2009
DOI: 10.1210/jc.2008-0701
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Adipokines, Inflammation, and Visceral Adiposity across the Menopausal Transition: A Prospective Study

Abstract: Women going through the menopausal transition have deleterious changes in inflammatory markers and adipokines that correlate with increased visceral adiposity.

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Cited by 238 publications
(172 citation statements)
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“…Women exhibit a tendency toward visceral fat accumulation during the menopausal transition, though it is difficult to separate the influence of menopause from the natural tendency toward fat accumulation with age 6, 28. Certainly, mice that are deficient in estradiol (because of a genetic deletion of the gene for aromatase) exhibit an increase in visceral fat and resultant insulin resistance compared with their wild‐type counterparts 29.…”
Section: Discussionmentioning
confidence: 99%
“…Women exhibit a tendency toward visceral fat accumulation during the menopausal transition, though it is difficult to separate the influence of menopause from the natural tendency toward fat accumulation with age 6, 28. Certainly, mice that are deficient in estradiol (because of a genetic deletion of the gene for aromatase) exhibit an increase in visceral fat and resultant insulin resistance compared with their wild‐type counterparts 29.…”
Section: Discussionmentioning
confidence: 99%
“…Very few randomized controlled trials (RCT) of exercise, independent of any dietary intervention, have studied these questions exclusively in postmenopausal women (22)(23)(24)(25)(26)(27), and findings were conflicting. Postmenopausal women represent a population subgroup that may respond differently to exercise given that female sex and older age have been associated with higher CRP levels (28) that may be partly related to a general increase in intraabdominal adiposity that occurs after menopause (29).…”
Section: Introductionmentioning
confidence: 99%
“…In the study, the subcutaneous adipose tissue increased in accordance with age independent of menopausal status, while the findings of increased visceral adipose tissue and total body fat were noted only in postmenopausal women. This distinctive physiologic change in amount and distribution of fat in women is noteworthy because the central fat deposition has a more deleterious effect on the development of cardiovascular and metabolic disease [24,25]. Although the exact mechanism regarding fat redistribution after menopause remains unclear, the phenomenon with declining estrogen level may be due to alterations in adipose tissue metabolism [4].…”
Section: Deposition and Distribution Of Adipose Tissuementioning
confidence: 99%