Adipose mesenchymal stem cells–derived exosomes attenuate retina degeneration of streptozotocin-induced diabetes in rabbits

Safwat, A; Sabry, Dina; Ragiae, A; Amer, Eman; Mahmoud, Rania H.; Shamardan, Ramadan Mostafa

doi:10.33393/jcb.2018.2096

Cited by 9 publications

(3 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, mesenchymal stem cells (MSCs) have been extensively studied in various ocular diseases, and MSC-derived exosomes promote retinal ganglion cell survival and preserve their functions [51][52][53][54][55]. In another study, MSC-derived exosomes effectively reduced the expression of inflammatory cytokines and ameliorated diabetic retinopathy progression in the retinas of diabetic rats [44,56]. Moreover, MSCs play an important role in wound modulation in retinal injuries [45,46].…”

Section: Discussionmentioning

confidence: 99%

Intravitreal Administration of Retinal Organoids-Derived Exosomes Alleviates Photoreceptor Degeneration in Royal College of Surgeons Rats by Targeting the Mitogen-Activated Protein Kinase Pathway

Han

Chang

Yang

et al. 2023

IJMS

View full text Add to dashboard Cite

Increasing evidence suggests that exosomes are involved in retinal cell degeneration, including their insufficient release; hence, they have become important indicators of retinopathies. The exosomal microRNA (miRNA), in particular, play important roles in regulating ocular and retinal cell functions, including photoreceptor maturation, maintenance, and visual function. Here, we generated retinal organoids (ROs) from human induced pluripotent stem cells that differentiated in a conditioned medium for 60 days, after which exosomes were extracted from ROs (Exo-ROs). Subsequently, we intravitreally injected the Exo-RO solution into the eyes of the Royal College of Surgeons (RCS) rats. Intravitreal Exo-RO administration reduced photoreceptor apoptosis, prevented outer nuclear layer thinning, and preserved visual function in RCS rats. RNA sequencing and miRNA profiling showed that exosomal miRNAs are mainly involved in the mitogen-activated protein kinase (MAPK) signaling pathway. In addition, the expression of MAPK-related genes and proteins was significantly decreased in the Exo-RO-treated group. These results suggest that Exo-ROs may be a potentially novel strategy for delaying retinal degeneration by targeting the MAPK signaling pathway.

show abstract

Section: Discussionmentioning

confidence: 99%

Intravitreal Administration of Retinal Organoids-Derived Exosomes Alleviates Photoreceptor Degeneration in Royal College of Surgeons Rats by Targeting the Mitogen-Activated Protein Kinase Pathway

Han

Chang

Yang

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…In addition, they can differentiate into PCs or protect them from dropout 112 . Adipose tissue‐sourced MSC molecules, such as neural growth factor, BDNF, and glial cell‐derived neurotrophic factor were demonstrated to enhance neurogenesis and alleviate retinal cell injury, while miRNA‐192 and miRNA‐222 reduce inflammation and benefit retinal vascularization 113,114 . Injecting adipose‐derived stem cells expressing PC markers into murine eyes significantly protected vessels from degeneration in both OIR and DR models.…”

Section: Pericyte‐based Therapeutic Potentialsmentioning

confidence: 99%

Pericyte in retinal vascular diseases: A multifunctional regulator and potential therapeutic target

Zhang,

Yan,

Han

et al. 2024

The FASEB Journal

View full text Add to dashboard Cite

Retinal vascular diseases (RVDs), in particular diabetic retinopathy, retinal vein occlusion, and retinopathy of prematurity, are leading contributors to blindness. The pathogenesis of RVD involves vessel dilatation, leakage, and occlusion; however, the specific underlying mechanisms remain unclear. Recent findings have indicated that pericytes (PCs), as critical members of the vascular mural cells, significantly contribute to the progression of RVDs, including detachment from microvessels, alteration of contractile and secretory properties, and excessive production of the extracellular matrix. Moreover, PCs are believed to have mesenchymal stem properties and, therefore, might contribute to regenerative therapy. Here, we review novel ideas concerning PC characteristics and functions in RVDs and discuss potential therapeutic strategies based on PCs, including the targeting of pathological signals and cell‐based regenerative treatments.

show abstract

“… 64 MSC exosomes reduced the hyperglycemia‐induced retinal inflammation in diabetic retinopathy. 65 Human MSC exosomes have been shown to inhibit the autoimmune response, protect the retinal structure and rescue retinal function in uveitis. 66 Umbilical code‐MSC derived exosomes has been shown to promote RGC survival and glial cell activation in rats with optic neuropathy.…”

Section: Evs In Eye Diseasesmentioning

confidence: 99%

Role of extracellular vesicles in mitochondrial eye diseases

2022

View full text Add to dashboard Cite

Extracellular vesicles (EVs) are small packages that are released by almost all types of cells. While the role of EVs in pathogenesis of certain diseases such as cancer is well established, EVs role in ocular health and disease is still at early stages of investigation. Given the significant role of EVs in pathological development and progression of diseases such as cancer, EVs present a similar opportunity for investigation in ocular pathophysiology. Studies have shown the presence of EVs in fluids from the ocular environment have close links with ocular health and disease. Hence, the cargo carried in EVs from ocular fluids can be used for monitoring disease phenotypes or therapeutic outcomes in eye‐related disorders. Furthermore, in recent times EVs have increasingly gained attention as therapeutics and drug‐delivery vehicles for treatment of eye diseases. There is a close relationship between EVs and mitochondria functioning with mitochondria dysfunction leading to a significant number of ophthalmic disorders. This review discusses the current knowledge of EVs in visual systems with a special focus on eye diseases resulting from dysfunctional mitochondria.

show abstract

Adipose mesenchymal stem cells–derived exosomes attenuate retina degeneration of streptozotocin-induced diabetes in rabbits

Abstract: non disponibile

Cited by 9 publications

References 42 publications

Intravitreal Administration of Retinal Organoids-Derived Exosomes Alleviates Photoreceptor Degeneration in Royal College of Surgeons Rats by Targeting the Mitogen-Activated Protein Kinase Pathway

Intravitreal Administration of Retinal Organoids-Derived Exosomes Alleviates Photoreceptor Degeneration in Royal College of Surgeons Rats by Targeting the Mitogen-Activated Protein Kinase Pathway

Pericyte in retinal vascular diseases: A multifunctional regulator and potential therapeutic target

Role of extracellular vesicles in mitochondrial eye diseases

Contact Info

Product

Resources

About