Adiponectin, lipids and atherosclerosis

Katsiki, Niki; Mantzoros, Christos S.; Mikhailidis, Dimitri P.

doi:10.1097/mol.0000000000000431

Cited by 146 publications

(97 citation statements)

References 132 publications

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“…After ADP binds to its receptor, the biological effects of ADP on insulin sensitivity seem to be mediated by its ability to activate AMPK, MAPK, and peroxisome proliferator-activated receptors-α signaling pathways, resulting in an increase of fatty acid oxidation and glucose uptake in muscle tissue, as well as an inhibition of gluconeogenesis in the liver [62]. In addition, ADP can also promote the production of endothelial nitric oxide to exert anti-atherosclerotic effects by improving the vascular dysfunction and inhibiting vascular inflammation [64,65]. With the deepening of research, it has been found that osteoblasts can express ADP and its receptors, and it can be concluded that ADP may be a key factor in metabolic bone disease [66].…”

Section: Oc and Exercisementioning

confidence: 99%

Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation

Yang

et al. 2019

Ann Nutr Metab

110

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Background: Exercise therapy plays an important role in the prevention and treatment of type 2 diabetes (T2DM). The mechanism of exercise therapy in the improvement of glycolipid metabolism of T2DM is very complex and not completely clear. Summary: Exercise training improves the whole body metabolic health in patients with T2DM, leading to an increase in glycolipid uptake and utilization, improved insulin sensitivity, optimized body mass index, and modulated DNA methylation, etc. Recent findings support that some cytokines such as irisin, osteocalcin, and adiponectin are closely related to exercise and metabolic diseases. This study briefly reviews the physiological mechanisms of exercise therapy in diabetes and the potential role of these cytokines in exercise. Key Messages: More high-quality, targeted, randomized controlled studies are needed urgently, from mechanism study to treatment direction, to provide a more theoretical basis for exercise therapy and to explore new therapeutic targets for diabetes.

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Section: Oc and Exercisementioning

confidence: 99%

Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation

Yang

et al. 2019

Ann Nutr Metab

110

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“…APN is well-known as a mediator in lipid metabolism. It is positively correlated with HDL-C and negatively associated with LDL cholesterol (LDL-C) and triglyceride concentrations (Katsiki et al, 2017). All evidences indicate that APN exerts a multifaceted effect in improving atherosclerosis in brain by regulating atherogenic factors.…”

Section: Atherosclerosismentioning

confidence: 97%

Links Between Adiponectin and Dementia: From Risk Factors to Pathophysiology

Chen

Shu

Zeng

2020

Front. Aging Neurosci.

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With the aging population, dementia is becoming one of the most serious and troublesome global public health issues. Numerous studies have been seeking for effective strategies to delay or block its progression, but with little success. In recent years, adiponectin (APN) as one of the most abundant and multifunctional adipocytokines related to anti-inflammation, regulating glycogen metabolism and inhibiting insulin resistance (IR) and anti-atherosclerosis, has attracted widespread attention. In this article, we summarize recent studies that have contributed to a better understanding of the extent to which APN influences the risks of developing dementia as well as its pathophysiological progression. In addition, some controversial results interlinked with its effects on cognitive dysfunction diseases will be critically discussed. Ultimately, we aim to gain a novel insight into the pleiotropic effects of APN levels in circulation and suggest potential therapeutic target and future research strategies.

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“…Relative to insulin‐resistant obese adolescents, insulin‐sensitive obese adolescents demonstrate higher circulating adiponectin, an anti‐inflammatory adipocytokine . Whilst glucose, insulin, and HbA1c concentrations are important diagnostic biomarkers of T2D, adiponectin, and to a greater extent its high‐molecular‐weight (HMW) oligomeric complex, are also early and sensitive biochemical predictors of future T2D . Indeed, in overweight and obese adolescents, hypoadiponectinemia was demonstrated to precede cardio‐metabolic dysregulation by 6 years .…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, in overweight and obese adolescents, hypoadiponectinemia was demonstrated to precede cardio‐metabolic dysregulation by 6 years . Furthermore, despite normal fasting glucose and HbA1c levels, obese adolescents with insulin‐resistance as measured by hyperinsulinemic‐euglycemic clamp demonstrated deranged serum adiponectin …”

Section: Introductionmentioning

confidence: 99%

Personalized Cardio‐Metabolic Responses to an Anti‐Inflammatory Nutrition Intervention in Obese Adolescents: A Randomized Controlled Crossover Trial

McMorrow

Connaughton

Magalhães

et al. 2018

Molecular Nutrition Food Res

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ScopeChronic inflammation and hypoadiponectinemia are characteristics of obesity‐induced insulin resistance (IR). The effect of an anti‐inflammatory nutrition supplement (AINS) on IR and adiponectin biology in overweight adolescents was investigated. The secondary objective was to examine the extent to which individuals’ biomarker profiles, derived from baseline phenotypes, predicted response or not to the AINS. Additionally, the impact of DNA methylation on intervention efficacy was assessed.Methods and resultsSeventy overweight adolescents (13–18 years) were recruited to this randomized controlled crossover trial. Participants received an AINS (long chain n‐3 PUFA, vitamin C, α‐tocopherol, green tea extract, and lycopene) and placebo for 8 weeks each. Homeostatic model assessment (HOMA)‐IR, adiponectin, inflammatory profiles, and DNA methylation were assessed. HOMA‐IR was unchanged in the total cohort. High‐molecular‐weight (HMW) adiponectin was maintained following the AINS while it decreased over time following the placebo intervention. HOMA‐IR decreased in 40% of subjects (responders) following the AINS. Responders’ pretreatment phenotype was characterized by higher HOMA‐IR, total and LDL cholesterol, but similar BMI in comparison to nonresponders. HMW adiponectin response to the AINS was associated with bidirectional modulation of adipogenic gene methylation.ConclusionThe AINS modulated adiponectin biology, an early predictor of type 2 diabetes risk, was associated with bidirectional modulation of adipogenic gene methylation in weight‐stable overweight adolescents. HOMA‐IR decreased in a sub‐cohort of adolescents with an adverse metabolic phenotype. Thus, suggesting that more stratified or personalized nutrition approaches may enhance efficacy of dietary interventions.

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Adiponectin, lipids and atherosclerosis

Cited by 146 publications

References 132 publications

Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation

Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation

Links Between Adiponectin and Dementia: From Risk Factors to Pathophysiology

Personalized Cardio‐Metabolic Responses to an Anti‐Inflammatory Nutrition Intervention in Obese Adolescents: A Randomized Controlled Crossover Trial

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