Adipokines and their Relation to Endothelial Dysfunction in Patients with Chronic Kidney Disease

Ambarkar, Madhusudan; Pemmaraju, Srinivasarao V L N; Gouroju, S.; Manohar, Suchitra M.; Bitla, Aparna R.; Yajamanam, Naresh; Vishnubhotla, Sivakumar

doi:10.7860/jcdr/2016/15867.7060

Cited by 20 publications

(19 citation statements)

References 25 publications

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“…However, Malyszko et al 39 and Adamczak et al 44 reported increased levels of adiponectin in HD patients compared with those of the CRF or KT patient groups and KTR or control groups, respectively. In another study, Ambarkar et al 45 investigated adiponectin levels of CRF patients and reported reduced levels of adiponectin in those patients compared to the healthy subjects; however, those authors found an increment in adiponectin levels as the stage of the CRF advanced and suggested that the increment might be related to the progressed kidney dysfunction. Several studies reported a negative correlation between adiponectin and CRP levels in patients with Table 3.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure

2016

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Background: Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in patients with chronic kidney disease (CKD) including kidney transplant recipients (KTR). Secondary lipid metabolism disorders, endothelial dysfunction, and inflammation enhance the risk of CVD development in these patients. The aim of the present study was to investigate the lipid profile, adiponectin, leptin, nitric oxide (NO), and high sensitivity C-reactive protein (hs-CRP) levels in KTR and to compare these parameters with those of the patients with chronic renal failure (CRF), hemodialysis (HD) patients, and healthy controls. Methods: Serum adiponectin and leptin levels were measured by radioimmunoassay; hs-CRP was determined immunoturbidimetrically. Determination of NO was based on the Griess reaction. Results: Compared with the control group, serum NO and adiponectin levels were significantly higher in the KTR, CRF, and HD groups; hs-CRP levels were significantly higher in the KTR and HD groups; leptin levels were significantly higher in the KTR. In addition, serum NO level was significantly higher in the KTR compared to CRF cases. Adiponectin correlated positively with high density lipoprotein-cholesterol in the control and patient groups. A positive correlation was observed between hs-CRP and NO in the KTR and the patients with CRF. Serum adiponectin levels were inversely correlated with hs-CRP and leptin in the HD group. Conclusion: KTR suffer from inflammation and accompanying changes in levels of adipocytokines and NO which contribute to the increased risk of CVD in these patients.

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Section: Discussionmentioning

confidence: 99%

Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure

2016

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“… 16 , 17 , 18 , 19 , 20 , 21 The supporting data include the observation that CKD patients have elevated NEFA concentrations, an independent predictor of all-cause and cardiovascular death. 21 Furthermore, CKD patients have perturbed circulating adipokine concentrations 18 , 20 and increased systemic inflammation that correlates with fat mass. 16 Indeed, visceral fat mass in peritoneal dialysis patients is an independent predictor of vessel dysfunction and therefore a risk factor for CVD.…”

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confidence: 93%

Altered Protein Composition of Subcutaneous Adipose Tissue in Chronic Kidney Disease

Gertow

Branca

et al. 2017

Kidney International Reports

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IntroductionLoss of renal function is associated with high mortality from cardiovascular disease (CVD). Patients with chronic kidney disease (CKD) have altered circulating adipokine and nonesterified fatty acid concentrations and insulin resistance, which are features of disturbed adipose tissue metabolism. Because dysfunctional adipose tissue contributes to the development of CVD, we hypothesize that adipose tissue dysfunctionality in patients with CKD could explain, at least in part, their high rates of CVD. Therefore we characterized adipose tissue from patients with CKD, in comparison to healthy controls, to search for signs of dysfunctionality.MethodsBiopsy samples of subcutaneous adipose tissue from 16 CKD patients and 11 healthy controls were analyzed for inflammation, fibrosis, and adipocyte size. Protein composition was assessed using 2-dimensional gel proteomics combined with multivariate analysis.ResultsAdipose tissue of CKD patients contained significantly more CD68-positive cells, but collagen content did not differ. Adipocyte size was significantly smaller in CKD patients. Proteomic analysis of adipose tissue revealed significant differences in the expression of certain proteins between the groups. Proteins whose expression differed the most were α-1-microglobulin/bikunin precursor (AMBP, higher in CKD) and vimentin (lower in CKD). Vimentin is a lipid droplet−associated protein, and changes in its expression may impair fatty acid storage/mobilization in adipose tissue, whereas high levels of AMBP may reflect oxidative stress.DiscussionThese findings demonstrate that adipose tissue of CKD patients shows signs of inflammation and disturbed functionality, thus potentially contributing to the unfavorable metabolic profile and increased risk of CVD in these patients.

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“…On the other hand, since more than 90% of filtered urate is reabsorbed by the kidney, renal damage could affect this complex process, and in this context LPT may play a crucial role. Indeed, LPT may unfavourably contribute to the decline in renal function [7] both by a direct effect of nephron disruption and by an indirect effect though an inflammation status and a higher insulin resistance [20,21]. High LPT is involved in the promotion and progression of endothelial dysfunction and vascular damage, in particular it exerts the effects through glomerular endothelial cell proliferation, increased synthesis of collagen and hypertrophy of the mesangium cells [20,21], increased serum levels of adhesion molecules [20] and contributing to vascular remodelling [22].…”

Section: Introductionmentioning

confidence: 99%

Circulating leptin is associated with serum uric acid level and its tubular reabsorption in a sample of adult middle-aged men

D’Elia

Giaquinto

Cappuccio

et al. 2019

J Endocrinol Invest

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Adipokines and their Relation to Endothelial Dysfunction in Patients with Chronic Kidney Disease

Abstract: The present study demonstrates that adipokine levels are altered from initial to final stages of CKD due to renal dysfunction which in association with an exaggerated inflammation may contribute to the ED and CV events.

Cited by 20 publications

References 25 publications

Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure

Adiponectin, leptin, nitric oxide, and C-reactive protein levels in kidney transplant recipients: comparison with the hemodialysis and chronic renal failure

Altered Protein Composition of Subcutaneous Adipose Tissue in Chronic Kidney Disease

Circulating leptin is associated with serum uric acid level and its tubular reabsorption in a sample of adult middle-aged men

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