Adiponectin as a Potential Biomarker for Pregnancy Disorders

Dias, Stephanie; Jack, Babalwa; Malaza, Nompumelelo; Adam, Sheryl

doi:10.3390/ijms22031326

Cited by 31 publications

(20 citation statements)

References 139 publications

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“…11 MetS is mainly comprised of obesity according to IDF 2005, whichin turn is related to low levels of serum adiponectin. 2,12,13 It was expected that serum adiponectin levels were low in obese (≥30 kg/m²), but it could not be proved in this study.…”

Section: Discussionmentioning

confidence: 65%

“…Apart from the effects of obesity and diabetes on adiponectin levels, pregnancy itself can lead to a decline in adiponectin levels due to gestational weight gain and normal hormonal changes leading to insulin resistance. 2 Similarly, low HDL levels and high TAG levels could be a part of normal physiological changes of pregnancy. 7 But as the adiponectin levels were low only in diabetic group, and HbA1c and HDL levels showed their effect on adiponectin levels, we could assume that merely pregnancy was not a predictor of adiponectin levels, and MetS had definitely played a role in decline of adiponectin levels in our study group.…”

Section: Discussionmentioning

confidence: 99%

“…This syndrome is comprised mainly of obesity according to IDF 2005 definition, and adiposity is related to low levels of serum adiponectin. 2 Hence, it was expected that low adiponectin levels could predict MetS and vice versa.…”

Section: Introductionmentioning

confidence: 99%

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Relationship of Adiponectin with Metabolic Syndrome Indicators in Pregnancy: A Cross-sectional Study

Akhtar¹,

Khan²,

Malik³

et al. 2022

IJCRR

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Introduction: Obesity, hyperglycemia, dyslipidemia and hypertension are indicators of metabolic syndrome (MetS). Low serum adiponectin levels might be able to predict MetS. Objective/Aim: This study was meant to assess relationship between MetS and adiponectin. Materials and Methods: In this cross-sectional study, women in their 24-40 weeks of pregnancy were selected. The study consisted of two groups, one group comprised 100 control, healthy pregnant women, while second group comprised 100 pregnant women with known gestational diabetes. Body mass index (BMI), and systolic and diastolic blood pressure participants were recorded. Blood was tested for HbA1c, HDL, triglycerides, and serum adiponectin levels. Results: BMI of 30% of participants was ≥30 kg/m², and 43% of the participants had HbA1c ≥6.5%. HDL levels were lower than normal in 30% of participants, and serum triglyceride levels were higher than normal in 78% of participants. SBP was higher than normal in 23% of the participants. Adiponectin level was low in >60% of cases. No statistically significant difference was found between the BMI of both groups. SBP and DBP were within normal limits in both groups. HbA1c levels were higher than normal, and HDL levels and adiponectin levels were lower than normal in the diabetic group. No statistically significant difference was found in TAG levels in both groups, and it was higher than normal in both groups. Regression analysis showed that adiponectin levels could predict diabetes and low HDL levels in our study. Conclusion: Hypoadiponectinemia could predict MetS indicators like hyperglycemia and low HDL levels.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

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Relationship of Adiponectin with Metabolic Syndrome Indicators in Pregnancy: A Cross-sectional Study

Akhtar¹,

Khan²,

Malik³

et al. 2022

IJCRR

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“…Several authors have studied the association between adiponectin and preeclampsia and found conflicting results. Most studies report an increase of adiponectin in the third trimester of gestation in patients with preeclampsia compared to control ( Pérez-Pérez et al, 2020 ; Pheiffer et al, 2021 ; Lara-Barea et al, 2022 ), while others found the Other adipokines such as resistin, visfatin and vaspin in gestational diabetes and preeclampsia have been described but their physiological role has yet to be established and work has been more descriptive regarding these other adipokines ( Miehle et al, 2012 ). In pregnant women plasma levels of resistin are elevated compared to non-pregnant women, however in gestational diabetes there are inconsistent data in the literature with some studies demonstrating elevation of resistin while others found decreased levels.…”

