Regulation of ABCA1 and ABCG1 gene expression in the intraabdominal adipose tissue

Miroshnikova, V. V.; Пантелеева, А. А.; Баженова, Е. А.; Demina, E. P.; Usenko, T.; Nikolaev,; Semenova, I.; Neimark, A. E.; He, Jia; Belyaeva, O.; Беркович, О. А.; Баранова, Е. И.; Pchelina, Sofya

doi:10.18097/pbmc20166203283

Cited by 9 publications

(5 citation statements)

References 32 publications

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“…Notably, ABCA1, another member of this gene family, has also been robustly linked to the control of HDL and TC levels through GWAS 36 . We replicate the previously reported association between ABCG1 methylation and ABCG1 expression 37 and note that expression levels of ABCG1 have also been found to be positively correlated with obesity 38 . Lastly, the methylation status of cg06500161 in ABCG1 is associated with an elevated risk of developing type 2 diabetes 39 while genetic variants mapped to this locus are linked to atherosclerosis 40,41 .…”

Section: Discussionsupporting

confidence: 90%

A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids

et al. 2021

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Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglycerides, a modest overlap of associations with epigenome-wide association studies of other cardio-metabolic traits, and a largely non-overlap with lipid loci identified to date through genome-wide association studies. Thirty CpGs reached significance in at least 2 racial/ethnic groups including 7 that showed association with the expression of an annotated gene. CpGs annotated to CPT1A showed evidence of being influenced by triglycerides levels. DNA methylation levels of circulating leukocytes show robust and consistent association with blood lipid levels across multiple racial/ethnic groups.

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Section: Discussionsupporting

confidence: 90%

A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids

et al. 2021

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“…The following supporting information can be downloaded at: https:// www.mdpi.com/article/10.3390/ijms25126457/s1, references [25,[48][49][50][51][52][53] are cited in Supplementary Materials.…”

Section: Supplementary Materialsmentioning

confidence: 99%

“…The following supporting information can be downloaded at: , references [ 25 , 48 , 49 , 50 , 51 , 52 , 53 ] are cited in Supplementary Materials.…”

mentioning

confidence: 99%

Extracellular Vesicles Secreted by Adipose Tissue during Obesity and Type 2 Diabetes Mellitus Influence Reverse Cholesterol Transport-Related Gene Expression in Human Macrophages

Dracheva,

Pobozheva,

Anisimova

et al. 2024

IJMS

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Obesity is a risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Adipose tissue (AT) extracellular vesicles (EVs) could play a role in obesity and T2DM associated CVD progression via the influence of their specific cargo on gene expression in recipient cells. The aim of this work was to evaluate the effects of AT EVs of patients with obesity with/without T2DM on reverse cholesterol transport (RCT)-related gene expression in human monocyte-derived macrophages (MDMs) from healthy donors. AT EVs were obtained after ex vivo cultivation of visceral and subcutaneous AT (VAT and SAT, respectively). ABCA1, ABCG1, PPARG, LXRβ (NR1H2), and LXRα (NR1H3) mRNA levels in MDMs as well as in origine AT were determined by a real-time PCR. T2DM VAT and SAT EVs induced ABCG1 gene expression whereas LXRα and PPARG mRNA levels were simultaneously downregulated. PPARG mRNA levels also decreased in the presence of VAT EVs of obese patients without T2DM. In contrast ABCA1 and LXRβ mRNA levels tended to increase with the addition of obese AT EVs. Thus, AT EVs can influence RCT gene expression in MDMs during obesity, and the effects are dependent on T2DM status.

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“…Two ABC transporters, ABCA1 and ABCG1, being essential components of RCT, are important contributors to the processes of HDL biogenesis and particle maturation. Liver X receptors α/β (LXRα/β) agonists, as well as ligands for peroxisome proliferator-activated receptors (PPARs), are recognized as the main regulators of ABCA1 and ABCG1 gene expression in macrophages, hepatocytes, fibroblasts, and intestinal cells, while the transcription factor retinoic-acid-related orphan receptor α (RORα) regulates the expression of these transporters in intraabdominal adipose tissue [128][129][130][131]. In addition, apart from ABCA1 and ABCG1 regulation of HDL metabolism, their corresponding subfamilies are involved in the development of resistance to chemotherapeutics [132].…”

Section: Abc Transportersmentioning

confidence: 99%

Revealing the Role of High-Density Lipoprotein in Colorectal Cancer

Zeljković

Mihajlović

Gojković

et al. 2021

IJMS

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Colorectal cancer (CRC) is a highly prevalent malignancy with multifactorial etiology, which includes metabolic alterations as contributors to disease development. Studies have shown that lipid status disorders are involved in colorectal carcinogenesis. In line with this, previous studies have also suggested that the serum high-density lipoprotein cholesterol (HDL-C) level decreases in patients with CRC, but more recently, the focus of investigations has shifted toward the exploration of qualitative properties of HDL in this malignancy. Herein, a comprehensive overview of available evidences regarding the putative role of HDL in CRC will be presented. We will analyze existing findings regarding alterations of HDL-C levels but also HDL particle structure and distribution in CRC. In addition, changes in HDL functionality in this malignancy will be discussed. Moreover, we will focus on the genetic regulation of HDL metabolism, as well as the involvement of HDL in disturbances of cholesterol trafficking in CRC. Finally, possible therapeutic implications related to HDL will be presented. Given the available evidence, future studies are needed to resolve all raised issues concerning the suggested protective role of HDL in CRC, its presumed function as a biomarker, and eventual therapeutic approaches based on HDL.

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Regulation of ABCA1 and ABCG1 gene expression in the intraabdominal adipose tissue

Cited by 9 publications

References 32 publications

A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids

A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids

Extracellular Vesicles Secreted by Adipose Tissue during Obesity and Type 2 Diabetes Mellitus Influence Reverse Cholesterol Transport-Related Gene Expression in Human Macrophages

Revealing the Role of High-Density Lipoprotein in Colorectal Cancer

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