value of adiponectin to differentiate clinical subtypes of anorexia nervosa and the relations between adiponectin and other important metabolic parameters.

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Time course of adiponectin and its relationship to psychological aspects in patients with anorexia nervosa during inpatient treatment

Cited by 9 publications

References 48 publications

Modified activity-based anorexia paradigm dampens chronic food restriction-induced hyperadiponectinemia in adolescent female mice

Modified activity-based anorexia paradigm dampens chronic food restriction-induced hyperadiponectinemia in adolescent female mice

ADIPOQ gene is linked to emotional eating behaviour in young Nigerian adults independent of psychological traits

Adiponectin in anorexia nervosa and its modifiers: A meta‐regression study

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