2013
DOI: 10.1016/b978-0-12-407766-9.00006-7
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Adipokines in Childhood Obesity

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Cited by 23 publications
(23 citation statements)
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References 175 publications
(206 reference statements)
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“…This fact recalls the earlier concept of a “hyperplasic” model of obesity in children versus a “hypertrophic” model in adults [53]. In the “hyperplasic” model, healthy adipose expansion with differentiation into small adipocytes and the presence of M2-like macrophages that help to maintain tissue homeostasis and preserve cellular functionality occurs [6,9,54].…”
Section: Discussionsupporting
confidence: 57%
See 1 more Smart Citation
“…This fact recalls the earlier concept of a “hyperplasic” model of obesity in children versus a “hypertrophic” model in adults [53]. In the “hyperplasic” model, healthy adipose expansion with differentiation into small adipocytes and the presence of M2-like macrophages that help to maintain tissue homeostasis and preserve cellular functionality occurs [6,9,54].…”
Section: Discussionsupporting
confidence: 57%
“…Finally, the dynamic secretions of adipokines, cortisol, and BDNF seem to be having different functions throughout growth and development during infancy, childhood and adulthood [40,53]. Therefore, it is important to note that, in spite of the fact that the early increase in levels of cortisol and adiponectin may partially protect against of low-grade inflammatory state in infancy, the long-term effect can predispose to other metabolic complications.…”
Section: Discussionmentioning
confidence: 99%
“…If growth hormone deficiency or insensitivity is suspected, serum insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) concentrations should be determined. Circulating concentrations of adiponectin, in particular its high-molecular-weight multimer, have been proposed as a possible indicator of the risk of developing alterations in carbohydrate metabolism because of its inverse relation with IR (24).…”
Section: Complementary Studiesmentioning
confidence: 99%
“…Además, estimula la expresión y transporte hacia la membrana celular del miocito, del transportador de glucosa número 4 (Glut-4, al tiempo que modula directamente la señalización del receptor de insulina. Por su parte, la estimulación del receptor adipoR2 hepático y la subsiguiente activación de la AMP-K inhiben la gluconeogénesis, mediante la modulación de la actividad de la glucosa-6-fosfatasa y de la fosfo-enol-piruvato descarboxilasa (9). El TAB también recibe la acción de la adiponectina, favoreciendo en él la diferenciación adipocitaria, la captación de glucosa, la oxidación de ácidos grasos y la actividad lipo-proteín-lipasa (71,72).…”
Section: Sensibilidad a Insulina: Papel De Adiponectina Visfatina Vunclassified
“…Dichas particularidades se extienden también a la síntesis y secreción de adipoquinas tanto el periodo fetal, como en la infancia y en la adolescencia, tres periodos de la vida caracterizados por una intensa tasa de crecimiento y desarrollo, así como por un mayor grado de plasticidad, tanto estructural como funcional de los tejidos, en comparación con la observada en la vida adulta (1,9). …”
Section: Introductionunclassified