Adiposity measures and vitamin D concentrations in Northeast Germany and Denmark

Hannemann, Anke; Thuesen, Betina Heinsbæk; Friedrich, Nele; Völzke, Henry; Steveling, Antje; Ittermann, Till; Hegenscheid, Katrin; Nauck, Matthias; Linneberg, Allan; Wallaschofski, Henri

doi:10.1186/s12986-015-0019-0

Cited by 30 publications

(27 citation statements)

References 39 publications

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“…Next to common adiposity measures, we also discovered that VFA was inversely associated with serum 25(OH) D 3 concentrations in Chinese men and pre-menopausal women, which was similar to the recent study in Northeast Germany and Denmark [ 38 ] and China [ 16 ]. Differed from Hao’s study among Chinese population, our study population included men and women, and included the participants who were diabetes.…”

Section: Discussionsupporting

confidence: 86%

Higher visceral fat area increases the risk of vitamin D insufficiency and deficiency in Chinese adults

Zhang

Zhu

et al. 2015

Nutr Metab (Lond)

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BackgroundVisceral fat area (VFA), a novel sex-specific index for visceral fat obesity (VFO) might play a major role in the development of vitamin D deficiency. However, the association between VFA and vitamin D insufficiency and deficiency in Chinese population is less clear. The aim of this study was to explore the population-level association between VFA and vitamin D insufficiency and deficiency among Chinese men and women.MethodsThis cross-sectional study involved 1105 adults aged 20–70 years living in Tianjin who were randomly selected and medically examined. All subjects underwent the bioelectrical impedance analysis (BIA) method to estimate the VFA. Serum 25-hydroxyvitamin D3 (25(OH) D3) level was assayed by the high-performance liquid chromatography (HPLC) method and defined insufficiency and deficiency following recommended cutoffs. The association between VFA and vitamin D insufficiency and deficiency was estimated using binary regression analysis.ResultsThe total prevalence of vitamin D insufficiency (25(OH) D3: 20–29 μg/L) and deficiency (25(OH) D3 < 20 μg/L) were 26.60 % and 24.89 %, respectively. Significant negative association was observed for VFA with serum 25(OH) D3 levels in men and pre-menopausal women (P < 0.05), not in post-menopausal women (P > 0.05). Moreover, increased VFA was observed to be associated with higher vitamin D insufficiency or deficiency risk with a positive dose–response trend (P for trend < 0.001). As compared to individuals with the lowest VFA, those who had the highest VFA were at 4.9-fold risk of vitamin D insufficiency and deficiency [95 % confidence interval (95 % CI): 1.792–13.365] in men and 1.8-fold risk of vitamin D insufficiency and deficiency (95 % CI: 1.051–3.210) in pre-menopausal women, but not in post-menopausal women [odds ratio (OR) (95 % CI): 2.326(0.903–5.991)].ConclusionsThese results suggest that higher VFA increases the risk of vitamin D insufficiency and deficiency in men and pre-menopausal women, but not in post-menopausal women. VFA is a better and convenience surrogate marker for visceral adipose measurement and could be used in identifying the risk of vitamin D insufficiency and deficiency in routine health examination.

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Section: Discussionsupporting

confidence: 86%

Higher visceral fat area increases the risk of vitamin D insufficiency and deficiency in Chinese adults

Zhang

Zhu

et al. 2015

Nutr Metab (Lond)

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“…In another study, a significant negative correlation was found between body fat and vitamin D serum levels [ 45 ]. In this sense, a cross-sectional study showed that weight, body fat mass, and BMI were negatively correlated to 25(OH)D levels [ 46 ], as well as WC and other obesity markers [ 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults

Elizondo‐Montemayor

Castillo

López

et al. 2017

Mediators of Inflammation

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Vitamin D deficiency is present even in sunny regions. Ageing decreases pre-vitamin D production in the skin and is associated with altered cytokine profile. We performed a multivariate analysis considering lifestyle factors, anthropometric, and inflammatory markers according to seasonal variation in Mexican healthy older adults. The same cohort was followed during 12 months. Vitamin D deficiency/insufficiency was found in 91.3% of the subjects despite living in appropriate latitude (25°40′0″N). 25(OH)D levels remained below <30 ng/mL through all seasons. Vitamin D deficiency did not correlate to sun exposure or dietary intake. Gender was the strongest associated factor, explaining a variance of 20%. Waist circumference (WC) greater than 88 cm was a risk factor for vitamin D deficiency. Age (>74 years) combined with WC (>88 cm) and BMI (>32.7) showed a high probability (90%) of vitamin D deficiency. Remarkably, an increase in one centimeter in WC decreased 25(OH)D by 0.176 ng/mL, while an increase in one point BMI decreased 25(OH)D by 0.534 ng/mL. A cutoff point of 74 years of age determined probability of vitamin D hipovitaminosis. Vitamin D deficiency was correlated with TNF-α serum levels, possibly increasing the susceptibility of older adults to a proinflammatory state and its related diseases.

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“…VAT was the distance in centimeters between the posterior edge of the abdominal muscles and the front of the lumbar spine. 27,28 All ultrasound measures were performed after a quiet expiration applying minimal pressure without the displacement of the intra-abdominal contents as described by Stolk et al 17 with an Aquila Pie Medical, Esaote Europe, Maastricht, The Netherlands. These ultrasound measures have been validated against CT and MRI elsewhere.…”

Section: Exposure Measurementsmentioning

confidence: 99%

Abdominal Adiposity Distribution Quantified by Ultrasound Imaging and Incident Hypertension in a General Population

et al. 2016

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Abstract-Abdominal obesity is a major risk factor for hypertension. However, different distributions of abdominal adipose tissue may affect hypertension risk differently. The main purpose of this study was to explore the association of subcutaneous abdominal adipose tissue (SAT) and visceral adipose tissue (VAT) with incident hypertension in a population-based setting. We hypothesized that VAT, rather than SAT, would be associated with incident hypertension. VAT and SAT were determined by ultrasound imagining in 3363 randomly selected Danes (mean age 49 years, 56% women, mean body mass index 25.8 kg/m 2 ). We constructed multiple logistic regression models to compute standardized odds ratios with 95% confidence intervals per SD increase in SAT and VAT. Of the 2119 normotensive participants at baseline, 1432, with mean SAT of 2.8 cm and mean VAT of 5.7 cm, returned 5 years later for a follow-up examination and among them 203 had developed hypertension. In models including both VAT and SAT, the Framingham Hypertension Risk Score variables (age, sex, smoking status, family history of hypertension, and baseline blood pressure) and glycated hemoglobin, odds ratio (95% confidence interval) for incident hypertension for 1 SD increase in VAT and SAT was 1.27 (1.08-1.50, P=0.004) and 0.97 (0.81-1.15, P=0.70), respectively. Adjusting for body mass index instead of SAT attenuated the association between VAT and incident hypertension, but it was still significant (odds ratio, 1.22 [1.01-1.48, P=0.041] for each SD increase in VAT). In conclusion, ultrasound-determined VAT, but not SAT, was associated with incident hypertension in a random sample of Danish adults.

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Adiposity measures and vitamin D concentrations in Northeast Germany and Denmark

Cited by 30 publications

References 39 publications

Higher visceral fat area increases the risk of vitamin D insufficiency and deficiency in Chinese adults

Higher visceral fat area increases the risk of vitamin D insufficiency and deficiency in Chinese adults

Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults

Abdominal Adiposity Distribution Quantified by Ultrasound Imaging and Incident Hypertension in a General Population

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