Adiponectin and leptin gene variants and their effects on body weight trajectories in children from birth to 6 years of age: the PREDI Study

Kroll, Caroline; Farias, Dayana Rodrigues; Kac, Gilberto; França, Paulo Henrique Condeixa de; Mastroeni, Marco Fábio

doi:10.1017/s0007114520002780

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…The genotype GG of the ADIPOQ (rs2241766) polymorphism in the Crimean population was associated with hyperglycemia and increased levels of glycated hemoglobin, which is also associated with the greatest risk of developing DM2, as has been shown in the Russian population [ 24 ]. In contrast to the data, which also demonstrated the relationship of this genotype with hyperglycemia and increased levels of glycated hemoglobin, in Crimea, the GG genotype was not associated with hypercholesterolemia (as in Asian populations) [ 25 ] or an increase in BMI (as in European and Russian populations) [ 24 , 26 ]. We also established an association between this genotype and an increase in diastolic blood pressure, although European and Asian studies have not shown any relationship between the ADIPOQ (rs2241766) gene's GG genotype and an increase in systolic blood pressure [ 27 ].…”

Section: Discussioncontrasting

confidence: 78%

Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome

Shramko

Ageeva

Malyi

et al. 2022

Journal of Diabetes Research

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Abdominal obesity coupled with polygenic hereditary defects is considered the initial event in the development of metabolic syndrome (MS). The purpose of this study was to analyse the frequency with which polymorphic loci of adiponectin (ADIPOQ) and leptin (LEP) genes occur in patients with MS and the association between the symptoms of MS and these polymorphisms. DNA was isolated from the whole blood of 207 patients with MS and 100 healthy individuals (control group) using the phenol-chloroform method. Gene polymorphisms were determined using real-time polymerase chain reaction (PCR). The most common variant of the ADIPOQ (rs2241766) gene among MS patients was the GT genotype. The A allele of the LEP (rs7799039) gene was found to be the most frequent in MS patients. The highest systolic blood pressure was found in carriers of the GG genotype of the LEP (rs7799039) gene. The carriers of the ADIPOQ (rs2241766) GT genotype were associated with the highest systolic blood pressure and body mass index (BMI); carriers of the ADIPOQ (rs2241766) GG genotype were associated with the highest diastolic blood pressure, hyperglycaemia, and elevated glycated haemoglobin (HbA1c). The results of this study allowed us to establish the unique gene variants associated with the risk of developing MS in the Crimean population.

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Section: Discussioncontrasting

confidence: 78%

Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome

Shramko

Ageeva

Malyi

et al. 2022

Journal of Diabetes Research

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“…Much information on the importance of leptin in the pathogenesis of overweight and obesity comes from genetic studies. It is considered that sequence variants in the LEP gene may be involved in the pathomechanism of obesity development [ 63 ].…”

Section: Changes In the Lep Gene Sequence And The Risk Of Obesitymentioning

confidence: 99%

Leptin in Human Milk—One of the Key Regulators of Nutritional Programming

et al. 2022

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Breast milk is the optimal food for infants and toddlers, providing basic nutrients. It is also a source of many biologically active substances. Among them are hormones responsible for metabolic balance. One of the hormones taken in with breast milk by a breastfed baby is leptin. This hormone is involved in the regulation of appetite, informing the brain about the body’s energy resources. Having the correct mechanisms related to the action of leptin is a factor reducing the risk of obesity. The natural presence of leptin in the composition of breast milk suggests that it has a specific role in shaping the health of a breastfed child. Obesity as a disease of civilization affects more and more people, including children. The development of this disease is multifaceted and determined by many factors, including genetic and environmental factors such as eating habits and low physical activity. Behind obesity, there are complex mechanisms in which many elements of the human body are involved. Understanding the effects of breastfeeding as a natural source of leptin can help prevent childhood obesity and development of this disease in future life.

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Predictors of excess body weight concurrently affecting mother–child pairs: a 6 year follow-up

Czarnobay

Kroll

Corrêa

et al. 2021

Journal of Public Health

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Background We examined the predictors of excess body weight (EBW) concurrently affecting mother–child pairs after delivery during 6 years of follow-up. Methods Prospective cohort study conducted on 435 mother–child pairs. Data were collected at four time points: at birth in the maternity hospital; 1–2 years old, 4–5 years old and 6 years old at the participant’s home. Poisson regression analysis was used to examine the predictors of maternal–child EBW: mothers with excessive gestational weight gain (GWG) and large-for-gestational age (LGA) baby (>90th percentile) at baseline and mothers with body mass index (BMI) ≥ 25 kg/m2 and a child > 85th percentile. Results The adjusted analysis showed that the risk of mother–child pairs concurrently having EBW increased with increasing pre-pregnancy BMI (RR = 2.4 and RR = 3.3 for pre-pregnancy BMI 25–30 and ≥30 kg/m2, respectively, P < 0.01). Excessive GWG and LGA infants were also significant predictors of EBW concurrently affecting mother–child pairs (RR = 2.2 and RR = 2.3, respectively, P < 0.01). Conclusion Excessive pre-pregnancy BMI, excessive GWG and LGA status were strong predictors of EBW concurrently affecting mother–child pairs over 6 years of follow-up. Public policies must be established primarily before/during pregnancy to avoid an EBW cycle in the same family over the years.

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Adiponectin and leptin gene variants and their effects on body weight trajectories in children from birth to 6 years of age: the PREDI Study

Cited by 4 publications

References 46 publications

Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome

Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome

Leptin in Human Milk—One of the Key Regulators of Nutritional Programming

Predictors of excess body weight concurrently affecting mother–child pairs: a 6 year follow-up

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