Adiponectin Gene Polymorphisms are Associated with Increased Risk of Colorectal Cancer

Abstract

BackgroundThis meta-analysis investigates the associations of adiponectin (ADIPOQ) genetic polymorphisms with the susceptibility to colorectal cancer (CRC).Material/Methods2 reviewers independently searched 6 databases – PubMed, Cochrane Library, Ovid, Embase, China National Knowledge Infrastructure (CNKI) and Wanfang databases – to identify published studies relevant to adiponectin gene polymorphisms and CRC. Studies retrieved from database searches were screened using our stringent inclusion and exclusion criteria. Full texts of the selected studies were accessed and related data was extracted using a standardized data extraction form. Comprehensive Meta-analysis 2.0 software was used for statistical analyses.ResultsA total of 188 studies were initially retrieved from database search, and 6 studies were eventually selected, through a rigorous screening process, for inclusion in this meta-analysis. The 6 studies contained a total of 1897 patients (Asians: 1190; white: 707) with CRC in case group and 2475 healthy controls (Asians: 1325; white: 1150) in the control group. Results of the current meta-analysis revealed that the rs2241766 T>G single-nucleotide polymorphisms (SNP) increase the risk of CRC; rs1501299 G>T under dominant model was associated with increased risk of CRC; and rs266729 C>G SNP under allele model conferred an increased risk of CRC.ConclusionsOur meta-analysis strongly suggests that the ADIPOQ rs2241766 T>G, rs1501299 G>T, and rs266729 C>G SNPs correlate with an increased risk of CRC.

Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies

“…In a genetic association meta-analysis, the minor alleles of three ADIPOQ SNPs (rs1501299, rs2241766, rs266729) were associated with colorectal cancer risk (32), but associations were only seen in Asians and not in Caucasians. Individual SNPs at the ADIPOQ loci (rs17300539, rs17366568, rs17366743, rs1501299, rs3774261 (the proxy SNPs rs2241766 was used in GECCO), rs6810075, rs266729, rs6773957, rs6444175, rs1063538), including those incorporated in the ADIPOQ allele score in the present study, were unrelated to risk of colorectal cancer in GECCO (11).…”

Obesity Biomarkers, Metabolism and Risk of Cancer: An Epidemiological Perspective

“…Studies on the association between genetic variants in the ADIPOQ gene and risk of colorectal cancer have produced diverse findings. In a meta-analysis including six case-control studies, three polymorphims in the ADIPOQ gene were associated with colorectal cancer, but associations were restricted to Asian populations while not seen in Caucasian populations [58]. In a pooled analysis of epidemiological studies on colorectal cancer where genetic markers were also available, polymorphisms in the ADIPOQ gene that have been identified in genome-wide association studies on adiponectin concentrations were not related to colorectal cancer risk [59], arguing against a causal contribution of adiponectin in the association between obesity and colorectal cancer.…”

Class III β-Tubulin in Colorectal Cancer: Tissue Distribution and Clinical Analysis of Chinese Patients

“…In China, colorectal carcinoma has been ranked as the fifth most common human malignant disease, accounting for 6.51% of mortality in urban areas and 4.64% in rural areas [2]. The etiology of colorectal cancers is known to be heterogeneous and various mechanisms have been associated with the increased risk for development and progression of colorectal carcinoma, as well as the aggressive behaviors of the tumors [3–5]. Tumors at the invasive front appear morphologically more poorly differentiated and show different molecular characteristics [6].…”