Adipose-Derived Stem Cells Improve Survival of Random Pattern Cutaneous Flaps in Radiation Damaged Skin

Hasdemir, Mustafa; Ağır, Hakan; Eren, Guler Gamze; Aksu, Maksut Görkem; Alagöz, Murat Şahin; Duruksu, Gökhan; Sağlam, Özlem; Karaöz, Erdal

doi:10.1097/scs.0000000000001852

Cited by 17 publications

(15 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the tissue involving the fistula was expected to be poorly vascularized and fibrotic due to previous operations and radiation injury, we tried to assist the healing process by injecting SVF. Hasdemir et al [11] experimentally showed that adipose-derived stem cells improved skin flap survival and a similar approach was undertaken for this case. Considering that no bulky lipotransfer was carried out in this caseinstead, only a thin mucosal flap was used-we expect that the angiogenic and regenerative effects of SVF could have assisted in the healing of the friable tissue.…”

Section: Discussionmentioning

confidence: 84%

Stromal vascular fraction injection to treat intractable radiation-induced rectovaginal fistula

et al. 2021

View full text Add to dashboard Cite

Rectovaginal fistula, which can arise after an injury to the vaginal canal or rectum, is a troublesome obstacle for patients’ everyday life. In most cases, it can be covered with a local flap, but previous radiation therapy increases the recurrence rate, making it especially difficult to cure. As the application of stromal vascular fraction (SVF) obtained from enzymatically digested autologous adipose tissue has become increasingly common, several reports have advocated its effectiveness for the treatment of refractory wounds. In light of the angiogenic, regenerative characteristics of SVF, it was incorporated as a treatment option in two cases of rectovaginal fistula discussed here. As described in this report, irradiated rectovaginal fistulas in rectal cancer patients were successfully treated with SVF injection, and we suggest SVF as a feasible treatment option for cases of rectovaginal fistula that would otherwise be very difficult to cure.

show abstract

Section: Discussionmentioning

confidence: 84%

Stromal vascular fraction injection to treat intractable radiation-induced rectovaginal fistula

et al. 2021

View full text Add to dashboard Cite

show abstract

“…To our knowledge, this is the first evidence showing that ASCs may have an enhancing effect on blood vessel size after burn grafting. Vasodilation has been hypothesized to be a potential mechanism of the increase in blood flow due to ASCs , and clearly may be a factor in the current model. ASCs have also been shown to have other effects on wound healing such as acceleration of reepithelialization both in ocular wounds and in cutaneous wounds in diabetic rats .…”

Section: Discussionmentioning

confidence: 99%

Delivery of Allogeneic Adipose Stem Cells in Polyethylene Glycol-Fibrin Hydrogels as an Adjunct to Meshed Autografts After Sharp Debridement of Deep Partial Thickness Burns

Burmeister

Stone

Wrice

et al. 2018

Stem Cells Translational Medicine

View full text Add to dashboard Cite

Harvesting of autografts results in donor site morbidities and is limited in scenarios such as large total body surface area burns. In these instances, coverage is increased by meshing grafts at the expense of delayed biologic closure. Moreover, graft meshing increases the likelihood of contraction and hypertrophic scarring, limits range of motion, and worsens cosmesis. Many tissue engineering technologies have touted the promise of adipose‐derived stem cells (ASCs) for burn wounds. The primary objective of the current study was to determine feasibility and efficacy of in situ ASC delivery via PEGylated fibrin (FPEG) hydrogels as adjuncts to meshed split thickness skin grafts in a porcine model. Deep partial thickness burns were created on the dorsum of anesthetized Yorkshire pigs, and subsequently debrided on post‐burn day 4. After debridement, wounds were treated with: split thickness skin grafts (STSG); meshed STSG (mSTSG); and mSTSG + FPEG with increasing doses of ASCs. We show that FPEG hydrogels can be delivered in situ to prevent the contraction seen after meshing of STSG. Moreover, ASCs delivered in FPEG dose‐dependently increase blood vessel size which significantly correlates with CD31 protein levels. The current study reports a dual‐action adjunct therapy to autografting administered in situ, wherein FPEG acts as both scaffolding to prevent contraction, and as a delivery vehicle for ASCs to accelerate angiogenesis. This strategy may be used to incorporate other biologics for generating tissue engineered products aimed at improving wound healing and minimizing donor sites or scarring. stem cells translational medicine 2018;7:360–372

show abstract

“…The mechanism may be both neovascularisation and vasodilation in addition to endothelial repair. 204 A clinical study of the treatment of radiotherapy-induced injury by lipoaspirate-containing ADSCs showed improved outcomes for 20 grade 3 or 4 patients on the Late Effects Normal Tissue Task force -Subjective, Objective, Management, Analytic (LENT-SOMA) scale measuring severity of radiation effects, with improvement or remission of symptoms in all 20 patients. 205 Further investigation of the effects of adjuvant cancer therapies, both cytotoxic and targeted on ADSC-based tissue regeneration, is required before this method of breast reconstruction can be considered for translation into the clinical setting.…”

Section: Targeted Therapiesmentioning

confidence: 99%

Adipose-Derived Stem Cells in Novel Approaches to Breast Reconstruction: Their Suitability for Tissue Engineering and Oncological Safety

O’Halloran

Courtney

Kerin

et al. 2017

Breast Cancer�(Auckl)

View full text Add to dashboard Cite

Adipose-derived stem cells (ADSCs) are rapidly becoming the gold standard cell source for tissue engineering strategies and hold great potential for novel breast reconstruction strategies. However, their use in patients with breast cancer is controversial and their oncological safety, particularly in relation to local disease recurrence, has been questioned. In vitro, in vivo, and clinical studies using ADSCs report conflicting data on their suitability for adipose tissue regeneration in patients with cancer. This review aims to provide an overview of the potential role for ADSCs in breast reconstruction and to examine the evidence relating to the oncologic safety of their use in patients with breast cancer.

show abstract

Adipose-Derived Stem Cells Improve Survival of Random Pattern Cutaneous Flaps in Radiation Damaged Skin

Abstract: These findings suggest that ADSCs have a potential for enhancing the blood supply of random pattern skin flaps after radiation injury. This mechanism might be both neovascularization and vasodilation along with endothelial repair. Further studies are needed.

Cited by 17 publications

References 23 publications

Stromal vascular fraction injection to treat intractable radiation-induced rectovaginal fistula

Stromal vascular fraction injection to treat intractable radiation-induced rectovaginal fistula

Delivery of Allogeneic Adipose Stem Cells in Polyethylene Glycol-Fibrin Hydrogels as an Adjunct to Meshed Autografts After Sharp Debridement of Deep Partial Thickness Burns

Adipose-Derived Stem Cells in Novel Approaches to Breast Reconstruction: Their Suitability for Tissue Engineering and Oncological Safety

Contact Info

Product

Resources

About