Adipose-derived stem cells and obesity: The spear and shield relationship

Yang, Hong; Li, Chaowei; Li, Yizhou; Tai, Ruiqing; Sun, Cheng

doi:10.1016/j.gendis.2021.09.004

Cited by 6 publications

(2 citation statements)

References 144 publications

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“…Stem cell or brown adipose tissue transplantation, cell lysates, and exosomes have been tested in obese mouse models [104,105]. Overall, ADSCs were found to be effective in treating obesity-associated diabetes and inflammation and protective against cardiovascular disease [106,107]. Therefore, stem cell therapy represents a promising treatment strategy for obesity and obesity-related comorbidities [108].…”

Section: Obesity and Obesity-related Metabolic Syndromementioning

confidence: 99%

Management of Obesity and Obesity-Related Disorders: From Stem Cells and Epigenetics to Its Treatment

Cruciani

Delitala

Cossu

et al. 2023

IJMS

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Obesity is a complex worldwide disease, characterized by an abnormal or excessive fat accumulation. The onset of this pathology is generally linked to a complex network of interactions among genetic and environmental factors, aging, lifestyle, and diets. During adipogenesis, several regulatory mechanisms and transcription factors are involved. As fat cells grow, adipose tissue becomes increasingly large and dysfunctional, losing its endocrine function, secreting pro-inflammatory cytokines, and recruiting infiltrating macrophages. This long-term low-grade systemic inflammation results in insulin resistance in peripheral tissues. In this review we describe the main mechanisms involved in adipogenesis, from a physiological condition to obesity. Current therapeutic strategies for the management of obesity and the related metabolic syndrome are also reported.

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Section: Obesity and Obesity-related Metabolic Syndromementioning

confidence: 99%

Management of Obesity and Obesity-Related Disorders: From Stem Cells and Epigenetics to Its Treatment

Cruciani

Delitala

Cossu

et al. 2023

IJMS

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“…Recent studies show that both in mice and humans, there is a correlation between obesity and impaired ASCs migration, proliferation, and angiogenic potential, hence reducing the therapeutic potential of these cells [ 8 ]. Therefore, given the association of ASCs with metabolic disorders such as obesity and obesity-related metabolic diseases, methods for positive ASC stimulation and promotion of positive differentiation are being carefully studied [ 9 , 10 ]. Substantial research efforts have also been undertaken to unravel the correlation between increased ER stress in ASC and conditions such as obesity or insulin resistance [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Tetrahydrocannabivarin (THCV) Protects Adipose-Derived Mesenchymal Stem Cells (ASC) against Endoplasmic Reticulum Stress Development and Reduces Inflammation during Adipogenesis

Kowalczuk

Marycz

Kornicka

et al. 2023

IJMS

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The endoplasmic reticulum (ER) fulfills essential duties in cell physiology, and impairment of this organelle’s functions is associated with a wide number of metabolic diseases. When ER stress is generated in the adipose tissue, it is observed that the metabolism and energy homeostasis of the adipocytes are altered, leading to obesity-associated metabolic disorders such as type 2 diabetes (T2D). In the present work, we aimed to evaluate the protective effects of Δ9-tetrahydrocannabivarin (THCV, a cannabinoid compound isolated from Cannabis sativa L.) against ER stress in adipose-derived mesenchymal stem cells. Our results show that pre-treatment with THCV prevents the subcellular alteration of cell components such as nuclei, F-actin, or mitochondria distribution, and restores cell migration, cell proliferation and colony-forming capacity upon ER stress. In addition, THCV partially reverts the effects that ER stress induces regarding the activation of apoptosis and the altered anti- and pro-inflammatory cytokine profile. This indicates the protective characteristics of this cannabinoid compound in the adipose tissue. Most importantly, our data demonstrate that THCV decreases the expression of genes involved in the unfolded protein response (UPR) pathway, which were upregulated upon induction of ER stress. Altogether, our study shows that the cannabinoid THCV is a promising compound that counters the harmful effects triggered by ER stress in the adipose tissue. This work paves the way for the development of new therapeutic means based on THCV and its regenerative properties to create a favorable environment for the development of healthy mature adipocyte tissue and to reduce the incidence and clinical outcome of metabolic diseases such as diabetes.

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Adipocyte‐Targeted Nanotechnology and Cell‐Based Therapy for Obesity Treatment

Wu,

Deng,

Wei

et al. 2024

ChemMedChem

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Obesity is a critical risk factor for the development of metabolic diseases and is often associated with dysfunctional adipocytes. Prevalent treatments such as lifestyle intervention, pharmacotherapy, and bariatric surgery are often accompanied by adverse side effects and poor patient compliance. Nanotechnology and cell‐based therapy offer innovative approaches for targeted obesity treatments, as they can directly target adipocytes, regulate lipid metabolism, and minimize off‐target effects. Here, we provide an overview of the intricate relationship between adipocytes and obesity, highlighting the potential of nanotechnology and cell‐based therapy in obesity treatment. Additionally, we discuss the advancements of adipose‐derived mesenchymal stem cells (ADMSCs) in obesity progression, including the latest challenges and considerations for developing adipose‐targeted treatments for obesity. The objective is to provide a perspective on the design and development of nanotechnology and cell‐based therapy for treating obesity and related comorbidities.

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Adipose-derived stem cells and obesity: The spear and shield relationship

Cited by 6 publications

References 144 publications

Management of Obesity and Obesity-Related Disorders: From Stem Cells and Epigenetics to Its Treatment

Management of Obesity and Obesity-Related Disorders: From Stem Cells and Epigenetics to Its Treatment

Tetrahydrocannabivarin (THCV) Protects Adipose-Derived Mesenchymal Stem Cells (ASC) against Endoplasmic Reticulum Stress Development and Reduces Inflammation during Adipogenesis

Adipocyte‐Targeted Nanotechnology and Cell‐Based Therapy for Obesity Treatment

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