Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence

Abstract

Adiponectin, an adipocyte-secreted hormone that plays an important role in diabetes and cardiovascular disease, may also be of importance in the development and progression of several malignancies. Circulating adiponectin concentrations, which are determined mainly by genetic factors, nutrition, and adiposity, are lower in patients with breast, endometrial, prostate, and colon cancer. It has thus been proposed that adiponectin may be a biological link between obesity (especially central obesity) and increased cancer risk. Adiponectin may influence cancer risk through its well-recognized effects on insulin resistance, but it is also plausible that adiponectin acts on tumor cells directly. Several cancer cell types express adiponectin receptors that may mediate the effects of adiponectin on cellular proliferation. Herein, we review recent evidence supporting a role of serum adiponectin concentrations as a novel risk factor and possible diagnostic marker for obesity-related malignancies, including cancers of the breast, endometrium, colon, and prostate. Further studies are needed to fully elucidate the potential role of adiponectin in cancer diagnostics and therapeutics.

Adiponectin Receptor 1 (ADIPOR1) rs1342387 Polymorphism and Risk of Cancer: a Meta-analysis

“…Obesity is an established risk factor for various types of cancers (Renehan et al, 2008), and recent studies had shown that adiponectin was a key player in the development and progression of obesity-related cancers (Barb et al, 2007;Paz-Filho et al, 2011). Adiponectin implemented the main biological function through its receptors, which were believed to be also expressed in many types of cancers (Dalamaga et al, 2012).…”

“…Recent studies had revealed that adiponectin, the most abundant adiposetissue protein, was a key player in the development and progression of obesity-related cancers (Barb et al, 2007;Paz-Filho et al, 2011;Liu et al, 2013). Adiponectin is involved in anti-inflammatory, insulin-sensitizing, and anti-proliferation activities which are associated with the development of cancer (Barb et al, 2007;Ziemke and Mantzoros, 2010). Recent studies have confirmed that adiponectin implement the main biological function by signaling through its receptors-ADIPOR 1 and ADIPOR …”

“…Epidemiological studies had established that increasing of BMI and excess body weight were risk factors for some cancers, such as colorectal cancer, prostate cancer and renal cancer, which were called obesity-related cancers (Renehan et al, 2008;Vucenik and Stains, 2012). Recent studies had revealed that adiponectin, the most abundant adiposetissue protein, was a key player in the development and progression of obesity-related cancers (Barb et al, 2007;Paz-Filho et al, 2011;Liu et al, 2013). Adiponectin is involved in anti-inflammatory, insulin-sensitizing, and anti-proliferation activities which are associated with the development of cancer (Barb et al, 2007;Ziemke and Mantzoros, 2010).…”

“…Recent studies had revealed that adiponectin, the most abundant adiposetissue protein, was a key player in the development and progression of obesity-related cancers (Barb et al, 2007;Paz-Filho et al, 2011;Liu et al, 2013). Adiponectin is involved in anti-inflammatory, insulin-sensitizing, and anti-proliferation activities which are associated with the development of cancer (Barb et al, 2007;Ziemke and Mantzoros, 2010). Recent studies have confirmed that adiponectin implement the main biological function by signaling through its receptors-ADIPOR 1 and ADIPOR Li-Xiang Yu 1 , Nan-Nan Zhou 2 *, Li-Yuan Liu 3 , Fei Wang 1 , Zhong-Bing Ma 1 , Jie Li 4 , Zhi-Gang Yu 1 2 (Kim et al, 2010), which are expressed in various of malignancies including colorectal cancer, breast cancer, prostate cancer and so on (Kim et al, 2010;Dalamaga et al, 2012).…”

Overexpression of the adiponectin gene mimics the metabolic and stress resistance effects of calorie restriction, but not the anti-tumor effect

“…The plasma Adipoq concentration is reported to be inversely associated with a variety of human cancers (Barb, 2007), and these findings correlate with the increased risk of cancers in obese people. We therefore also tested whether or not overexpression of Adipoq inhibits tumor growth in an allograft tumor growth model (Yaker, 2006).…”