Adipose ABCG1: A potential therapeutic target in obesity?

Frisdal, Éric; Goff, Wilfried Le

doi:10.1080/21623945.2015.1023491

Cited by 14 publications

(8 citation statements)

References 17 publications

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“…An intriguing related observation is that the expression of Abcg1 was substantially increased, but that of Ces1f in eWAT and triacylglycerol levels in plasma were significantly decreased after spaceflight. Although ABCG1 is best known as a cholesterol transporter, studies of Abcg1 knockout mice revealed that ABCG1 also plays important roles in FA transport and lipid storage in adipocytes 40 – 42 . CES1F hydrolyses triacylglycerols 43 , 44 .…”

Section: Discussionmentioning

confidence: 99%

Nrf2 plays a critical role in the metabolic response during and after spaceflight

et al. 2021

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Space travel induces stresses that contribute to health problems, as well as inducing the expression of Nrf2 (NF-E2-related factor-2) target genes that mediate adaptive responses to oxidative and other stress responses. The volume of epididymal white adipose tissue (eWAT) in mice increases during spaceflight, a change that is attenuated by Nrf2 knockout. We conducted metabolome analyses of plasma from wild-type and Nrf2 knockout mice collected at pre-flight, in-flight and post-flight time points, as well as tissues collected post-flight to clarify the metabolic responses during and after spaceflight and the contribution of Nrf2 to these responses. Plasma glycerophospholipid and sphingolipid levels were elevated during spaceflight, whereas triacylglycerol levels were lower after spaceflight. In wild-type mouse eWAT, triacylglycerol levels were increased, but phosphatidylcholine levels were decreased, and these changes were attenuated in Nrf2 knockout mice. Transcriptome analyses revealed marked changes in the expression of lipid-related genes in the liver and eWAT after spaceflight and the effects of Nrf2 knockout on these changes. Based on these results, we concluded that space stress provokes significant responses in lipid metabolism during and after spaceflight; Nrf2 plays critical roles in these responses.

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Section: Discussionmentioning

confidence: 99%

Nrf2 plays a critical role in the metabolic response during and after spaceflight

et al. 2021

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“…ABCA1 участвует в биогенезе ЛПВП на этапе формирования незрелых частиц пре-b-ЛПВП, в то время как ABCG1 осуществляет насыщение холестерином зрелых ЛПВП [8]. Согласно данным ряда исследований, именно транспортер ABCG1 является основным регулятором содержания холестерина в жировой ткани; он играет важную роль в адипогенезе и вовлечен в молекулярные механизмы накопления триглицеридов в адипоцитах [7][8][9][10][11]. В то же время есть данные, что транспортер ABCA1 может принимать участие в синтезе ЛПВП в жировой ткани [3].…”

Section: Introductionunclassified

Regulation of ABCA1 and ABCG1 gene expression in the intraabdominal adipose tissue

et al. 2016

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Tissue specific expression of genes encoding cholesterol transporters ABCA1 and ABCG1 as well as genes encoding the most important transcriptional regulators of adipogenesis – LXRa, LXRb, PPARg and RORa has been investigated in intraabdominal adipose tissue (IAT) samples.A direct correlation between the content of ABCA1 and ABCG1 proteins with RORa protein level (r=0.480, p<0.05; r=0.435, p<0.05, respectively) suggests the role of the transcription factor RORa in the regulation of IAT ABCA1 and ABCG1 protein levels. ABCA1 and ABCG1 gene expression positively correlated with obesity indicators such as body mass index (BMI) (r=0.522, p=0.004; r=0.594, p=0.001, respectively) and waist circumference (r=0.403, p=0.033; r=0.474, p=0.013, respectively). The development of obesity is associated with decreased IAT levels of RORa and LXRb mRNA (p=0.016 and p=0.002, respectively). These data suggest that the nuclear factor RORa can play a significant role in the regulation of cholesterol metabolism and control IAT expression of ABCA1 and ABCG1, while the level of IAT LXRb gene expression may be an important factor associated with the development of obesity.

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“…Frisdal et al (2015) found that ABCG1 gene absence protects mice against diet-induced obesity. The mechanism explained by Frisdal and Le Goff (2015) is that the ABCG1 protein influences the lipoprotein lipase (LPL) function, altering its triacylglycerol-rich lipoproteins hydrolyzation efficiency, leading to altered lipid accumulation in adipocytes. This role meets with the fact that ABCG1 upregulated expression leads to an increase in the fat mass ( Frisdal et al , 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Is it possible ABC transporters genetic variants influence the outcomes of a weight-loss diet in obese women?

et al. 2020

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ATP-Binding Cassette (ABC) transporters are involved in cholesterol metabolism and their dysfunctions could lead to obesity-associated complications. It was investigated whether SNPs in the ABCA1 (rs1800977 and rs2230806), ABCA7 (rs2279796) and ABCG1 (rs692383 and rs3827225) genes can modulate the responsiveness of 137 obese women to a weight-loss dietary intervention. Thus, anthropometric and lipid profiles were collected at baseline and after nine weeks of a calorie-restricted diet of 600kcal per day and participants were genotyped for the ABC genes SNPs. Regarding the transversal analysis, the ABCA7 rs2279796 GG genotype was associated with higher levels of total cholesterol and LDL-c at baseline (p = 0.044 for both). Association between ABCG1 rs692383 AA genotype and lower BMI were found in the post-diet moment, however, statistical significance was lost after multi-test correction. Regarding the longitudinal analysis, after multi-test correction, the association remained between ABCG1 rs692383 G allele and HDL-c levels: G allele carriers had a lower HDL-c reduction (p = 0.043). Results suggest the standard weight-loss diet applied in this study could attenuate the ABCA7 rs2279796 GG genotype effects found at baseline and non-dyslipidemic obese women with ABCG1 rs692383 G allele are benefitting from the diet with a lower reduction in HDL-c levels.

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Adipose ABCG1: A potential therapeutic target in obesity?

Cited by 14 publications

References 17 publications

Nrf2 plays a critical role in the metabolic response during and after spaceflight

Nrf2 plays a critical role in the metabolic response during and after spaceflight

Regulation of ABCA1 and ABCG1 gene expression in the intraabdominal adipose tissue

Is it possible ABC transporters genetic variants influence the outcomes of a weight-loss diet in obese women?

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