Adipokines and Arterial Stiffness in Obesity

Para, Ioana; Albu, Adriana; Porojan, Mihai

doi:10.3390/medicina57070653

Cited by 32 publications

(26 citation statements)

References 205 publications

(246 reference statements)

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“…Previous studies have proved the correlation between obesity and arteriosclerosis. 18 19 Studies by Tang et al 8 and Vianna et al 9 demonstrated a positive correlation between BMI and baPWV, while studies by Rodrigues et al, 10 a Brazilian scholar, and Yang et al , 11 a Chinese scholar, advocated that BMI was negatively correlated with baPWV. Their results are apparently contradictory.…”

Section: Discussionmentioning

confidence: 99%

Cross-sectional association between body fat percentage and arteriosclerosis assessed by Cardio-Ankle Vascular Index in a Chinese population: a retrospective observational study

Bai

Liu

et al. 2022

BMJ Open

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ObjectiveTo evaluate arteriosclerosis using Cardio-Ankle Vascular Index (CAVI) and to explore the relation between the body fat percentage (BFP) and CAVI.DesignA retrospective observational study.Setting and participantsA total of 1152 patients admitted to a geriatric unit and general practice at a mega hospital in Wuhan, China, from November 2018 to November 2019 were included in this study.Primary outcomeAssociation between BFP and CAVI.ResultsMultiple linear regression analysis showed that BFP was positively correlated with CAVI after correction for potential confounding variables (β=0.03; 95% CI: 0.01 to 0.05); this association persisted after BFP was treated by quartile categorical variables and the trend test was statistically significant (p for trend=0.002). Meanwhile, the generalised additive model showed a non-linear association between BFP and CAVI. When BFP<20.6%, BFP is not associated with CAVI for (β=−0.02; 95% CI: −0.06 to 0.03), but when BFP≥20.6%, there is a linear positive association between BFP and CAVI (β=0.05; 95% CI: 0.02 to 0.07). Subgroup analysis showed that there was an interaction between BFP and CAVI in the age stratification (p interaction=0.038).ConclusionBFP was non-linearly correlated with CAVI, with a 0.05 increase in CAVI for every 1% increase in BFP when BFP≥20.6% and a 0.03 increase in CAVI in those >65 years of age.

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Section: Discussionmentioning

confidence: 99%

Cross-sectional association between body fat percentage and arteriosclerosis assessed by Cardio-Ankle Vascular Index in a Chinese population: a retrospective observational study

Bai

Liu

et al. 2022

BMJ Open

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“…Research has shown that hypoadiponectinemia is associated with obesity, insulin resistance, cardiovascular disease, dyslipidemia, hypertension, and metabolic syndrome [25]. In addition, adiponectin has antiatherogenic properties, as shown by its capacity to inhibit monocyte adhesion to endothelial cells and macrophage-tofoam cell transformation [26]. There are a limited number of studies investigating the association between alteration of adiponectin levels and AED usage.…”

Section: Discussionmentioning

confidence: 99%

Do antiepileptic drugs cause premature atherosclerosis by disturbing lipid metabolism?

2022

Ann Clin Anal Med

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Aim: The aim of this study was to evaluate susceptibility to atherosclerosis in epileptic patients on carbamazepine and valproic acid monotherapy with lipid profile, lipoprotein (a) (lp(a)), oxidized low-density lipoprotein (LDL), adiponectin, and carotid artery intima-media thickness measurements. Material and Methods: Of the 108 patients with epilepsy included in the study, 64 (36 female, 28 male) were receiving valproic acid monotherapy and 44 (25 female, 19 male) were receiving carbamazepine monotherapy. The control group comprised 48 (30 female, 18 male) healthy participants. Liver and kidney function tests, cholesterol, triglycerides, LDL, high-density lipoprotein (HDL), lp(a), oxidized LDL, adiponectin, and common carotid (CCA) and internal carotid artery (ICA) intima-media thickness (IMT) were investigated in both the patient and control groups. Results: Mean age was 32.34±12.41 years in the valproic acid group, 32.70±11.64 years in the carbamazepine group, and 35.81± 11.76 years in the control group. Liver and kidney function test results were normal in all groups. Cholesterol levels were lower in the valproic acid group than the other groups. HDL levels were higher in the carbamazepine group than other groups. Adiponectin levels were lower in the valproic acid group. In all groups, cholesterol and LDL levels were higher in individuals older than 50 years old. When the patients were evaluated according to the duration of drug use, cholesterol and LDL levels were higher in patients who had used drugs for more than 5 years in the valproic acid group. There were no differences between the groups for triglyceride, oxidized LDL, or lp(a) levels or CCA and ICA IMT. Discussion: There are conflicting results in the literature regarding epilepsy and atherosclerosis associated with antiepileptic drug usage. In this study, no evidence was found of an increasing risk of arteriosclerosis associated with antiepileptic drugs by measuring lipids, lipoprotein, oxidized LDL, adiponectin levels, and CCA and ICA IMT. However, it is important to monitor lipid levels in the follow-up of patients with epilepsy, especially for patients requiring longterm antiepileptic therapy and also older patients.

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“…Pro-inflammatory cytokines increase leptin synthesis and release, contributing to chronic inflammation in obesity. Obesity-induced hyperleptinemia stimulates the production of pro-inflammatory cytokines such as TNF-α, IL-6, IL-2, IL-1β, and interferon-γ (IFN-γ) by monocytes and T-helper 1, and also inhibits the production of the anti-inflammatory cytokine IL-4 [ 35 , 36 ]. Inflammation disrupts the signaling pathways triggered by leptin and contributes to the development of leptin resistance.…”

Section: Pro-inflammatory Adipokines In Obesity and Its Complicationsmentioning

confidence: 99%

The Role of Adipokines in Inflammatory Mechanisms of Obesity

Kirichenko

Markina

Bogatyreva

et al. 2022

IJMS

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Adipokines are currently widely studied cellular signaling proteins produced by adipose tissue and involved in various processes, including inflammation; energy and appetite modulation; lipid and glucose metabolism; insulin sensitivity; endothelial cell functioning; angiogenesis; the regulation of blood pressure; and hemostasis. The current review attempted to highlight the key functions of adipokines in the inflammatory mechanisms of obesity, its complications, and its associated diseases. An extensive search for materials on the role of adipokines in the pathogenesis of obesity was conducted online using the PubMed and Scopus databases until October 2022.

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Adipokines and Arterial Stiffness in Obesity

Cited by 32 publications

References 205 publications

Cross-sectional association between body fat percentage and arteriosclerosis assessed by Cardio-Ankle Vascular Index in a Chinese population: a retrospective observational study

Cross-sectional association between body fat percentage and arteriosclerosis assessed by Cardio-Ankle Vascular Index in a Chinese population: a retrospective observational study

Do antiepileptic drugs cause premature atherosclerosis by disturbing lipid metabolism?

The Role of Adipokines in Inflammatory Mechanisms of Obesity

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