2023
DOI: 10.1167/iovs.64.13.29
|View full text |Cite
|
Sign up to set email alerts
|

Adipose Mesenchymal Stem Cell-Derived Exosomes Promote the Regeneration of Corneal Endothelium Through Ameliorating Senescence

Yunkyoung Ryu,
Jin Sun Hwang,
Kyung Bo Noh
et al.

Abstract: Purpose Human corneal endothelial cells (hCECs) have been considered unable to regenerate in vivo, resulting in corneal decompensation after significant loss of hCECs. adipose-derived mesenchymal stem cell (ASC)-derived exosomes can regenerate tissues and organs. In this study, we investigated whether ASC-derived exosomes could protect and regenerate CECs. Methods We performed cell viability and cell-cycle analyses to evaluate the effect of ASC-derived exosomes on the r… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

1
2
0

Year Published

2024
2024
2025
2025

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 14 publications
(3 citation statements)
references
References 125 publications
1
2
0
Order By: Relevance
“…The relevance of this research work spans beyond the development of novel therapeutic approaches to treat corneal injuries in horses, being also of great interest for the application in humans. In this regard, our results complement previous studies demonstrating the beneficial role of EVs in treating human corneal injuries [64,109,110], providing valuable insights for the advancement of this field.…”
Section: Discussionsupporting
confidence: 85%
“…The relevance of this research work spans beyond the development of novel therapeutic approaches to treat corneal injuries in horses, being also of great interest for the application in humans. In this regard, our results complement previous studies demonstrating the beneficial role of EVs in treating human corneal injuries [64,109,110], providing valuable insights for the advancement of this field.…”
Section: Discussionsupporting
confidence: 85%
“…These EVs also decreased EC barrier permeability at least partly through modulating immune cell activation and releasing anti-inflammatory molecules (prostaglandin E2, keratinocyte growth factor, and IL-10). Additionally, human adipose MSC-derived exosomes internalized by electroporated rat corneal ECs demonstrated the inhibition of EC autophagy and mitochondrial dysfunction, promoting EC recovery and proliferation after cryoinjury, leading to EC regeneration [ 73 ]. Altogether, these study results indicate that SC-derived EVs can significantly improve EC function and recovery after injury in several diseases, pointing to EVs’ potential for enhancing B-CNS-B integrity in ALS.…”
Section: Noncellular Approach To B-cns-b Repairmentioning
confidence: 99%
“…Corneal TE: Exploring an effective treatment that could achieve multi-dimensional repair of the injured cornea, the use of ADSCs was reported as an important component in the healing of corneal epithelium and limbus, the inhibition of corneal stromal fibrosis, angiogenesis, lymphangiogenesis, and also in the repair of corneal nerves, including diabetic corneal epithelial healing [149][150][151][152].…”
Section: Regenerative Features and Utility In Tissue Engineeringmentioning
confidence: 99%