Section: Discussionmentioning

confidence: 99%

Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review

et al. 2022

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Background: Preeclampsia is a serious pregnancy complication that affects 5%–10% of the obstetric population.Objective: To study inflammatory markers associated with preeclampsia.Search Strategy: Searches of articles on the topic published over a 10-year period (2009–2019) were performed in three databases (PubMed, Cochrane, and Embase) using the keywords preeclampsia and inflammatory markers. The PubMed search using 10 years and humans as filters retrieved 124 articles. Using an advanced search strategy, 0 articles were identified in Embase and 10 articles in Cochrane. After screening and eligibility assessment, 13 articles were included in the systematic review and meta-analysis. Meta-analysis and quality assessment of the studies were performed using the Review Manager 5.3 program.Results: For meta-analysis, women with preeclampsia were compared to control women, i.e., pregnancies without arterial hypertension. Leptin levels were significantly higher (p < 0.0002) in women with preeclampsia compared to controls. Total cholesterol was also significantly elevated in women with preeclampsia (p < 0.0001). There was no significant difference in HDL between groups, but women with preeclampsia had significantly increased LDL (p < 0.01). The same was observed for triglycerides, which were significantly increased in women with preeclampsia (p < 0.04) compared to controls. Analysis of TNF-alpha, an important inflammatory marker, showed higher levels in women with preeclampsia (p < 0.03) compared to controls. The same was observed for another important inflammatory marker, interleukin 6, which was significantly increased in women with preeclampsia (p < 0.0002). There was a significant increase of C-reactive protein in women with preeclampsia (p < 0.003) compared to controls.Conclusion: Women with preeclampsia have increased levels of inflammatory markers compared to control women.

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“…Recently, the role of leptin stimulating IR and the inhibitory role of adiponectin have been emphasized [ 45 , 46 , 47 , 48 , 49 , 50 ]. The pathogenesis of GDM also takes into account the participation of less known molecules such as galectins, growth differentiation factor-15, chemerin, omentin-1, osteocalcin, resistin, visfatin, vaspin, irisin, apelin, Fatty Acid-Binding Protein 4 (FABP4), fibroblast growth factor 21, lipocalin-2, fetuin-A and zonulin [ 43 , 44 , 46 , 51 , 52 , 53 , 54 , 55 ]. IR is seen in GDM patients, as well as in impaired insulin secretion due to a defect in pancreatic-cell function [ 33 , 37 , 56 ].…”

Section: Pregnancy As a Window For The Development Of Metabolic Diseasesmentioning

confidence: 99%

Effects of Probiotic Supplementation during Pregnancy on the Future Maternal Risk of Metabolic Syndrome

Obuchowska

GORCZYCA

Standyło

et al. 2022

IJMS

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Probiotics are live microorganisms that induce health benefits in the host. Taking probiotics is generally safe and well tolerated by pregnant women and their children. Consumption of probiotics can result in both prophylactic and therapeutic effects. In healthy adult humans, the gut microbiome is stable at the level of the dominant taxa: Bacteroidetes, Firmicutes and Actinobacteria, and has a higher presence of Verrucomicrobia. During pregnancy, an increase in the number of Proteobacteria and Actinobacteria phyla and a decrease in the beneficial species Roseburia intestinalis and Faecalibacterium prausnitzii are observed. Pregnancy is a “window” to the mother’s future health. The aim of this paper is to review studies assessing the potentially beneficial effects of probiotics in preventing the development of diseases that appear during pregnancy, which are currently considered as risk factors for the development of metabolic syndrome, and consequently, reducing the risk of developing maternal metabolic syndrome in the future. The use of probiotics in gestational diabetes mellitus, preeclampsia and excessive gestational weight gain is reviewed. Probiotics are a relatively new intervention that can prevent the development of these disorders during pregnancy, and thus, would reduce the risk of metabolic syndrome resulting from these disorders in the mother’s future.

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Adiponectin as a Potential Biomarker for Pregnancy Disorders

Cited by 31 publications

References 139 publications

Relationship of Adiponectin with Metabolic Syndrome Indicators in Pregnancy: A Cross-sectional Study

Relationship of Adiponectin with Metabolic Syndrome Indicators in Pregnancy: A Cross-sectional Study

Association of LEPTIN and other inflammatory markers with preeclampsia: A systematic review

Effects of Probiotic Supplementation during Pregnancy on the Future Maternal Risk of Metabolic Syndrome

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