Adipose Tissue: A Regulator for Obesity and Its Complications

Rahiman, Shaik; Shrivastava, Divya

doi:10.9734/ijbcrr/2016/18221

Cited by 2 publications

(3 citation statements)

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“…To maintain normal metabolic processes, mesenteric fat tissue produces anti-inflammatory factors such as adiponectin. Dysregulation of the endocrine and immune functions of mesenteric fat tissue ultimately leads to insulin resistance, liver steatosis, and various cardiovascular and autoimmune diseases ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

The Mesentery’s Pivotal Role in the Brain-Gut-Liver Axis

Zildzic,

Salihefendic,

Masic

2024

Med Arch

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Background: Prior to 2012, the mesentery was perceived as a fragmented structure, lacking distinct functional and anatomical characteristics, and was merely considered part of other digestive organs. Dr. J. Calvin Coffey's in 2012 in his study redefined the mesentery as a distinct organ with a clearly defined anatomical and histological structure, although its specific function remains under investigation. The continuous structure and unique tissue properties of the mesentery classify it as the 78th independent organ in the human body. Insights into mesenteric adipose tissue have enhanced our understanding of normal metabolic processes and disease etiology, impacting health significantly. Experimental and clinical research highlights the vital roles of visceral adipose tissue, influencing neighboring organ function. The interaction within the brain-gut-liver axis is illuminated by the newfound functions of mesenteric adipose tissue, emphasizing its independent organ status. Objective: This study aims to evaluate the latest findings on the structure and function of the mesentery, focusing on visceral-mesenteric adipose tissue, and assess its role as a new organ in the brain-gut-liver axis. Methods: A comprehensive analysis of clinical and experimental studies on the mesentery's structure and function was conducted, focusing on recent discoveries regarding mesenteric adipose tissue and its role in the brain-gut-liver axis. Results and Discussion: Recent research has revealed the mesentery's unique functions, particularly in mesenteric adipose tissue. Mesenteric adipose tissue plays a crucial role in metabolic functions and influences disease onset. It acts as a vital link in the brain-gut-liver axis, directly influencing hepatic metabolism and disorders such as metabolic syndrome. Conclusion: Scientific evidence confirms the mesentery's anatomical and functional specificities, solidifying its status as the 78th independent organ in the human body. It serves as a crucial link in the brain-mesentery-small intestine-liver axis, impacting health and disease. Ongoing research holds promise for advancing our understanding of pathophysiological mechanisms and treatment approaches for metabolic syndrome and other chronic diseases.

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Section: Introductionmentioning

confidence: 99%

The Mesentery’s Pivotal Role in the Brain-Gut-Liver Axis

Zildzic,

Salihefendic,

Masic

2024

Med Arch

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“…Oleu has a wide range of anti‐inflammatory, anti‐microbic, antioxidant, and immunomodulatory activities [11] . A number of studies have shown that the consumption of Oleu decreases cancer incidence, especially in the stomach, breast, and colorectal cancer, due to its antioxidant property [12] . However, recent studies have shown that the effects of Oleu on cancer go beyond that, where it acts as a both anti‐proliferative and apoptotic promoter in a number of cancer cells [13] .…”

Section: Introductionmentioning

confidence: 99%

“…[11] A number of studies have shown that the consumption of Oleu decreases cancer incidence, especially in the stomach, breast, and colorectal cancer, due to its antioxidant property. [12] However, recent studies have shown that the effects of Oleu on cancer go beyond that, where it acts as a both anti-proliferative and apoptotic promoter in a number of cancer cells. [13] The Oleu effects on cancer cells are influenced by its concentration, exposure time, and the type of cancer cell.…”

Section: Introductionmentioning

confidence: 99%

Development of Pegylated Nano‐Phytosome Formulation with Oleuropein and Rutin to Compare Anti‐Colonic Cancer Activity with Olea Europaea Leaves Extract

Mahmood,

Al‐Samydai,

Sulaibi

et al. 2023

Chemistry & Biodiversity

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Olive leaf extract is a valuable source of phenolic compounds; primarily, oleuropein (major component) and rutin. This natural olive leaf extract has potential use as a therapeutic agent for cancer treatment. However, its clinical application is hindered by poor pharmacokinetics and low stability. To overcome these limitations, this study aimed to enhance the anticancer activity and stability of oleuropein and rutin by loading them into PEGylated Nano‐phytosomes. The developed PEGylated Nano‐phytosomes exhibited favorable characteristics in terms of size, charge, and stability. Notably, the anticolonic cancer activity of the Pegylated Nano‐phytosomes loaded with oleuropein (IC50=0.14 μM) and rutin (IC50=0.44 μM) surpassed that of pure oleuropein and rutin alone. This outcome highlights the advantageous impact of Nano‐phytosomes to augment the anticancer potential of oleuropein and rutin. These results present a promising pathway for the future development of oleuropein and rutin Nano‐phytosomes as effective options for passive tumor‐targeted therapy, given their improved stability and efficacy.

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Adipose Tissue: A Regulator for Obesity and Its Complications

Cited by 2 publications

References 0 publications

The Mesentery’s Pivotal Role in the Brain-Gut-Liver Axis

The Mesentery’s Pivotal Role in the Brain-Gut-Liver Axis

Development of Pegylated Nano‐Phytosome Formulation with Oleuropein and Rutin to Compare Anti‐Colonic Cancer Activity with Olea Europaea Leaves Extract

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