Adipose tissue proteomes of intrauterine growth-restricted piglets artificially reared on a high-protein neonatal formula

Sarr, Ousseynou; Louveau, Isabelle; Huërou‐Luron, Isabelle Le; Gondret, Florence

doi:10.1016/j.jnutbio.2011.09.002

Cited by 14 publications

(10 citation statements)

References 41 publications

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“…As reported, PPIA is an important pathogenic factor in various human chronic diseases such as HIV infection, cardiovascular diseases, and cancers . Recently, it was found that PPIA expression was elevated in a high‐protein diet and type 2 diabetes . In this study, our findings are the first suggesting PPIA is a novel adipogenic factor important in obesity.…”

Section: Discussionsupporting

confidence: 71%

“…Very recently, it was reported that PPIA was elevated in the serum of patients with type 2 diabetes , and PPIA secretion increased during 3T3L1 adipocyte differentiation . Moreover, in intrauterine growth‐restricted piglets fed with high‐protein neonatal formula, both PPIA expression in adipose tissue and the size of adipocytes increased . These data suggested that PPIA might be associated with the occurrence of adiposity and type 2 diabetes.…”

Section: Introductionmentioning

confidence: 89%

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PPIA is a novel adipogenic factor implicated in obesity

Zhang

et al. 2015

Obesity

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Objective: To assess the role of peptidyl-prolyl cis/trans isomerase a (PPIA) in adipogenesis and obesity. Methods: Fat mass and adipocyte sizes of PPIA2/2 and wild-type mice were compared. The role of PPIA in adipocyte differentiation of 3T3L1 and MEFs cells was analyzed by gene silencing and overexpression. The roles of PPIA in obesity were observed on a high-fat diet obesity model and a gestational diabetes obesity model. Results: PPIA2/2 mice had significantly less fat than PPIA1/1 mice. The adipocyte size of PPIA2/2 mice was significantly smaller than wild type. Silencing PPIA in 3T3L1 cells significantly impaired its adipocyte differentiation ability. Similarly, MEFs from PPIA2/2 mice differentiated less than wild type, while their differentiation ability was restored by PPIA overexpression. PPIA-silenced 3T3L1 cells had significantly lower expression of PPARG, C/EBPA, and C/EBPB at late stage of adipocyte differentiation, which was the same in PPIA2/2 MEFs. When fed a high-fat diet, PPIA2/2 mice gained significantly less weight than wild type, accompanied by reduced PPARG, C/EBPA, and C/EBPB expression. PPIA expression was significantly higher in adipose tissue of gestational diabetes rat offspring, which had higher inguinal fat/body weight ratios than normal rat offspring. Conclusions: PPIA was a novel adipogenic factor important in obesity.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 89%

PPIA is a novel adipogenic factor implicated in obesity

Zhang

et al. 2015

Obesity

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“…Proteomics technologies facilitate the analysis of thousands of proteins, providing powerful tools for assessing skeletal development and meat quality in pigs . Proteomics identified 23 proteins in the skeletal muscle that were affected by HS.…”

Section: Discussionmentioning

confidence: 99%

Proteomic changes of the porcine skeletal muscle in response to chronic heat stress

et al. 2018

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The results indicate that HS-induced changes in the expression of myofibrillar proteins, glucose and energy metabolism-related proteins, heat shock protein and antioxidant enzymes might, at least partly, contribute to increase in meat tenderness. These findings will provide the foundation for developing future mitigating solutions and preventative therapies to reduce the detrimental effects of chronic HS on muscle function, metabolism and meat quality. © 2017 Society of Chemical Industry.

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“…Carcasses of pigs born from low-protein fed gilts and then cross-fostered to sows fed a standard diet contained less lean but more fat than control pigs at 6 months of age, while excess dietary protein during gestation seems to have little effect on the fetal programming of postnatal adipose tissue phenotype of the progeny (Rehfeldt et al, 2012b). An exposure of piglets to a high protein formula during the suckling period induces a transitory reduction in adipose tissue development in pigs born with a low birth weight, with greater proportion of adipocytes with small diameters and various changes in protein abundance in WAT at weaning compared with pigs receiving formula with an adequate protein content (Sarr et al, 2012). This results in modifications in subsequent fat growth trajectories at peripubertal age with enlarged adipocytes and altered rates of glucose incorporation into lipids, despite a similar body composition (Sarr et al, 2011).…”

Section: Prenatal and Postnatal Growth Of Adipose Tissuesmentioning

confidence: 99%

Invited review: Pre- and postnatal adipose tissue development in farm animals: from stem cells to adipocyte physiology

Louveau

Perruchot

Bonnet

et al. 2016

Animal

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Both white and brown adipose tissues are recognized to be differently involved in energy metabolism and are also able to secrete a variety of factors called adipokines that are involved in a wide range of physiological and metabolic functions. Brown adipose tissue is predominant around birth, except in pigs. Irrespective of species, white adipose tissue has a large capacity to expand postnatally and is able to adapt to a variety of factors. The aim of this review is to update the cellular and molecular mechanisms associated with pre-and postnatal adipose tissue development with a special focus on pigs and ruminants. In contrast to other tissues, the embryonic origin of adipose cells remains the subject of debate. Adipose cells arise from the recruitment of specific multipotent stem cells/progenitors named adipose tissue-derived stromal cells. Recent studies have highlighted the existence of a variety of those cells being able to differentiate into white, brown or brown-like/beige adipocytes. After commitment to the adipocyte lineage, progenitors undergo large changes in the expression of many genes involved in cell cycle arrest, lipid accumulation and secretory functions. Early nutrition can affect these processes during fetal and perinatal periods and can also influence or pre-determinate later growth of adipose tissue. How these changes may be related to adipose tissue functional maturity around birth and can influence newborn survival is discussed. Altogether, a better knowledge of fetal and postnatal adipose tissue development is important for various aspects of animal production, including neonatal survival, postnatal growth efficiency and health.

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Adipose tissue proteomes of intrauterine growth-restricted piglets artificially reared on a high-protein neonatal formula

Cited by 14 publications

References 41 publications

PPIA is a novel adipogenic factor implicated in obesity

PPIA is a novel adipogenic factor implicated in obesity

Proteomic changes of the porcine skeletal muscle in response to chronic heat stress

Invited review: Pre- and postnatal adipose tissue development in farm animals: from stem cells to adipocyte physiology

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