Adipose tissue and insulin resistance in obese

Ahmed, Bulbul; Sultana, Rifat; Greene, Michael W.

doi:10.1016/j.biopha.2021.111315

Cited by 458 publications

(293 citation statements)

References 221 publications

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“…As concerns skeletal muscle, protein expression can be influenced by the same factors [ 49 ] and by differences in the levels of adipose tissue-derived circulating hormones, chemokines, cytokines, and inflammatory regulators [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Dysfunctional organelles promote the release of FFAs and their intermediates (e.g., diacylglycerol, linoleic, phosphatidic and lysophosphatidic acids and ceramides), proinflammatory molecules and ROS. The increase of these molecules in the bloodstream [ 17 , 18 ] can develop a low-grade systemic inflammation that determines the onset of insulin resistance [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Skeletal Muscle Proteomic Profile Revealed Gender-Related Metabolic Responses in a Diet-Induced Obesity Animal Model

Moriggi

Belloli

Barbacini

et al. 2021

IJMS

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Obesity is a chronic, complex pathology associated with a risk of developing secondary pathologies, including cardiovascular diseases, cancer, type 2 diabetes (T2DM) and musculoskeletal disorders. Since skeletal muscle accounts for more than 70% of total glucose disposal, metabolic alterations are strictly associated with the onset of insulin resistance and T2DM. The present study relies on the proteomic analysis of gastrocnemius muscle from 15 male and 15 female C56BL/J mice fed for 14 weeks with standard, 45% or 60% high-fat diets (HFD) adopting a label-free LC–MS/MS approach followed by bioinformatic pathway analysis. Results indicate changes in males due to HFD, with increased muscular stiffness (Col1a1, Col1a2, Actb), fiber-type switch from slow/oxidative to fast/glycolytic (decreased Myh7, Myl2, Myl3 and increased Myh2, Mylpf, Mybpc2, Myl1), increased oxidative stress and mitochondrial dysfunction (decreased respiratory chain complex I and V and increased complex III subunits). At variance, females show few alterations and activation of compensatory mechanisms to counteract the increase of fatty acids. Bioinformatics analysis allows identifying upstream molecules involved in regulating pathways identified at variance in our analysis (Ppargc1a, Pparg, Cpt1b, Clpp, Tp53, Kdm5a, Hif1a). These findings underline the presence of a gender-specific response to be considered when approaching obesity and related comorbidities.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Skeletal Muscle Proteomic Profile Revealed Gender-Related Metabolic Responses in a Diet-Induced Obesity Animal Model

Moriggi

Belloli

Barbacini

et al. 2021

IJMS

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show abstract

“…Accumulating evidence suggests that insulin resistance is not only induced by fat accumulation in adipose tissues but also by pro-inflammation caused by ectopic fat toxic lipids, such as ceramides, which alter the insulin signaling pathway, generates ROS-induced ER stress, and induces inflammation during the development of T2D [ 151 ]. It has also been reported that CD36-dependent inflammation and the apoptosis of adipocytes in response to diet-induced obesity reduces insulin sensitivity [ 152 ]. These changes are related to the activation of stress signaling pathways, such as the JNK, NF-κB, and ER stress cascades [ 153 , 154 ].…”

Section: Role Of Cd36 In Peripheral Insulin Resistance and Metainflammationmentioning

confidence: 99%

CD36 Signal Transduction in Metabolic Diseases: Novel Insights and Therapeutic Targeting

Karunakaran

Elumalai

Moon

et al. 2021

Cells

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The cluster of differentiation 36 (CD36) is a scavenger receptor present on various types of cells and has multiple biological functions that may be important in inflammation and in the pathogenesis of metabolic diseases, including diabetes. Here, we consider recent insights into how the CD36 response becomes deregulated under metabolic conditions, as well as the therapeutic benefits of CD36 inhibition, which may provide clues for developing strategies aimed at the treatment or prevention of diabetes associated with metabolic diseases. To facilitate this process further, it is important to pinpoint regulatory mechanisms that are relevant under physiological and pathological conditions. In particular, understanding the mechanisms involved in dictating specific CD36 downstream cellular outcomes will aid in the discovery of potent compounds that target specific CD36 downstream signaling cascades.

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“…25,27 Enlarging and increasing adipocyte tissues in obesity are mediated by immuneassociated cells that increase proinflammation cytokines. 28 High CRP levels are related to the increased expression and release of IL-6 by adipose tissue. CRP is synthesized not only primarily in liver hepatocytes but also in smooth muscle cells, macrophages, endothelial cells, lymphocytes, and adipocytes.…”

Section: Discussionmentioning

confidence: 99%

The Correlation Between Adiponectin Levels With C-Reactive Protein in Adult Obese Non-Diabetic Among Staffs of DR. M. Djamil Hospital Padang

et al. 2021

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The adiponectin and C-reactive protein (CRP) are markers of chronic low-grade inflammation related to obesity. This study aims to determine a correlation between adiponectin level and CRP level in adult obese individuals. This study was analyzed with a cross-sectional design of 55 subjects at Dr. M Jamil Central Hospital Padang from January to September 2019. The subjects included were type 1 obese (25≤BMI≤29.9 kg/m2) and type 2 obese (BMI 30.0 kg/m2). Enzyme-linked immunoassay (ELISA) was used to measure adiponectin and High Sensitivity C-Reactive Protein (Hs-CRP) levels. Univariate statistical analysis is processed and presented in distribution, frequency, mean (standard deviation), median (minimum-maximum value). Bivariate data were analyzed using the Pearson correlation test, significant if p<0.05. The study consists of 16 males and 39 females. The mean age was 35 years old (the range 23 to 57 years old), the mean BMI was 30.8 (4.5) kg/m2. This study consists of 28 subjects, type 1 obese and 27 types II obese. The mean adiponectin level in type 2 obese is lower than in type 2 obese groups. The mean CRP levels are high in all populations. Pearson ln-adiponectin and CRP correlation test in the entire population: r =-0.105 (p=0.444).

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Adipose tissue and insulin resistance in obese

Cited by 458 publications

References 221 publications

Skeletal Muscle Proteomic Profile Revealed Gender-Related Metabolic Responses in a Diet-Induced Obesity Animal Model

Skeletal Muscle Proteomic Profile Revealed Gender-Related Metabolic Responses in a Diet-Induced Obesity Animal Model

CD36 Signal Transduction in Metabolic Diseases: Novel Insights and Therapeutic Targeting

The Correlation Between Adiponectin Levels With C-Reactive Protein in Adult Obese Non-Diabetic Among Staffs of DR. M. Djamil Hospital Padang

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