2014
DOI: 10.1016/j.tcm.2014.08.001
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Adiponectin and insulin cross talk: The microvascular connection

Abstract: Adiponectin exerts both vasodilatory and insulin-sensitizing actions and its levels are decreased in the insulin resistant humans and animals. The mechanisms underlying the adiponectin’s insulin-sensitizing effect have been extensively investigated but remain largely unclear. Muscle microvasculature critically regulates muscle insulin action by modulating insulin delivery to the microvessels nurturing the muscle cells and the trans-endothelial insulin transport. We have recently reported that adiponectin exert… Show more

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Cited by 26 publications
(22 citation statements)
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“…Adiponectin is a 28-kDa protein composed of 274 amino acids encoded by the AdipoQ gene. Adiponectin represents approximately 0.05% of the total plasma protein in humans, making it the most abundant adipocytokine synthesized by WAT [ 43 ]. Although adiponectin is not secreted by hepatocytes, or hepatic non-parenchymal cells, the two adiponectin receptors (AdipoR1 and 2) are expressed in liver, a major target for adiponectin.…”
Section: Adiponectin As An Anti-fibrogenic Cytokine and Adiponectin Bmentioning
confidence: 99%
“…Adiponectin is a 28-kDa protein composed of 274 amino acids encoded by the AdipoQ gene. Adiponectin represents approximately 0.05% of the total plasma protein in humans, making it the most abundant adipocytokine synthesized by WAT [ 43 ]. Although adiponectin is not secreted by hepatocytes, or hepatic non-parenchymal cells, the two adiponectin receptors (AdipoR1 and 2) are expressed in liver, a major target for adiponectin.…”
Section: Adiponectin As An Anti-fibrogenic Cytokine and Adiponectin Bmentioning
confidence: 99%
“…Indeed, blockade of insulin’s microvascular action with L-NAME decreases insulin-stimulated steady-state glucose disposal by up to 40% [46, 47]. In addition to insulin, other factors that are capable of increasing muscle microvascular blood volume and blood flow, such as mixed meal, muscle contraction, angiotensin 1-7, angiotensin II type 1 receptor blockers, glucagon-like peptide 1, ranolazine and adiponectin, are also capable of increasing insulin’s metabolic actions in muscle [41, 43, 48-56]. …”
Section: Insulin Acts On the Arterial Vasculature To Regulate Vessel mentioning
confidence: 99%
“…11 In the insulin-resistant humans and animals, 12 as well as in obesity and in the patients with T2DM, 13 the circulating levels of adiponectin are decreased. Therefore, hypoadiponectinemia is considered as an independent risk factor for T2DM and CVD development.…”
mentioning
confidence: 99%