Adipose-derived mesenchymal stem cells in biosutures do not improve healing of experimental colonic anastomoses

Abstract

ASC biosutures have no effect on anastomotic healing in rats.

Mesenchymal stem cells improve the healing of ischemic colonic anastomoses (experimental study)

“…BMMSCs from several sites, including bone marrow and adipose tissue, may have immunomodulatory properties, thereby indicating a possible use for BM-MSCs in regenerative medicine and tissue engineering [6][7][8][9]. BMMSCs have the ability to differentiate into several cell types, including osteoblasts, chondroblasts, fibroblasts, adipocytes, skeletal myoblasts, cardiomyocytes, and endothelial cells [7,10].…”

Systematic Review of the Technique of Colorectal Anastomosis

“…21,22 Two included randomized controlled trials (RCTs) 23,24 on suture material failed to achieve a unanimous conclusion because of the small number of patients included and the different suture materials tested that are rarely used today.…”

Mast Cell Degranulation is Essential for Anastomotic Healing in Well Perfused and Poorly Perfused Rat Colon

“…A moderate improvement was shown by the use of colloid resuscitation postoperatively in rats [16]. Platelet rich plasma showed no benefit in a pig model [17], and sutures impregnated with stem cells showed no benefit in a rat model [18]. No study to date has attempted to promote mast cell degranulation to aid healing.…”